eF-site ID 1d1w-AB
PDB Code 1d1w
Chain A, B

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Title BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 2-AMINOTHIAZOLINE (H4B BOUND)
Classification OXIDOREDUCTASE
Compound NITRIC OXIDE SYNTHASE
Source Bos taurus (Bovine) (NOS3_BOVIN)
Sequence A:  GPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLV
LPRKLQTRPSPGPPPAEQLLSQARDFINQYYSSIKRSGSQ
AHEERLQEVEAEVASTGTYHLRESELVFGAKQAWRNAPRC
VGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNL
RSAITVFPQRAPGRGDFRIWNSQLVRYAGYRQQDGSVRGD
PANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEAPELFV
LPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIG
GLEFSAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMD
LDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIVDHHAAT
VSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEM
VNYILSPAFRYQPDPW
B:  KFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLP
RKLQTRPSPGPPPAEQLLSQARDFINQYYSSIKRSGSQAH
EERLQEVEAEVASTGTYHLRESELVFGAKQAWRNAPRCVG
RIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRS
AITVFPQRAPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPA
NVEITELCIQHGWTPGNGRFDVLPLLLQAPDEAPELFVLP
PELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGL
EFSAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLD
TRTTSSLWKDKAAVEINLAVLHSFQLAKVTIVDHHAATVS
FMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVN
YILSPAFRYQPDPW
Description


Functional site

1) chain A
residue 249
type
sequence Q
description BINDING SITE FOR RESIDUE ACT A 850
source : AC1

2) chain A
residue 252
type
sequence R
description BINDING SITE FOR RESIDUE ACT A 850
source : AC1

3) chain A
residue 368
type
sequence N
description BINDING SITE FOR RESIDUE ACT A 850
source : AC1

4) chain A
residue 374
type
sequence R
description BINDING SITE FOR RESIDUE ACT A 850
source : AC1

5) chain A
residue 358
type
sequence W
description BINDING SITE FOR RESIDUE ACT A 860
source : AC2

6) chain A
residue 420
type
sequence V
description BINDING SITE FOR RESIDUE ACT A 860
source : AC2

7) chain A
residue 428
type
sequence S
description BINDING SITE FOR RESIDUE ACT A 860
source : AC2

8) chain B
residue 249
type
sequence Q
description BINDING SITE FOR RESIDUE ACT B 851
source : AC3

9) chain B
residue 252
type
sequence R
description BINDING SITE FOR RESIDUE ACT B 851
source : AC3

10) chain B
residue 368
type
sequence N
description BINDING SITE FOR RESIDUE ACT B 851
source : AC3

11) chain B
residue 374
type
sequence R
description BINDING SITE FOR RESIDUE ACT B 851
source : AC3

12) chain B
residue 191
type
sequence Q
description BINDING SITE FOR RESIDUE ACT B 861
source : AC4

13) chain B
residue 358
type
sequence W
description BINDING SITE FOR RESIDUE ACT B 861
source : AC4

14) chain B
residue 420
type
sequence V
description BINDING SITE FOR RESIDUE ACT B 861
source : AC4

15) chain B
residue 428
type
sequence S
description BINDING SITE FOR RESIDUE ACT B 861
source : AC4

16) chain A
residue 96
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 900
source : AC5

17) chain A
residue 101
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 900
source : AC5

18) chain B
residue 96
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 900
source : AC5

19) chain B
residue 101
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 900
source : AC5

20) chain A
residue 180
type
sequence W
description BINDING SITE FOR RESIDUE HEM A 500
source : AC6

21) chain A
residue 185
type
sequence R
description BINDING SITE FOR RESIDUE HEM A 500
source : AC6

22) chain A
residue 186
type
sequence C
description BINDING SITE FOR RESIDUE HEM A 500
source : AC6

23) chain A
residue 228
type
sequence S
description BINDING SITE FOR RESIDUE HEM A 500
source : AC6

24) chain A
residue 341
type
sequence M
description BINDING SITE FOR RESIDUE HEM A 500
source : AC6

25) chain A
residue 355
type
sequence F
description BINDING SITE FOR RESIDUE HEM A 500
source : AC6

26) chain A
residue 356
type
sequence S
description BINDING SITE FOR RESIDUE HEM A 500
source : AC6

27) chain A
residue 358
type
sequence W
description BINDING SITE FOR RESIDUE HEM A 500
source : AC6

28) chain A
residue 363
type
sequence E
description BINDING SITE FOR RESIDUE HEM A 500
source : AC6

29) chain A
residue 449
type
sequence W
description BINDING SITE FOR RESIDUE HEM A 500
source : AC6

30) chain A
residue 477
type
sequence Y
description BINDING SITE FOR RESIDUE HEM A 500
source : AC6

31) chain A
residue 104
type
sequence S
description BINDING SITE FOR RESIDUE H4B A 600
source : AC7

32) chain A
residue 367
type
sequence R
description BINDING SITE FOR RESIDUE H4B A 600
source : AC7

33) chain A
residue 448
type
sequence A
description BINDING SITE FOR RESIDUE H4B A 600
source : AC7

34) chain A
residue 449
type
sequence W
description BINDING SITE FOR RESIDUE H4B A 600
source : AC7

35) chain B
residue 447
type
sequence W
description BINDING SITE FOR RESIDUE H4B A 600
source : AC7

36) chain B
residue 462
type
sequence F
description BINDING SITE FOR RESIDUE H4B A 600
source : AC7

37) chain B
residue 464
type
sequence Q
description BINDING SITE FOR RESIDUE H4B A 600
source : AC7

38) chain A
residue 358
type
sequence W
description BINDING SITE FOR RESIDUE ATQ A 805
source : AC8

39) chain A
residue 359
type
sequence Y
description BINDING SITE FOR RESIDUE ATQ A 805
source : AC8

40) chain A
residue 363
type
sequence E
description BINDING SITE FOR RESIDUE ATQ A 805
source : AC8

41) chain A
residue 324
type
sequence W
description BINDING SITE FOR RESIDUE CAD A 950
source : AC9

42) chain A
residue 384
type
sequence C
description BINDING SITE FOR RESIDUE CAD A 950
source : AC9

43) chain A
residue 438
type
sequence K
description BINDING SITE FOR RESIDUE CAD A 950
source : AC9

44) chain A
residue 440
type
sequence R
description BINDING SITE FOR RESIDUE CAD A 950
source : AC9

45) chain A
residue 441
type
sequence G
description BINDING SITE FOR RESIDUE CAD A 950
source : AC9

46) chain B
residue 180
type
sequence W
description BINDING SITE FOR RESIDUE HEM B 500
source : BC1

47) chain B
residue 186
type
sequence C
description BINDING SITE FOR RESIDUE HEM B 500
source : BC1

48) chain B
residue 228
type
sequence S
description BINDING SITE FOR RESIDUE HEM B 500
source : BC1

49) chain B
residue 341
type
sequence M
description BINDING SITE FOR RESIDUE HEM B 500
source : BC1

50) chain B
residue 355
type
sequence F
description BINDING SITE FOR RESIDUE HEM B 500
source : BC1

51) chain B
residue 356
type
sequence S
description BINDING SITE FOR RESIDUE HEM B 500
source : BC1

52) chain B
residue 358
type
sequence W
description BINDING SITE FOR RESIDUE HEM B 500
source : BC1

53) chain B
residue 363
type
sequence E
description BINDING SITE FOR RESIDUE HEM B 500
source : BC1

54) chain B
residue 477
type
sequence Y
description BINDING SITE FOR RESIDUE HEM B 500
source : BC1

55) chain A
residue 447
type
sequence W
description BINDING SITE FOR RESIDUE H4B B 601
source : BC2

56) chain A
residue 462
type
sequence F
description BINDING SITE FOR RESIDUE H4B B 601
source : BC2

57) chain A
residue 465
type
sequence E
description BINDING SITE FOR RESIDUE H4B B 601
source : BC2

58) chain B
residue 104
type
sequence S
description BINDING SITE FOR RESIDUE H4B B 601
source : BC2

59) chain B
residue 367
type
sequence R
description BINDING SITE FOR RESIDUE H4B B 601
source : BC2

60) chain B
residue 448
type
sequence A
description BINDING SITE FOR RESIDUE H4B B 601
source : BC2

61) chain B
residue 449
type
sequence W
description BINDING SITE FOR RESIDUE H4B B 601
source : BC2

62) chain B
residue 358
type
sequence W
description BINDING SITE FOR RESIDUE ATQ B 801
source : BC3

63) chain B
residue 359
type
sequence Y
description BINDING SITE FOR RESIDUE ATQ B 801
source : BC3

64) chain B
residue 363
type
sequence E
description BINDING SITE FOR RESIDUE ATQ B 801
source : BC3

65) chain B
residue 83
type
sequence Y
description BINDING SITE FOR RESIDUE CAD B 951
source : BC4

66) chain B
residue 324
type
sequence W
description BINDING SITE FOR RESIDUE CAD B 951
source : BC4

67) chain B
residue 384
type
sequence C
description BINDING SITE FOR RESIDUE CAD B 951
source : BC4

68) chain A
residue 106
type
sequence V
description BINDING SITE FOR RESIDUE GOL A 880
source : BC5

69) chain A
residue 367
type
sequence R
description BINDING SITE FOR RESIDUE GOL A 880
source : BC5

70) chain A
residue 373
type
sequence H
description BINDING SITE FOR RESIDUE GOL A 880
source : BC5

71) chain A
residue 449
type
sequence W
description BINDING SITE FOR RESIDUE GOL A 880
source : BC5

72) chain B
residue 76
type
sequence W
description BINDING SITE FOR RESIDUE GOL A 880
source : BC5

73) chain A
residue 263
type
sequence V
description BINDING SITE FOR RESIDUE GOL A 890
source : BC6

74) chain A
residue 264
type
sequence R
description BINDING SITE FOR RESIDUE GOL A 890
source : BC6

75) chain A
residue 265
type
sequence G
description BINDING SITE FOR RESIDUE GOL A 890
source : BC6

76) chain A
residue 287
type
sequence R
description BINDING SITE FOR RESIDUE GOL A 890
source : BC6

77) chain A
residue 374
type
sequence R
description BINDING SITE FOR RESIDUE GOL A 890
source : BC6

78) chain A
residue 375
type
sequence Y
description BINDING SITE FOR RESIDUE GOL A 890
source : BC6

79) chain A
residue 76
type
sequence W
description BINDING SITE FOR RESIDUE GOL B 881
source : BC7

80) chain B
residue 106
type
sequence V
description BINDING SITE FOR RESIDUE GOL B 881
source : BC7

81) chain B
residue 367
type
sequence R
description BINDING SITE FOR RESIDUE GOL B 881
source : BC7

82) chain B
residue 373
type
sequence H
description BINDING SITE FOR RESIDUE GOL B 881
source : BC7

83) chain B
residue 263
type
sequence V
description BINDING SITE FOR RESIDUE GOL B 891
source : BC8

84) chain B
residue 264
type
sequence R
description BINDING SITE FOR RESIDUE GOL B 891
source : BC8

85) chain B
residue 265
type
sequence G
description BINDING SITE FOR RESIDUE GOL B 891
source : BC8

86) chain B
residue 287
type
sequence R
description BINDING SITE FOR RESIDUE GOL B 891
source : BC8

87) chain B
residue 375
type
sequence Y
description BINDING SITE FOR RESIDUE GOL B 891
source : BC8

88) chain A
residue 185-192
type prosite
sequence RCVGRIQW
description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW
source prosite : PS60001

89) chain A
residue 96
type BINDING
sequence C
description BINDING => ECO:0000250|UniProtKB:P35228
source Swiss-Prot : SWS_FT_FI1

90) chain A
residue 101
type BINDING
sequence C
description BINDING => ECO:0000250|UniProtKB:P35228
source Swiss-Prot : SWS_FT_FI1

91) chain B
residue 96
type BINDING
sequence C
description BINDING => ECO:0000250|UniProtKB:P35228
source Swiss-Prot : SWS_FT_FI1

92) chain B
residue 101
type BINDING
sequence C
description BINDING => ECO:0000250|UniProtKB:P35228
source Swiss-Prot : SWS_FT_FI1

93) chain A
residue 104
type BINDING
sequence S
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI2

94) chain A
residue 477
type BINDING
sequence Y
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI2

95) chain B
residue 104
type BINDING
sequence S
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI2

96) chain B
residue 249
type BINDING
sequence Q
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI2

97) chain B
residue 358
type BINDING
sequence W
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI2

98) chain B
residue 359
type BINDING
sequence Y
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI2

99) chain B
residue 363
type BINDING
sequence E
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI2

100) chain B
residue 368
type BINDING
sequence N
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI2

101) chain B
residue 448
type BINDING
sequence A
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI2

102) chain B
residue 449
type BINDING
sequence W
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI2

103) chain B
residue 462
type BINDING
sequence F
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI2

104) chain A
residue 249
type BINDING
sequence Q
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI2

105) chain B
residue 477
type BINDING
sequence Y
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI2

106) chain A
residue 358
type BINDING
sequence W
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI2

107) chain A
residue 359
type BINDING
sequence Y
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI2

108) chain A
residue 363
type BINDING
sequence E
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI2

109) chain A
residue 368
type BINDING
sequence N
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI2

110) chain A
residue 448
type BINDING
sequence A
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI2

111) chain A
residue 449
type BINDING
sequence W
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI2

112) chain A
residue 462
type BINDING
sequence F
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI2

113) chain A
residue 186
type BINDING
sequence C
description axial binding residue => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI3

114) chain B
residue 186
type BINDING
sequence C
description axial binding residue => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI3

115) chain A
residue 116
type MOD_RES
sequence S
description Phosphoserine; by CDK5 => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI4

116) chain B
residue 116
type MOD_RES
sequence S
description Phosphoserine; by CDK5 => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI4


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