|
|
eF-site ID
|
1cy9-B |
|
PDB Code
|
1cy9 |
|
Chain
|
B |
|
click to enlarge
|
|
|
Title
|
CRYSTAL STRUCTURE OF THE 30 KDA FRAGMENT OF E. COLI DNA TOPOISOMERASE I. MONOCLINIC FORM |
|
Classification
|
ISOMERASE |
|
Compound
|
DNA TOPOISOMERASE I |
|
Source
|
(TOP1_ECOLI) |
|
|
Sequence
|
B: |
PEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQ
AAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAST
RLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMV
RGYISDNFGKKYLPESPNQYASHEAIRPSDVNVMAESLKD
MEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRL
KARGRILRFDGWTKVMPDRILPAVNKGDALTLVELTPAQH
FTK
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
319 |
| type |
catalytic |
| sequence |
Y
|
| description |
366
|
| source |
MCSA : MCSA2
|
|
|
2)
|
chain |
B |
| residue |
321 |
| type |
catalytic |
| sequence |
R
|
| description |
366
|
| source |
MCSA : MCSA2
|
|
|
3)
|
chain |
B |
| residue |
365 |
| type |
catalytic |
| sequence |
H
|
| description |
366
|
| source |
MCSA : MCSA2
|
|
|
4)
|
chain |
B |
| residue |
321 |
| type |
SITE |
| sequence |
R
|
| description |
Interaction with DNA
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
B |
| residue |
319 |
| type |
ACT_SITE |
| sequence |
Y
|
| description |
O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01383, ECO:0000269|PubMed:21482796, ECO:0000269|PubMed:8114910, ECO:0000269|PubMed:9497321
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|