eF-site ID 1d1s-A PDB Code 1d1s Chain A click to enlarge Title WILD-TYPE HUMAN SIGMA (CLASS IV) ALCOHOL DEHYDROGENASE Classification OXIDOREDUCTASE Compound ALCOHOL DEHYDROGENASE CLASS IV SIGMA CHAIN Source Homo sapiens (Human) (ADH7_HUMAN) Sequence A:  GTAGKVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKI LATGICRTDDHVIKGTMVSKFPVIVGHEATGIVESIGEGV TTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGRG VLADGTTRFTCKGKPVHHFMNTSTFTEYTVVDESSVAKID DAAPPEKVCLIGCGFSTGYGAAVKTGKVKPGSTCVVFGLG GVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECI SPKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALAS CHMNYGTSVVVGVPPSAKMLTYDPMLLFTGRTWKGCVFGG LKSRDDVPKLVTEFLAKKFDLDQLITHVLPFKKISEGFEL LNSGQSIRTVLTF Description Functional site 1) chain A residue 97 type sequence C description BINDING SITE FOR RESIDUE ZN A 375 source : AC1 2) chain A residue 100 type sequence C description BINDING SITE FOR RESIDUE ZN A 375 source : AC1 3) chain A residue 103 type sequence C description BINDING SITE FOR RESIDUE ZN A 375 source : AC1 4) chain A residue 111 type sequence C description BINDING SITE FOR RESIDUE ZN A 375 source : AC1 5) chain A residue 46 type sequence C description BINDING SITE FOR RESIDUE ZN A 376 source : AC2 6) chain A residue 67 type sequence H description BINDING SITE FOR RESIDUE ZN A 376 source : AC2 7) chain A residue 174 type sequence C description BINDING SITE FOR RESIDUE ZN A 376 source : AC2 8) chain A residue 271 type sequence H description BINDING SITE FOR RESIDUE ZN A 401 source : AC9 9) chain A residue 138 type sequence H description BINDING SITE FOR RESIDUE ZN A 402 source : BC1 10) chain A residue 357 type sequence E description BINDING SITE FOR RESIDUE ZN A 408 source : BC7 11) chain A residue 360 type sequence E description BINDING SITE FOR RESIDUE ZN A 408 source : BC7 12) chain A residue 48 type sequence T description BINDING SITE FOR RESIDUE ACT A 501 source : CC2 13) chain A residue 93 type sequence F description BINDING SITE FOR RESIDUE ACT A 501 source : CC2 14) chain A residue 294 type sequence V description BINDING SITE FOR RESIDUE ACT A 501 source : CC2 15) chain A residue 60 type sequence K description BINDING SITE FOR RESIDUE ACT A 502 source : CC3 16) chain A residue 122 type sequence V description BINDING SITE FOR RESIDUE ACT A 502 source : CC3 17) chain A residue 138 type sequence H description BINDING SITE FOR RESIDUE ACT A 502 source : CC3 18) chain A residue 271 type sequence H description BINDING SITE FOR RESIDUE ACT A 504 source : CC4 19) chain A residue 138 type sequence H description BINDING SITE FOR RESIDUE ACT A 513 source : DC4 20) chain A residue 233 type sequence M description BINDING SITE FOR RESIDUE CAC A 554 source : DC9 21) chain A residue 237 type sequence A description BINDING SITE FOR RESIDUE CAC A 554 source : DC9 22) chain A residue 259 type sequence G description BINDING SITE FOR RESIDUE CAC B 555 source : EC1 23) chain A residue 260 type sequence N description BINDING SITE FOR RESIDUE CAC B 555 source : EC1 24) chain A residue 47 type sequence R description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 25) chain A residue 48 type sequence T description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 26) chain A residue 51 type sequence H description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 27) chain A residue 174 type sequence C description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 28) chain A residue 178 type sequence T description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 29) chain A residue 201 type sequence G description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 30) chain A residue 202 type sequence G description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 31) chain A residue 203 type sequence V description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 32) chain A residue 223 type sequence D description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 33) chain A residue 224 type sequence L description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 34) chain A residue 228 type sequence K description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 35) chain A residue 268 type sequence V description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 36) chain A residue 269 type sequence I description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 37) chain A residue 271 type sequence H description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 38) chain A residue 292 type sequence V description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 39) chain A residue 293 type sequence G description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 40) chain A residue 294 type sequence V description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 41) chain A residue 317 type sequence C description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 42) chain A residue 319 type sequence F description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 43) chain A residue 369 type sequence R description BINDING SITE FOR RESIDUE NAD A 1377 source : EC2 44) chain A residue 309 type sequence F description BINDING SITE FOR RESIDUE NAD B 2377 source : EC3 45) chain A residue 46 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 46) chain A residue 223 type BINDING sequence D description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 47) chain A residue 228 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 48) chain A residue 269 type BINDING sequence I description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 49) chain A residue 292 type BINDING sequence V description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 50) chain A residue 317 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 51) chain A residue 369 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 52) chain A residue 47 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 53) chain A residue 67 type BINDING sequence H description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 54) chain A residue 97 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 55) chain A residue 100 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 56) chain A residue 103 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 57) chain A residue 111 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 58) chain A residue 174 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 59) chain A residue 199 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 60) chain A residue 66-80 type prosite sequence GHEATGIVESIGEGV description ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEaTGIvesiGegV source prosite : PS00059

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