eF-site ID 1d1y-B PDB Code 1d1y Chain B click to enlarge Title BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 1,3-PBITU (H4B FREE) Classification OXIDOREDUCTASE Compound BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN Source Bos taurus (Bovine) (NOS3_BOVIN) Sequence B:  KFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLP RKLQTRPSPGPPPAEQLLSQARDFINQYYSSIKRSGSQAH EERLQEVEAEVASTGTYHLRESELVFGAKQAWRNAPRCVG RIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRS AITVFPQRAPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPA NVEITELCIQHGWTPGNGRFDVLPLLLQAPDEAPELFVLP PELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGL EFSAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLD TRTTSSLWKDKAAVEINLAVLHSFQLAKVTIVDHHAATVS FMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVN YILSPAFRYQPDPW Description Functional site 1) chain B residue 249 type sequence Q description BINDING SITE FOR RESIDUE ACT B 851 source : AC3 2) chain B residue 252 type sequence R description BINDING SITE FOR RESIDUE ACT B 851 source : AC3 3) chain B residue 368 type sequence N description BINDING SITE FOR RESIDUE ACT B 851 source : AC3 4) chain B residue 374 type sequence R description BINDING SITE FOR RESIDUE ACT B 851 source : AC3 5) chain B residue 188 type sequence G description BINDING SITE FOR RESIDUE ACT B 861 source : AC4 6) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE ACT B 861 source : AC4 7) chain B residue 420 type sequence V description BINDING SITE FOR RESIDUE ACT B 861 source : AC4 8) chain B residue 428 type sequence S description BINDING SITE FOR RESIDUE ACT B 861 source : AC4 9) chain B residue 96 type sequence C description BINDING SITE FOR RESIDUE ZN B 900 source : AC5 10) chain B residue 101 type sequence C description BINDING SITE FOR RESIDUE ZN B 900 source : AC5 11) chain B residue 180 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 12) chain B residue 185 type sequence R description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 13) chain B residue 186 type sequence C description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 14) chain B residue 228 type sequence S description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 15) chain B residue 355 type sequence F description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 16) chain B residue 356 type sequence S description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 17) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 18) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 19) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 20) chain B residue 477 type sequence Y description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 21) chain B residue 76 type sequence W description BINDING SITE FOR RESIDUE EDO A 870 source : AC9 22) chain B residue 249 type sequence Q description BINDING SITE FOR RESIDUE 3BT B 821 source : BC2 23) chain B residue 336 type sequence P description BINDING SITE FOR RESIDUE 3BT B 821 source : BC2 24) chain B residue 338 type sequence V description BINDING SITE FOR RESIDUE 3BT B 821 source : BC2 25) chain B residue 340 type sequence N description BINDING SITE FOR RESIDUE 3BT B 821 source : BC2 26) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE 3BT B 821 source : BC2 27) chain B residue 359 type sequence Y description BINDING SITE FOR RESIDUE 3BT B 821 source : BC2 28) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE 3BT B 821 source : BC2 29) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE EDO B 871 source : BC3 30) chain B residue 373 type sequence H description BINDING SITE FOR RESIDUE EDO B 871 source : BC3 31) chain B residue 70 type sequence F description BINDING SITE FOR RESIDUE CAD B 951 source : BC4 32) chain B residue 83 type sequence Y description BINDING SITE FOR RESIDUE CAD B 951 source : BC4 33) chain B residue 324 type sequence W description BINDING SITE FOR RESIDUE CAD B 951 source : BC4 34) chain B residue 384 type sequence C description BINDING SITE FOR RESIDUE CAD B 951 source : BC4 35) chain B residue 462 type sequence F description BINDING SITE FOR RESIDUE GOL A 890 source : BC5 36) chain B residue 104 type sequence S description BINDING SITE FOR RESIDUE GOL A 881 source : BC6 37) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE GOL A 881 source : BC6 38) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE GOL B 891 source : BC7 39) chain B residue 448 type sequence A description BINDING SITE FOR RESIDUE GOL B 891 source : BC7 40) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE GOL B 891 source : BC7 41) chain B residue 186 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI3 42) chain B residue 104 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 43) chain B residue 249 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 44) chain B residue 358 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 45) chain B residue 359 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 46) chain B residue 363 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 47) chain B residue 368 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 48) chain B residue 448 type BINDING sequence A description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 49) chain B residue 449 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 50) chain B residue 462 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 51) chain B residue 477 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 52) chain B residue 116 type MOD_RES sequence S description Phosphoserine; by CDK5 => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI4 53) chain B residue 96 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 54) chain B residue 101 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1

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