eF-site ID 1d0v-A PDB Code 1d0v Chain A click to enlarge Title CRYSTAL STRUCTURE OF NICOTINATE MONONUCLEOTIDE:5,6-DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE (COBT) FROM SALMONELLA TYPHIMURIUM COMPLEXED WITH ITS REACTION PRODUCTS DETERMINED TO 1.9 A RESOLUTION Classification TRANSFERASE Compound NICOTINATE MONONUCLEOTIDE:5,6-DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE Source ORGANISM_SCIENTIFIC: Salmonella typhimurium; Sequence A:  LHALLRDIPAPDAEAMARTQQHIDGLLKPPGSLGRLETLA VQLAGMPGLNGTPQVGEKAVLVMCADHGVWDEGVAVSPKI VTAIQAANMTRGTTGVCVLAAQAGAKVHVIDVGIDAEPIP GVVNMRVARGCGNIAVGPAMSRLQAEALLLEVSRYACDLA QRGVTLFGVGELGMANTTPAAAMVSVFTGSDAKEVVGIGA NLPPSRIDNKVDVVRRAIAINQPNPRDGIDVLSKVGGFDL VGMTGVMLGAARCGLPVLLDGFLSYSAALAACQIAPAVRP YLIPSHFSAEKGARIALAHLSMEPYLHMAMRLGEGSGAAL AMPIVEAACAMFHNMGELAASNIVLP Description (1)  NICOTINATE MONONUCLEOTIDE:5,6-DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE (E.C.2.4.2.21) Functional site 1) chain A residue 32 type sequence P description BINDING SITE FOR RESIDUE RBZ A 990 source : AC1 2) chain A residue 80 type sequence S description BINDING SITE FOR RESIDUE RBZ A 990 source : AC1 3) chain A residue 174 type sequence E description BINDING SITE FOR RESIDUE RBZ A 990 source : AC1 4) chain A residue 175 type sequence L description BINDING SITE FOR RESIDUE RBZ A 990 source : AC1 5) chain A residue 176 type sequence G description BINDING SITE FOR RESIDUE RBZ A 990 source : AC1 6) chain A residue 177 type sequence M description BINDING SITE FOR RESIDUE RBZ A 990 source : AC1 7) chain A residue 178 type sequence A description BINDING SITE FOR RESIDUE RBZ A 990 source : AC1 8) chain A residue 179 type sequence N description BINDING SITE FOR RESIDUE RBZ A 990 source : AC1 9) chain A residue 180 type sequence T description BINDING SITE FOR RESIDUE RBZ A 990 source : AC1 10) chain A residue 202 type sequence G description BINDING SITE FOR RESIDUE RBZ A 990 source : AC1 11) chain A residue 203 type sequence A description BINDING SITE FOR RESIDUE RBZ A 990 source : AC1 12) chain A residue 315 type sequence L description BINDING SITE FOR RESIDUE RBZ A 990 source : AC1 13) chain A residue 317 type sequence E description BINDING SITE FOR RESIDUE RBZ A 990 source : AC1 14) chain A residue 264 type sequence G description BINDING SITE FOR RESIDUE NIO A 991 source : AC2 15) chain A residue 265 type sequence F description BINDING SITE FOR RESIDUE NIO A 991 source : AC2 16) chain A residue 266 type sequence L description BINDING SITE FOR RESIDUE NIO A 991 source : AC2 17) chain A residue 291 type sequence S description BINDING SITE FOR RESIDUE NIO A 991 source : AC2 18) chain A residue 314 type sequence R description BINDING SITE FOR RESIDUE NIO A 991 source : AC2 19) chain A residue 315 type sequence L description BINDING SITE FOR RESIDUE NIO A 991 source : AC2 20) chain A residue 316 type sequence G description BINDING SITE FOR RESIDUE NIO A 991 source : AC2 21) chain A residue 174 type catalytic sequence E description 79 source MCSA : MCSA1 22) chain A residue 317 type catalytic sequence E description 79 source MCSA : MCSA1 23) chain A residue 88 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:11441022 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 174 type BINDING sequence E description BINDING => ECO:0000269|PubMed:24121107, ECO:0000269|DOI:10.1074/jbc.M203535200 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 203 type BINDING sequence A description BINDING => ECO:0000269|PubMed:24121107, ECO:0000269|DOI:10.1074/jbc.M203535200 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 265 type BINDING sequence F description BINDING => ECO:0000269|PubMed:24121107, ECO:0000269|DOI:10.1074/jbc.M203535200 source Swiss-Prot : SWS_FT_FI2 27) chain A residue 291 type BINDING sequence S description BINDING => ECO:0000269|PubMed:24121107, ECO:0000269|DOI:10.1074/jbc.M203535200 source Swiss-Prot : SWS_FT_FI2 28) chain A residue 314 type BINDING sequence R description BINDING => ECO:0000269|PubMed:24121107, ECO:0000269|DOI:10.1074/jbc.M203535200 source Swiss-Prot : SWS_FT_FI2 29) chain A residue 174 type SITE sequence E description Important for substrate positioning, might be proton acceptor => ECO:0000269|PubMed:24121107 source Swiss-Prot : SWS_FT_FI3 30) chain A residue 317 type SITE sequence E description Important for substrate positioning, might be proton acceptor => ECO:0000269|PubMed:24121107, ECO:0000305|PubMed:10587435, ECO:0000305|DOI:10.1074/jbc.M203535200 source Swiss-Prot : SWS_FT_FI4

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