eF-site ID 1d1v-AB PDB Code 1d1v Chain A, B click to enlarge Title BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH S-ETHYL-N-PHENYL-ISOTHIOUREA (H4B BOUND) Classification OXIDOREDUCTASE Compound BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME Source Bos taurus (Bovine) (NOS3_BOVIN) Sequence A:  GPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLV LPRKLQTRPSPGPPPAEQLLSQARDFINQYYSSIKRSGSQ AHEERLQEVEAEVASTGTYHLRESELVFGAKQAWRNAPRC VGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNL RSAITVFPQRAPGRGDFRIWNSQLVRYAGYRQQDGSVRGD PANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEAPELFV LPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIG GLEFSAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMD LDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIVDHHAAT VSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEM VNYILSPAFRYQPDPW B:  KFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLP RKLQTRPSPGPPPAEQLLSQARDFINQYYSSIKRSGSQAH EERLQEVEAEVASTGTYHLRESELVFGAKQAWRNAPRCVG RIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRS AITVFPQRAPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPA NVEITELCIQHGWTPGNGRFDVLPLLLQAPDEAPELFVLP PELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGL EFSAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLD TRTTSSLWKDKAAVEINLAVLHSFQLAKVTIVDHHAATVS FMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVN YILSPAFRYQPDPW Description Functional site 1) chain A residue 252 type sequence R description BINDING SITE FOR RESIDUE ACT A 850 source : AC1 2) chain A residue 368 type sequence N description BINDING SITE FOR RESIDUE ACT A 850 source : AC1 3) chain A residue 374 type sequence R description BINDING SITE FOR RESIDUE ACT A 850 source : AC1 4) chain A residue 188 type sequence G description BINDING SITE FOR RESIDUE ACT A 860 source : AC2 5) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE ACT A 860 source : AC2 6) chain A residue 420 type sequence V description BINDING SITE FOR RESIDUE ACT A 860 source : AC2 7) chain A residue 428 type sequence S description BINDING SITE FOR RESIDUE ACT A 860 source : AC2 8) chain B residue 252 type sequence R description BINDING SITE FOR RESIDUE ACT B 851 source : AC3 9) chain B residue 368 type sequence N description BINDING SITE FOR RESIDUE ACT B 851 source : AC3 10) chain B residue 374 type sequence R description BINDING SITE FOR RESIDUE ACT B 851 source : AC3 11) chain B residue 188 type sequence G description BINDING SITE FOR RESIDUE ACT B 861 source : AC4 12) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE ACT B 861 source : AC4 13) chain B residue 420 type sequence V description BINDING SITE FOR RESIDUE ACT B 861 source : AC4 14) chain B residue 428 type sequence S description BINDING SITE FOR RESIDUE ACT B 861 source : AC4 15) chain A residue 96 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC5 16) chain A residue 101 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC5 17) chain B residue 96 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC5 18) chain B residue 101 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC5 19) chain A residue 180 type sequence W description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 20) chain A residue 185 type sequence R description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 21) chain A residue 186 type sequence C description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 22) chain A residue 228 type sequence S description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 23) chain A residue 355 type sequence F description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 24) chain A residue 356 type sequence S description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 25) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 26) chain A residue 363 type sequence E description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 27) chain A residue 449 type sequence W description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 28) chain A residue 477 type sequence Y description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 29) chain B residue 180 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 30) chain B residue 185 type sequence R description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 31) chain B residue 186 type sequence C description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 32) chain B residue 228 type sequence S description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 33) chain B residue 355 type sequence F description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 34) chain B residue 356 type sequence S description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 35) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 36) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 37) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 38) chain B residue 477 type sequence Y description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 39) chain A residue 104 type sequence S description BINDING SITE FOR RESIDUE H4B A 700 source : AC8 40) chain A residue 367 type sequence R description BINDING SITE FOR RESIDUE H4B A 700 source : AC8 41) chain A residue 448 type sequence A description BINDING SITE FOR RESIDUE H4B A 700 source : AC8 42) chain A residue 449 type sequence W description BINDING SITE FOR RESIDUE H4B A 700 source : AC8 43) chain B residue 447 type sequence W description BINDING SITE FOR RESIDUE H4B A 700 source : AC8 44) chain B residue 462 type sequence F description BINDING SITE FOR RESIDUE H4B A 700 source : AC8 45) chain B residue 463 type sequence H description BINDING SITE FOR RESIDUE H4B A 700 source : AC8 46) chain A residue 336 type sequence P description BINDING SITE FOR RESIDUE PTU A 810 source : AC9 47) chain A residue 338 type sequence V description BINDING SITE FOR RESIDUE PTU A 810 source : AC9 48) chain A residue 355 type sequence F description BINDING SITE FOR RESIDUE PTU A 810 source : AC9 49) chain A residue 357 type sequence G description BINDING SITE FOR RESIDUE PTU A 810 source : AC9 50) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE PTU A 810 source : AC9 51) chain A residue 359 type sequence Y description BINDING SITE FOR RESIDUE PTU A 810 source : AC9 52) chain A residue 363 type sequence E description BINDING SITE FOR RESIDUE PTU A 810 source : AC9 53) chain A residue 324 type sequence W description BINDING SITE FOR RESIDUE CAD A 950 source : BC1 54) chain A residue 384 type sequence C description BINDING SITE FOR RESIDUE CAD A 950 source : BC1 55) chain A residue 438 type sequence K description BINDING SITE FOR RESIDUE CAD A 950 source : BC1 56) chain A residue 440 type sequence R description BINDING SITE FOR RESIDUE CAD A 950 source : BC1 57) chain A residue 441 type sequence G description BINDING SITE FOR RESIDUE CAD A 950 source : BC1 58) chain A residue 447 type sequence W description BINDING SITE FOR RESIDUE H4B B 701 source : BC2 59) chain A residue 462 type sequence F description BINDING SITE FOR RESIDUE H4B B 701 source : BC2 60) chain B residue 104 type sequence S description BINDING SITE FOR RESIDUE H4B B 701 source : BC2 61) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE H4B B 701 source : BC2 62) chain B residue 448 type sequence A description BINDING SITE FOR RESIDUE H4B B 701 source : BC2 63) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE H4B B 701 source : BC2 64) chain B residue 336 type sequence P description BINDING SITE FOR RESIDUE PTU B 811 source : BC3 65) chain B residue 338 type sequence V description BINDING SITE FOR RESIDUE PTU B 811 source : BC3 66) chain B residue 355 type sequence F description BINDING SITE FOR RESIDUE PTU B 811 source : BC3 67) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE PTU B 811 source : BC3 68) chain B residue 359 type sequence Y description BINDING SITE FOR RESIDUE PTU B 811 source : BC3 69) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE PTU B 811 source : BC3 70) chain B residue 83 type sequence Y description BINDING SITE FOR RESIDUE CAD B 951 source : BC4 71) chain B residue 324 type sequence W description BINDING SITE FOR RESIDUE CAD B 951 source : BC4 72) chain B residue 384 type sequence C description BINDING SITE FOR RESIDUE CAD B 951 source : BC4 73) chain A residue 106 type sequence V description BINDING SITE FOR RESIDUE GOL A 880 source : BC5 74) chain A residue 367 type sequence R description BINDING SITE FOR RESIDUE GOL A 880 source : BC5 75) chain A residue 373 type sequence H description BINDING SITE FOR RESIDUE GOL A 880 source : BC5 76) chain A residue 449 type sequence W description BINDING SITE FOR RESIDUE GOL A 880 source : BC5 77) chain B residue 76 type sequence W description BINDING SITE FOR RESIDUE GOL A 880 source : BC5 78) chain A residue 76 type sequence W description BINDING SITE FOR RESIDUE GOL B 881 source : BC6 79) chain B residue 106 type sequence V description BINDING SITE FOR RESIDUE GOL B 881 source : BC6 80) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE GOL B 881 source : BC6 81) chain B residue 373 type sequence H description BINDING SITE FOR RESIDUE GOL B 881 source : BC6 82) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE GOL B 881 source : BC6 83) chain A residue 185-192 type prosite sequence RCVGRIQW description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW source prosite : PS60001 84) chain A residue 96 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 85) chain A residue 101 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 86) chain B residue 96 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 87) chain B residue 101 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 88) chain A residue 104 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 89) chain A residue 477 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 90) chain B residue 104 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 91) chain B residue 249 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 92) chain B residue 358 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 93) chain B residue 359 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 94) chain B residue 363 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 95) chain B residue 368 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 96) chain B residue 448 type BINDING sequence A description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 97) chain B residue 449 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 98) chain B residue 462 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 99) chain A residue 249 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 100) chain B residue 477 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 101) chain A residue 358 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 102) chain A residue 359 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 103) chain A residue 363 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 104) chain A residue 368 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 105) chain A residue 448 type BINDING sequence A description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 106) chain A residue 449 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 107) chain A residue 462 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 108) chain A residue 186 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI3 109) chain B residue 186 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI3 110) chain A residue 116 type MOD_RES sequence S description Phosphoserine; by CDK5 => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI4 111) chain B residue 116 type MOD_RES sequence S description Phosphoserine; by CDK5 => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI4

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