eF-site ID 1cz8-HLVWXY PDB Code 1cz8 Chain H, L, V, W, X, Y click to enlarge Title VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY Classification IMMUNE SYSTEM Compound Vascular endothelial growth factor A Source Homo sapiens (Human) (1CZ8) Sequence H:  EVQLVESGGGLVQPGGSLRLSCAASGYDFTHYGMNWVRQA PGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAY LQMNSLRAEDTAVYYCAKYPYYYGTSHWYFDVWGQGTLVT VSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNS GALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC NVNHKPSNTKVDKKVEPK L:  DIQLTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKP GKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQP EDFATYYCQQYSTVPWTFGQGTKVEIKRTVAAPSVFIFPP SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG LSSPVTKSFNRGE V:  VVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVP LMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGE MSFLQHNKCECRPK W:  VVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVP LMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGE MSFLQHNKCECRPK X:  DIQLTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKP GKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQP EDFATYYCQQYSTVPWTFGQGTKVEIKRTVAAPSVFIFPP SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG LSSPVTKSFNRGE Y:  EVQLVESGGGLVQPGGSLRLSCAASGYDFTHYGMNWVRQA PGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAY LQMNSLRAEDTAVYYCAKYPYYYGTSHWYFDVWGQGTLVT VSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNS GALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC NVNHKPSNTKVDKKVEPK Description (1)  VASCULAR ENDOTHELIAL GROWTH FACTOR/LIGHT CHAIN OF NEUTRALIZING ANTIBODY/HEAVY CHAIN OF NEUTRALIZING ANTIBODY COMPLEX Functional site 1) chain H residue 27 type sequence Y description BINDING SITE FOR RESIDUE SO4 H 301 source : AC1 2) chain H residue 28 type sequence D description BINDING SITE FOR RESIDUE SO4 H 301 source : AC1 3) chain H residue 31 type sequence H description BINDING SITE FOR RESIDUE SO4 H 301 source : AC1 4) chain H residue 32 type sequence Y description BINDING SITE FOR RESIDUE SO4 H 301 source : AC1 5) chain W residue 91 type sequence I description BINDING SITE FOR RESIDUE SO4 H 301 source : AC1 6) chain V residue 91 type sequence I description BINDING SITE FOR RESIDUE SO4 Y 301 source : AC2 7) chain Y residue 28 type sequence D description BINDING SITE FOR RESIDUE SO4 Y 301 source : AC2 8) chain Y residue 32 type sequence Y description BINDING SITE FOR RESIDUE SO4 Y 301 source : AC2 9) chain V residue 49-61 type prosite sequence PSCVPLMRCGGCC description PDGF_1 Platelet-derived growth factor (PDGF) family signature. PSCVplmRCGGCC source prosite : PS00249 10) chain L residue 192-198 type prosite sequence YACEVTH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH source prosite : PS00290 11) chain H residue 204-210 type prosite sequence YICNVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH source prosite : PS00290

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