eF-site ID 1d1y-AB PDB Code 1d1y Chain A, B click to enlarge Title BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 1,3-PBITU (H4B FREE) Classification OXIDOREDUCTASE Compound BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN Source Bos taurus (Bovine) (NOS3_BOVIN) Sequence A:  GPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLV LPRKLQTRPSPGPPPAEQLLSQARDFINQYYSSIKRSGSQ AHEERLQEVEAEVASTGTYHLRESELVFGAKQAWRNAPRC VGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNL RSAITVFPQRAPGRGDFRIWNSQLVRYAGYRQQDGSVRGD PANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEAPELFV LPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIG GLEFSAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMD LDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIVDHHAAT VSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEM VNYILSPAFRYQPDPW B:  KFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLP RKLQTRPSPGPPPAEQLLSQARDFINQYYSSIKRSGSQAH EERLQEVEAEVASTGTYHLRESELVFGAKQAWRNAPRCVG RIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRS AITVFPQRAPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPA NVEITELCIQHGWTPGNGRFDVLPLLLQAPDEAPELFVLP PELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGL EFSAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLD TRTTSSLWKDKAAVEINLAVLHSFQLAKVTIVDHHAATVS FMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVN YILSPAFRYQPDPW Description Functional site 1) chain A residue 249 type sequence Q description BINDING SITE FOR RESIDUE ACT A 850 source : AC1 2) chain A residue 252 type sequence R description BINDING SITE FOR RESIDUE ACT A 850 source : AC1 3) chain A residue 368 type sequence N description BINDING SITE FOR RESIDUE ACT A 850 source : AC1 4) chain A residue 374 type sequence R description BINDING SITE FOR RESIDUE ACT A 850 source : AC1 5) chain A residue 188 type sequence G description BINDING SITE FOR RESIDUE ACT A 860 source : AC2 6) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE ACT A 860 source : AC2 7) chain A residue 420 type sequence V description BINDING SITE FOR RESIDUE ACT A 860 source : AC2 8) chain A residue 428 type sequence S description BINDING SITE FOR RESIDUE ACT A 860 source : AC2 9) chain B residue 249 type sequence Q description BINDING SITE FOR RESIDUE ACT B 851 source : AC3 10) chain B residue 252 type sequence R description BINDING SITE FOR RESIDUE ACT B 851 source : AC3 11) chain B residue 368 type sequence N description BINDING SITE FOR RESIDUE ACT B 851 source : AC3 12) chain B residue 374 type sequence R description BINDING SITE FOR RESIDUE ACT B 851 source : AC3 13) chain B residue 188 type sequence G description BINDING SITE FOR RESIDUE ACT B 861 source : AC4 14) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE ACT B 861 source : AC4 15) chain B residue 420 type sequence V description BINDING SITE FOR RESIDUE ACT B 861 source : AC4 16) chain B residue 428 type sequence S description BINDING SITE FOR RESIDUE ACT B 861 source : AC4 17) chain A residue 96 type sequence C description BINDING SITE FOR RESIDUE ZN B 900 source : AC5 18) chain A residue 101 type sequence C description BINDING SITE FOR RESIDUE ZN B 900 source : AC5 19) chain B residue 96 type sequence C description BINDING SITE FOR RESIDUE ZN B 900 source : AC5 20) chain B residue 101 type sequence C description BINDING SITE FOR RESIDUE ZN B 900 source : AC5 21) chain A residue 180 type sequence W description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 22) chain A residue 185 type sequence R description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 23) chain A residue 186 type sequence C description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 24) chain A residue 228 type sequence S description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 25) chain A residue 341 type sequence M description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 26) chain A residue 355 type sequence F description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 27) chain A residue 356 type sequence S description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 28) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 29) chain A residue 363 type sequence E description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 30) chain A residue 449 type sequence W description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 31) chain A residue 477 type sequence Y description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 32) chain B residue 180 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 33) chain B residue 185 type sequence R description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 34) chain B residue 186 type sequence C description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 35) chain B residue 228 type sequence S description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 36) chain B residue 355 type sequence F description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 37) chain B residue 356 type sequence S description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 38) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 39) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 40) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 41) chain B residue 477 type sequence Y description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 42) chain A residue 248 type sequence S description BINDING SITE FOR RESIDUE 3BT A 820 source : AC8 43) chain A residue 249 type sequence Q description BINDING SITE FOR RESIDUE 3BT A 820 source : AC8 44) chain A residue 336 type sequence P description BINDING SITE FOR RESIDUE 3BT A 820 source : AC8 45) chain A residue 338 type sequence V description BINDING SITE FOR RESIDUE 3BT A 820 source : AC8 46) chain A residue 355 type sequence F description BINDING SITE FOR RESIDUE 3BT A 820 source : AC8 47) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE 3BT A 820 source : AC8 48) chain A residue 359 type sequence Y description BINDING SITE FOR RESIDUE 3BT A 820 source : AC8 49) chain A residue 363 type sequence E description BINDING SITE FOR RESIDUE 3BT A 820 source : AC8 50) chain A residue 367 type sequence R description BINDING SITE FOR RESIDUE EDO A 870 source : AC9 51) chain A residue 373 type sequence H description BINDING SITE FOR RESIDUE EDO A 870 source : AC9 52) chain B residue 76 type sequence W description BINDING SITE FOR RESIDUE EDO A 870 source : AC9 53) chain A residue 324 type sequence W description BINDING SITE FOR RESIDUE CAD A 950 source : BC1 54) chain A residue 384 type sequence C description BINDING SITE FOR RESIDUE CAD A 950 source : BC1 55) chain A residue 438 type sequence K description BINDING SITE FOR RESIDUE CAD A 950 source : BC1 56) chain A residue 440 type sequence R description BINDING SITE FOR RESIDUE CAD A 950 source : BC1 57) chain A residue 441 type sequence G description BINDING SITE FOR RESIDUE CAD A 950 source : BC1 58) chain B residue 249 type sequence Q description BINDING SITE FOR RESIDUE 3BT B 821 source : BC2 59) chain B residue 336 type sequence P description BINDING SITE FOR RESIDUE 3BT B 821 source : BC2 60) chain B residue 338 type sequence V description BINDING SITE FOR RESIDUE 3BT B 821 source : BC2 61) chain B residue 340 type sequence N description BINDING SITE FOR RESIDUE 3BT B 821 source : BC2 62) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE 3BT B 821 source : BC2 63) chain B residue 359 type sequence Y description BINDING SITE FOR RESIDUE 3BT B 821 source : BC2 64) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE 3BT B 821 source : BC2 65) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE EDO B 871 source : BC3 66) chain B residue 373 type sequence H description BINDING SITE FOR RESIDUE EDO B 871 source : BC3 67) chain B residue 70 type sequence F description BINDING SITE FOR RESIDUE CAD B 951 source : BC4 68) chain B residue 83 type sequence Y description BINDING SITE FOR RESIDUE CAD B 951 source : BC4 69) chain B residue 324 type sequence W description BINDING SITE FOR RESIDUE CAD B 951 source : BC4 70) chain B residue 384 type sequence C description BINDING SITE FOR RESIDUE CAD B 951 source : BC4 71) chain A residue 367 type sequence R description BINDING SITE FOR RESIDUE GOL A 890 source : BC5 72) chain A residue 449 type sequence W description BINDING SITE FOR RESIDUE GOL A 890 source : BC5 73) chain B residue 462 type sequence F description BINDING SITE FOR RESIDUE GOL A 890 source : BC5 74) chain A residue 462 type sequence F description BINDING SITE FOR RESIDUE GOL A 881 source : BC6 75) chain A residue 465 type sequence E description BINDING SITE FOR RESIDUE GOL A 881 source : BC6 76) chain B residue 104 type sequence S description BINDING SITE FOR RESIDUE GOL A 881 source : BC6 77) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE GOL A 881 source : BC6 78) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE GOL B 891 source : BC7 79) chain B residue 448 type sequence A description BINDING SITE FOR RESIDUE GOL B 891 source : BC7 80) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE GOL B 891 source : BC7 81) chain A residue 185-192 type prosite sequence RCVGRIQW description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW source prosite : PS60001 82) chain A residue 96 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 83) chain A residue 101 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 84) chain B residue 96 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 85) chain B residue 101 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 86) chain A residue 104 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 87) chain A residue 477 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 88) chain B residue 104 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 89) chain B residue 249 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 90) chain B residue 358 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 91) chain B residue 359 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 92) chain B residue 363 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 93) chain B residue 368 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 94) chain B residue 448 type BINDING sequence A description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 95) chain B residue 449 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 96) chain B residue 462 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 97) chain A residue 249 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 98) chain B residue 477 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 99) chain A residue 358 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 100) chain A residue 359 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 101) chain A residue 363 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 102) chain A residue 368 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 103) chain A residue 448 type BINDING sequence A description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 104) chain A residue 449 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 105) chain A residue 462 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 106) chain A residue 186 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI3 107) chain B residue 186 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI3 108) chain A residue 116 type MOD_RES sequence S description Phosphoserine; by CDK5 => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI4 109) chain B residue 116 type MOD_RES sequence S description Phosphoserine; by CDK5 => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI4

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