eF-site ID 1cvw-H PDB Code 1cvw Chain H click to enlarge Title Crystal structure of active site-inhibited human coagulation factor VIIA (DES-GLA) Classification HYDROLASE/HYDROLASE INHIBITOR Compound COAGULATION FACTOR VIIA (LIGHT CHAIN) (DES-GLA) Source null (FA7_HUMAN) Sequence H:  IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAA HCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPS TYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERT LAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQ QSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHY RGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMR SEPRPGVLLRAPFP Description (1)  COAGULATION FACTOR VIIA (LIGHT CHAIN)/COAGULATION FACTOR VIIA (HEAVY CHAIN) (E.C.3.4.21.21) Functional site 1) chain H residue 57 type sequence H description BINDING SITE FOR RESIDUE 0GE H 301 source : AC1 2) chain H residue 170 type sequence Q description BINDING SITE FOR RESIDUE 0GE H 301 source : AC1 3) chain H residue 189 type sequence D description BINDING SITE FOR RESIDUE 0GE H 301 source : AC1 4) chain H residue 190 type sequence S description BINDING SITE FOR RESIDUE 0GE H 301 source : AC1 5) chain H residue 192 type sequence K description BINDING SITE FOR RESIDUE 0GE H 301 source : AC1 6) chain H residue 193 type sequence G description BINDING SITE FOR RESIDUE 0GE H 301 source : AC1 7) chain H residue 195 type sequence S description BINDING SITE FOR RESIDUE 0GE H 301 source : AC1 8) chain H residue 214 type sequence S description BINDING SITE FOR RESIDUE 0GE H 301 source : AC1 9) chain H residue 215 type sequence W description BINDING SITE FOR RESIDUE 0GE H 301 source : AC1 10) chain H residue 216 type sequence G description BINDING SITE FOR RESIDUE 0GE H 301 source : AC1 11) chain H residue 217 type sequence Q description BINDING SITE FOR RESIDUE 0GE H 301 source : AC1 12) chain H residue 219 type sequence G description BINDING SITE FOR RESIDUE 0GE H 301 source : AC1 13) chain H residue 70 type sequence E description BINDING SITE FOR RESIDUE CA H 302 source : AC2 14) chain H residue 72 type sequence D description BINDING SITE FOR RESIDUE CA H 302 source : AC2 15) chain H residue 75 type sequence E description BINDING SITE FOR RESIDUE CA H 302 source : AC2 16) chain H residue 80 type sequence E description BINDING SITE FOR RESIDUE CA H 302 source : AC2 17) chain H residue 57 type ACT_SITE sequence H description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 18) chain H residue 102 type ACT_SITE sequence D description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 19) chain H residue 195 type ACT_SITE sequence S description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 20) chain H residue 189 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 21) chain H residue 175 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:3264725 source Swiss-Prot : SWS_FT_FI3 22) chain H residue 53-58 type prosite sequence VSAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC source prosite : PS00134 23) chain H residue 189-200 type prosite sequence DSCKGDSGGPHA description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPHA source prosite : PS00135

Display surface Download Links