eF-site ID 1cw3-B PDB Code 1cw3 Chain B click to enlarge Title HUMAN MITOCHONDRIAL ALDEHYDE DEHYDROGENASE COMPLEXED WITH NAD+ AND MN2+ Classification OXIDOREDUCTASE Compound MITOCHONDRIAL ALDEHYDE DEHYDROGENASE Source null (ALDH2_HUMAN) Sequence B:  AVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGE VICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGR LLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVL KCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQII PWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVAN LIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGS TEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWA VEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARA KSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAK LLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQ ILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQAL QAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYT EVKTVTVKVPQKNS Description Functional site 1) chain B residue 39 type sequence T description BINDING SITE FOR RESIDUE MG B 2501 source : BC1 2) chain B residue 40 type sequence V description BINDING SITE FOR RESIDUE MG B 2501 source : BC1 3) chain B residue 109 type sequence D description BINDING SITE FOR RESIDUE MG B 2501 source : BC1 4) chain B residue 196 type sequence Q description BINDING SITE FOR RESIDUE MG B 2501 source : BC1 5) chain B residue 165 type sequence I description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 6) chain B residue 166 type sequence I description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 7) chain B residue 167 type sequence P description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 8) chain B residue 168 type sequence W description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 9) chain B residue 169 type sequence N description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 10) chain B residue 192 type sequence K description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 11) chain B residue 194 type sequence A description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 12) chain B residue 195 type sequence E description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 13) chain B residue 225 type sequence G description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 14) chain B residue 229 type sequence G description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 15) chain B residue 230 type sequence A description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 16) chain B residue 243 type sequence F description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 17) chain B residue 244 type sequence T description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 18) chain B residue 245 type sequence G description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 19) chain B residue 246 type sequence S description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 20) chain B residue 249 type sequence I description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 21) chain B residue 253 type sequence I description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 22) chain B residue 268 type sequence E description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 23) chain B residue 269 type sequence L description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 24) chain B residue 270 type sequence G description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 25) chain B residue 302 type sequence C description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 26) chain B residue 399 type sequence E description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 27) chain B residue 401 type sequence F description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 28) chain B residue 427 type sequence L description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 29) chain B residue 465 type sequence F description BINDING SITE FOR RESIDUE NAD B 2502 source : BC9 30) chain B residue 192 type catalytic sequence K description 803 source MCSA : MCSA2 31) chain B residue 268 type catalytic sequence E description 803 source MCSA : MCSA2 32) chain B residue 302 type catalytic sequence C description 803 source MCSA : MCSA2 33) chain B residue 399 type catalytic sequence E description 803 source MCSA : MCSA2 34) chain B residue 268 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI1 35) chain B residue 169 type SITE sequence N description Transition state stabilizer => ECO:0000250|UniProtKB:P20000 source Swiss-Prot : SWS_FT_FI4 36) chain B residue 35 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P47738 source Swiss-Prot : SWS_FT_FI5 37) chain B residue 56 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P47738 source Swiss-Prot : SWS_FT_FI5 38) chain B residue 61 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P47738 source Swiss-Prot : SWS_FT_FI5 39) chain B residue 142 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P47738 source Swiss-Prot : SWS_FT_FI5 40) chain B residue 351 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P47738 source Swiss-Prot : SWS_FT_FI5 41) chain B residue 366 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P47738 source Swiss-Prot : SWS_FT_FI5 42) chain B residue 409 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P47738 source Swiss-Prot : SWS_FT_FI5 43) chain B residue 411 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P47738 source Swiss-Prot : SWS_FT_FI5 44) chain B residue 434 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P47738 source Swiss-Prot : SWS_FT_FI5 45) chain B residue 302 type ACT_SITE sequence C description Nucleophile source Swiss-Prot : SWS_FT_FI2 46) chain B residue 245 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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