eF-site ID 1cza-N
PDB Code 1cza
Chain N

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Title MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE, GLUCOSE-6-PHOSPHATE, AND ADP
Classification TRANSFERASE
Compound HEXOKINASE TYPE I
Source (HXK1_HUMAN)
Sequence N:  DDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDF
NPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRV
QVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLG
DFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRF
KASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMM
TCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRM
CINTEWGAFGDDGSLEDIRTEFDRAIDAYSLNPGKQLFEK
MVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFN
TSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVC
TIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGS
LYKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAM
VTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEM
ELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGG
TNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELF
DHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGI
LITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVV
NDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEM
VEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLN
AGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISET
LKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDD
SILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLN
VTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSED
GSGKGAALITAVGVRLRT
Description


Functional site

1) chain N
residue 539
type catalytic
sequence R
description 696
source MCSA : MCSA1

2) chain N
residue 603
type catalytic
sequence S
description 696
source MCSA : MCSA1

3) chain N
residue 657
type catalytic
sequence D
description 696
source MCSA : MCSA1

4) chain N
residue 150-175
type prosite
sequence VGFTFSFPCQQSKIDEAILITWTKRF
description HEXOKINASE_1 Hexokinase domain signature. VGFTFSFPcqqskIDeaiLitWTKrF
source prosite : PS00378

5) chain N
residue 598-623
type prosite
sequence LGFTFSFPCQQTSLDAGILITWTKGF
description HEXOKINASE_1 Hexokinase domain signature. VGFTFSFPcqqskIDeaiLitWTKrF
source prosite : PS00378

6) chain N
residue 30
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1QHA
source Swiss-Prot : SWS_FT_FI1

7) chain N
residue 425
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1QHA
source Swiss-Prot : SWS_FT_FI1

8) chain N
residue 155
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0000269|PubMed:9735292, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1HKC, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA
source Swiss-Prot : SWS_FT_FI3

9) chain N
residue 532
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA
source Swiss-Prot : SWS_FT_FI8

10) chain N
residue 603
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI9

11) chain N
residue 620
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI10

12) chain N
residue 656
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI10

13) chain N
residue 682
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI10

14) chain N
residue 708
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI10

15) chain N
residue 742
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI10

16) chain N
residue 657
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA
source Swiss-Prot : SWS_FT_FI11

17) chain N
residue 747
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:10686099, ECO:0007744|PDB:1DGK
source Swiss-Prot : SWS_FT_FI12

18) chain N
residue 784
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:10686099, ECO:0007744|PDB:1DGK
source Swiss-Prot : SWS_FT_FI12

19) chain N
residue 337
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P05708
source Swiss-Prot : SWS_FT_FI15

20) chain N
residue 84
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9735292, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKC
source Swiss-Prot : SWS_FT_FI2

21) chain N
residue 863
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9735292, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKC
source Swiss-Prot : SWS_FT_FI2

22) chain N
residue 172
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0000269|PubMed:9735292, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1HKC, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI4

23) chain N
residue 208
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0000269|PubMed:9735292, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1HKC, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI4

24) chain N
residue 235
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0000269|PubMed:9735292, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1HKC, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI4

25) chain N
residue 260
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0000269|PubMed:9735292, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1HKC, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI4

26) chain N
residue 291
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0000269|PubMed:9735292, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1HKC, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI4

27) chain N
residue 209
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA
source Swiss-Prot : SWS_FT_FI5

28) chain N
residue 345
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:10574795, ECO:0007744|PDB:1QHA
source Swiss-Prot : SWS_FT_FI7

29) chain N
residue 897
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI13

30) chain N
residue 232
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI6

31) chain N
residue 413
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI6

32) chain N
residue 449
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI6

33) chain N
residue 680
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI6

34) chain N
residue 861
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI6


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