eF-site ID 1cul-ABC
PDB Code 1cul
Chain A, B, C

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Title COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2',5'-DIDEOXY-ADENOSINE 3'-TRIPHOSPHATE AND MG
Classification Lyase/Lyase/Signaling protein
Compound TYPE V ADENYLYL CYCLASE
Source Canis familiaris (Dog) (Canis lupus familiaris) (GNAS_BOVIN)
Sequence A:  MMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTL
NELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHA
HCCVEMGMDMIEAISLVREMTGVNVNMRVGIHSGRVHCGV
LGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLSYL
NGDYEVEPGCGGERNAYLKEHSIETFLIL
B:  YHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNE
IIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAERQYM
HIGTMVEFAYALVGKLDAINKHSFNDFKLRVGINHGPVIA
GVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSL
ILQTLGYTCTCRGIINVKGKGDLKTYFVNT
C:  ATHRLLLLGAGESGKSTIVKQMRILHVGEKATKVQDIKNN
LKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVP
DFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYF
LDKIDVIKQDDYVPSDQDLLRCRVLTSGIFETKFQVDKVN
FHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIR
EDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLA
EKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAK
YFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFND
CRDIIQRM
Description


Functional site
1) chain A
residue 396
type
sequence D
description BINDING SITE FOR RESIDUE MG A 1006
source : AC1
2) chain A
residue 397
type
sequence I
description BINDING SITE FOR RESIDUE MG A 1006
source : AC1
3) chain A
residue 440
type
sequence D
description BINDING SITE FOR RESIDUE MG A 1006
source : AC1
4) chain A
residue 396
type
sequence D
description BINDING SITE FOR RESIDUE MG A 1007
source : AC2
5) chain A
residue 440
type
sequence D
description BINDING SITE FOR RESIDUE MG A 1007
source : AC2
6) chain C
residue 54
type
sequence S
description BINDING SITE FOR RESIDUE MG C 396
source : AC3
7) chain C
residue 204
type
sequence T
description BINDING SITE FOR RESIDUE MG C 396
source : AC3
8) chain C
residue 51
type
sequence S
description BINDING SITE FOR RESIDUE CL C 397
source : AC4
9) chain C
residue 249
type
sequence A
description BINDING SITE FOR RESIDUE CL C 397
source : AC4
10) chain C
residue 373
type
sequence R
description BINDING SITE FOR RESIDUE CL C 398
source : AC5
11) chain C
residue 373
type
sequence R
description BINDING SITE FOR RESIDUE CL C 398
source : AC5
12) chain C
residue 49
type
sequence G
description BINDING SITE FOR RESIDUE GSP C 395
source : AC6
13) chain C
residue 50
type
sequence E
description BINDING SITE FOR RESIDUE GSP C 395
source : AC6
14) chain C
residue 51
type
sequence S
description BINDING SITE FOR RESIDUE GSP C 395
source : AC6
15) chain C
residue 52
type
sequence G
description BINDING SITE FOR RESIDUE GSP C 395
source : AC6
16) chain C
residue 53
type
sequence K
description BINDING SITE FOR RESIDUE GSP C 395
source : AC6
17) chain C
residue 54
type
sequence S
description BINDING SITE FOR RESIDUE GSP C 395
source : AC6
18) chain C
residue 55
type
sequence T
description BINDING SITE FOR RESIDUE GSP C 395
source : AC6
19) chain C
residue 173
type
sequence D
description BINDING SITE FOR RESIDUE GSP C 395
source : AC6
20) chain C
residue 198
type
sequence L
description BINDING SITE FOR RESIDUE GSP C 395
source : AC6
21) chain C
residue 199
type
sequence R
description BINDING SITE FOR RESIDUE GSP C 395
source : AC6
22) chain C
residue 201
type
sequence R
description BINDING SITE FOR RESIDUE GSP C 395
source : AC6
23) chain C
residue 204
type
sequence T
description BINDING SITE FOR RESIDUE GSP C 395
source : AC6
24) chain C
residue 226
type
sequence G
description BINDING SITE FOR RESIDUE GSP C 395
source : AC6
25) chain C
residue 292
type
sequence N
description BINDING SITE FOR RESIDUE GSP C 395
source : AC6
26) chain C
residue 293
type
sequence K
description BINDING SITE FOR RESIDUE GSP C 395
source : AC6
27) chain C
residue 295
type
sequence D
description BINDING SITE FOR RESIDUE GSP C 395
source : AC6
28) chain C
residue 296
type
sequence L
description BINDING SITE FOR RESIDUE GSP C 395
source : AC6
29) chain C
residue 365
type
sequence C
description BINDING SITE FOR RESIDUE GSP C 395
source : AC6
30) chain C
residue 366
type
sequence A
description BINDING SITE FOR RESIDUE GSP C 395
source : AC6
31) chain C
residue 367
type
sequence V
description BINDING SITE FOR RESIDUE GSP C 395
source : AC6
32) chain A
residue 443
type
sequence Y
description BINDING SITE FOR RESIDUE FOK A 1001
source : AC7
33) chain A
residue 506
type
sequence V
description BINDING SITE FOR RESIDUE FOK A 1001
source : AC7
34) chain A
residue 507
type
sequence W
description BINDING SITE FOR RESIDUE FOK A 1001
source : AC7
35) chain A
residue 508
type
sequence S
description BINDING SITE FOR RESIDUE FOK A 1001
source : AC7
36) chain A
residue 511
type
sequence V
description BINDING SITE FOR RESIDUE FOK A 1001
source : AC7
37) chain A
residue 512
type
sequence T
description BINDING SITE FOR RESIDUE FOK A 1001
source : AC7
38) chain A
residue 515
type
sequence N
description BINDING SITE FOR RESIDUE FOK A 1001
source : AC7
39) chain B
residue 895
type
sequence F
description BINDING SITE FOR RESIDUE FOK A 1001
source : AC7
40) chain B
residue 899
type
sequence Y
description BINDING SITE FOR RESIDUE FOK A 1001
source : AC7
41) chain B
residue 940
type
sequence I
description BINDING SITE FOR RESIDUE FOK A 1001
source : AC7
42) chain B
residue 941
type
sequence G
description BINDING SITE FOR RESIDUE FOK A 1001
source : AC7
43) chain B
residue 942
type
sequence S
description BINDING SITE FOR RESIDUE FOK A 1001
source : AC7
44) chain A
residue 401
type
sequence T
description BINDING SITE FOR RESIDUE 103 B 1082
source : AC8
45) chain A
residue 438
type
sequence L
description BINDING SITE FOR RESIDUE 103 B 1082
source : AC8
46) chain A
residue 439
type
sequence G
description BINDING SITE FOR RESIDUE 103 B 1082
source : AC8
47) chain A
residue 440
type
sequence D
description BINDING SITE FOR RESIDUE 103 B 1082
source : AC8
48) chain B
residue 938
type
sequence K
description BINDING SITE FOR RESIDUE 103 B 1082
source : AC8
49) chain B
residue 1018
type
sequence D
description BINDING SITE FOR RESIDUE 103 B 1082
source : AC8
50) chain B
residue 1019
type
sequence I
description BINDING SITE FOR RESIDUE 103 B 1082
source : AC8
51) chain B
residue 1025
type
sequence N
description BINDING SITE FOR RESIDUE 103 B 1082
source : AC8
52) chain B
residue 1028
type
sequence S
description BINDING SITE FOR RESIDUE 103 B 1082
source : AC8
53) chain B
residue 1029
type
sequence R
description BINDING SITE FOR RESIDUE 103 B 1082
source : AC8
54) chain A
residue 396
type
sequence D
description BINDING SITE FOR RESIDUE 3PO A 1003
source : AC9
55) chain A
residue 397
type
sequence I
description BINDING SITE FOR RESIDUE 3PO A 1003
source : AC9
56) chain A
residue 399
type
sequence G
description BINDING SITE FOR RESIDUE 3PO A 1003
source : AC9
57) chain A
residue 400
type
sequence F
description BINDING SITE FOR RESIDUE 3PO A 1003
source : AC9
58) chain A
residue 401
type
sequence T
description BINDING SITE FOR RESIDUE 3PO A 1003
source : AC9
59) chain A
residue 440
type
sequence D
description BINDING SITE FOR RESIDUE 3PO A 1003
source : AC9
60) chain A
residue 484
type
sequence R
description BINDING SITE FOR RESIDUE 3PO A 1003
source : AC9
61) chain B
residue 1029
type
sequence R
description BINDING SITE FOR RESIDUE 3PO A 1003
source : AC9
62) chain B
residue 1065
type
sequence K
description BINDING SITE FOR RESIDUE 3PO A 1003
source : AC9
63) chain A
residue 553
type
sequence Y
description BINDING SITE FOR RESIDUE MES A 1004
source : BC1
64) chain A
residue 556
type
sequence E
description BINDING SITE FOR RESIDUE MES A 1004
source : BC1
65) chain B
residue 1067
type
sequence K
description BINDING SITE FOR RESIDUE MES A 1004
source : BC1
66) chain B
residue 1069
type
sequence D
description BINDING SITE FOR RESIDUE MES A 1004
source : BC1
67) chain B
residue 1038
type
sequence K
description BINDING SITE FOR RESIDUE MES B 1083
source : BC2
68) chain B
residue 1038
type
sequence K
description BINDING SITE FOR RESIDUE MES B 1083
source : BC2
69) chain B
residue 1074
type
sequence F
description BINDING SITE FOR RESIDUE MES B 1083
source : BC2
70) chain B
residue 1075
type
sequence V
description BINDING SITE FOR RESIDUE MES B 1083
source : BC2
71) chain B
residue 1076
type
sequence N
description BINDING SITE FOR RESIDUE MES B 1083
source : BC2
72) chain C
residue 47
type BINDING
sequence G
description BINDING => ECO:0000305|PubMed:10427002, ECO:0000305|PubMed:11087399, ECO:0000305|PubMed:15591060, ECO:0000305|PubMed:16766715, ECO:0000305|PubMed:19243146, ECO:0000305|PubMed:9395396, ECO:0000305|PubMed:9417641
source Swiss-Prot : SWS_FT_FI1
73) chain C
residue 211
type BINDING
sequence K
description BINDING => ECO:0000305|PubMed:10427002, ECO:0000305|PubMed:11087399, ECO:0000305|PubMed:15591060, ECO:0000305|PubMed:16766715, ECO:0000305|PubMed:19243146, ECO:0000305|PubMed:9395396, ECO:0000305|PubMed:9417641
source Swiss-Prot : SWS_FT_FI1
74) chain C
residue 237
type BINDING
sequence C
description BINDING => ECO:0000305|PubMed:10427002, ECO:0000305|PubMed:11087399, ECO:0000305|PubMed:15591060, ECO:0000305|PubMed:16766715, ECO:0000305|PubMed:19243146, ECO:0000305|PubMed:9395396, ECO:0000305|PubMed:9417641
source Swiss-Prot : SWS_FT_FI1
75) chain C
residue 306
type BINDING
sequence S
description BINDING => ECO:0000305|PubMed:10427002, ECO:0000305|PubMed:11087399, ECO:0000305|PubMed:15591060, ECO:0000305|PubMed:16766715, ECO:0000305|PubMed:19243146, ECO:0000305|PubMed:9395396, ECO:0000305|PubMed:9417641
source Swiss-Prot : SWS_FT_FI1
76) chain C
residue 380
type BINDING
sequence R
description BINDING => ECO:0000305|PubMed:10427002, ECO:0000305|PubMed:11087399, ECO:0000305|PubMed:15591060, ECO:0000305|PubMed:16766715, ECO:0000305|PubMed:19243146, ECO:0000305|PubMed:9395396, ECO:0000305|PubMed:9417641
source Swiss-Prot : SWS_FT_FI1
77) chain C
residue 54
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:10427002, ECO:0000269|PubMed:11087399, ECO:0000269|PubMed:15591060, ECO:0000269|PubMed:19243146, ECO:0000269|PubMed:9395396, ECO:0000269|PubMed:9417641, ECO:0000305|PubMed:16766715
source Swiss-Prot : SWS_FT_FI2
78) chain C
residue 218
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:10427002, ECO:0000269|PubMed:11087399, ECO:0000269|PubMed:15591060, ECO:0000269|PubMed:19243146, ECO:0000269|PubMed:9395396, ECO:0000269|PubMed:9417641, ECO:0000305|PubMed:16766715
source Swiss-Prot : SWS_FT_FI2
79) chain A
residue 521
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:10427002, ECO:0000269|PubMed:11087399, ECO:0000269|PubMed:15591060, ECO:0000269|PubMed:19243146, ECO:0000269|PubMed:9395396, ECO:0000269|PubMed:9417641, ECO:0000305|PubMed:16766715
source Swiss-Prot : SWS_FT_FI2
80) chain B
residue 1029
type catalytic
sequence R
description 58
source MCSA : MCSA1
81) chain B
residue 1065
type catalytic
sequence K
description 58
source MCSA : MCSA1
82) chain A
residue 521
type catalytic
sequence G
description 58
source MCSA : MCSA1
83) chain C
residue 366
type MOD_RES
sequence A
description Phosphoserine => ECO:0000250|UniProtKB:P63092
source Swiss-Prot : SWS_FT_FI3
84) chain A
residue 565
type MOD_RES
sequence L
description Phosphoserine => ECO:0000250|UniProtKB:P63092
source Swiss-Prot : SWS_FT_FI3
85) chain C
residue 314
type CROSSLNK
sequence E
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P63092
source Swiss-Prot : SWS_FT_FI6
86) chain A
residue 495-518
type prosite
sequence GVLGLRKWQFDVWSNDVTLANHME
description GUANYLATE_CYCLASE_1 Guanylate cyclase signature. GVL.GlrkwqFdVWSNDVTlanhmE
source prosite : PS00452
87) chain B
residue 1008-1031
type prosite
sequence GVIGAQKPQYDIWGNTVNVASRMD
description GUANYLATE_CYCLASE_1 Guanylate cyclase signature. GVL.GlrkwqFdVWSNDVTlanhmE
source prosite : PS00452

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