eF-site ID 1crl-A PDB Code 1crl Chain A click to enlarge Title INSIGHTS INTO INTERFACIAL ACTIVATION FROM AN 'OPEN' STRUCTURE OF CANDIDA RUGOSA LIPASE Classification HYDROLASE(CARBOXYLIC ESTERASE) Compound LIPASE Source Candida rugosa (Yeast) (Candida cylindracea) (LIP1_CANRU) Sequence A:  APTATLANGDTITGLNAIINEAFLGIPFAEPPVGNLRFKD PVPYSGSLDGQKFTSYGPSCMQQNPEGTYEENLPKAALDL VMQSKVFEAVSPSSEDCLTINVVRPPGTKAGANLPVMLWI FGGGFEVGGTSTFPPAQMITKSIAMGKPIIHVSVNYRVSS WGFLAGDEIKAEGSANAGLKDQRLGMQWVADNIAAFGGDP TKVTIFGESAGSMSVMCHILWNDGDNTYKGKPLFRAGIMQ SGAMVPSDAVDGIYGNEIFDLLASNAGCGSASDKLACLRG VSSDTLEDATNNTPGFLAYSSLRLSYLPRPDGVNITDDMY ALVREGKYANIPVIIGDQNDEGTFFGTSSLNVTTDAQARE YFKQSFVHASDAEIDTLMTAYPGDITQGSPFDTGILNALT PQFKRISAVLGDLGFTLARRYFLNHYTGGTKYSFLSKQLS GLPVLGTFHSNDIVFQDYLLGSGSLIYNNAFIAFATDLDP NTAGLLVKWPEYTSSSQSGNNLMMINALGLYTGKDNFRTA GYDALFSNPPSFFV Description (1)  LIPASE (E.C.3.1.1.3) (TRIACYLGLYCEROL HYDROLASE) Functional site 1) chain A residue 209 type sequence S description source : ACT 2) chain A residue 341 type sequence E description source : ACT 3) chain A residue 449 type sequence H description source : ACT 4) chain A residue 196-211 type prosite sequence FGGDPTKVTIFGESAG description CARBOXYLESTERASE_B_1 Carboxylesterases type-B serine active site. FGGdptkVtIfGeSAG source prosite : PS00122 5) chain A residue 95-105 type prosite sequence EDCLTINVVRP description CARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLTINVVrP source prosite : PS00941 6) chain A residue 209 type ACT_SITE sequence S description Acyl-ester intermediate source Swiss-Prot : SWS_FT_FI1 7) chain A residue 341 type ACT_SITE sequence E description Charge relay system source Swiss-Prot : SWS_FT_FI2 8) chain A residue 449 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI2 9) chain A residue 314 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine source Swiss-Prot : SWS_FT_FI3 10) chain A residue 351 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine source Swiss-Prot : SWS_FT_FI3

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