eF-site ID 1d1t-A PDB Code 1d1t Chain A click to enlarge Title MUTANT OF HUMAN SIGMA ALCOHOL DEHYDROGENASE WITH LEUCINE AT POSITION 141 Classification OXIDOREDUCTASE Compound ALCOHOL DEHYDROGENASE CLASS IV SIGMA CHAIN Source Homo sapiens (Human) (ADH7_HUMAN) Sequence A:  GTAGKVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKI LATGICRTDDHVIKGTMVSKFPVIVGHEATGIVESIGEGV TTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGRG VLADGTTRFTCKGKPVHHFLNTSTFTEYTVVDESSVAKID DAAPPEKVCLIGCGFSTGYGAAVKTGKVKPGSTCVVFGLG GVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECI SPKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALAS CHMNYGTSVVVGVPPSAKMLTYDPMLLFTGRTWKGCVFGG LKSRDDVPKLVTEFLAKKFDLDQLITHVLPFKKISEGFEL LNSGQSIRTVLTF Description Functional site 1) chain A residue 97 type sequence C description BINDING SITE FOR RESIDUE ZN A 375 source : AC1 2) chain A residue 100 type sequence C description BINDING SITE FOR RESIDUE ZN A 375 source : AC1 3) chain A residue 103 type sequence C description BINDING SITE FOR RESIDUE ZN A 375 source : AC1 4) chain A residue 111 type sequence C description BINDING SITE FOR RESIDUE ZN A 375 source : AC1 5) chain A residue 46 type sequence C description BINDING SITE FOR RESIDUE ZN A 376 source : AC2 6) chain A residue 67 type sequence H description BINDING SITE FOR RESIDUE ZN A 376 source : AC2 7) chain A residue 174 type sequence C description BINDING SITE FOR RESIDUE ZN A 376 source : AC2 8) chain A residue 271 type sequence H description BINDING SITE FOR RESIDUE ZN A 401 source : AC9 9) chain A residue 138 type sequence H description BINDING SITE FOR RESIDUE ZN A 402 source : BC1 10) chain A residue 357 type sequence E description BINDING SITE FOR RESIDUE ZN A 408 source : BC7 11) chain A residue 360 type sequence E description BINDING SITE FOR RESIDUE ZN A 408 source : BC7 12) chain A residue 46 type sequence C description BINDING SITE FOR RESIDUE ACT A 501 source : CC2 13) chain A residue 48 type sequence T description BINDING SITE FOR RESIDUE ACT A 501 source : CC2 14) chain A residue 67 type sequence H description BINDING SITE FOR RESIDUE ACT A 501 source : CC2 15) chain A residue 93 type sequence F description BINDING SITE FOR RESIDUE ACT A 501 source : CC2 16) chain A residue 141 type sequence L description BINDING SITE FOR RESIDUE ACT A 501 source : CC2 17) chain A residue 174 type sequence C description BINDING SITE FOR RESIDUE ACT A 501 source : CC2 18) chain A residue 294 type sequence V description BINDING SITE FOR RESIDUE ACT A 501 source : CC2 19) chain A residue 60 type sequence K description BINDING SITE FOR RESIDUE ACT A 502 source : CC3 20) chain A residue 138 type sequence H description BINDING SITE FOR RESIDUE ACT A 502 source : CC3 21) chain A residue 224 type sequence L description BINDING SITE FOR RESIDUE ACT A 504 source : CC4 22) chain A residue 138 type sequence H description BINDING SITE FOR RESIDUE ACT A 513 source : DC4 23) chain A residue 233 type sequence M description BINDING SITE FOR RESIDUE CAC A 994 source : DC9 24) chain A residue 237 type sequence A description BINDING SITE FOR RESIDUE CAC A 994 source : DC9 25) chain A residue 259 type sequence G description BINDING SITE FOR RESIDUE CAC B 995 source : EC1 26) chain A residue 260 type sequence N description BINDING SITE FOR RESIDUE CAC B 995 source : EC1 27) chain A residue 47 type sequence R description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 28) chain A residue 48 type sequence T description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 29) chain A residue 51 type sequence H description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 30) chain A residue 174 type sequence C description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 31) chain A residue 178 type sequence T description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 32) chain A residue 201 type sequence G description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 33) chain A residue 202 type sequence G description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 34) chain A residue 203 type sequence V description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 35) chain A residue 223 type sequence D description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 36) chain A residue 224 type sequence L description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 37) chain A residue 228 type sequence K description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 38) chain A residue 268 type sequence V description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 39) chain A residue 269 type sequence I description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 40) chain A residue 270 type sequence G description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 41) chain A residue 271 type sequence H description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 42) chain A residue 292 type sequence V description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 43) chain A residue 293 type sequence G description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 44) chain A residue 294 type sequence V description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 45) chain A residue 317 type sequence C description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 46) chain A residue 319 type sequence F description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 47) chain A residue 369 type sequence R description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 48) chain A residue 309 type sequence F description BINDING SITE FOR RESIDUE NAD B 2377 source : EC3 49) chain A residue 66-80 type prosite sequence GHEATGIVESIGEGV description ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEaTGIvesiGegV source prosite : PS00059 50) chain A residue 59 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 51) chain A residue 236 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 52) chain A residue 241 type BINDING sequence I description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 53) chain A residue 282 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 54) chain A residue 305 type BINDING sequence P description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 55) chain A residue 330 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 56) chain A residue 369 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 57) chain A residue 60 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 58) chain A residue 80 type BINDING sequence V description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 59) chain A residue 110 type BINDING sequence L description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 60) chain A residue 113 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 61) chain A residue 116 type BINDING sequence I description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 62) chain A residue 125 type BINDING sequence D description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 63) chain A residue 187 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 64) chain A residue 212 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1

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