eF-site ID 1cqq-A PDB Code 1cqq Chain A click to enlarge Title TYPE 2 RHINOVIRUS 3C PROTEASE WITH AG7088 INHIBITOR Classification HYDROLASE Compound TYPE 2 RHINOVIRUS 3C PROTEASE Source ORGANISM_SCIENTIFIC: Human rhinovirus 2; Sequence A:  GPEEEFGMSLIKHNSCVITTENGKFTGLGVYDRFVVVPTH ADPGKEIQVDGITTKVIDSYDLYNKNGIKLEITVLKLDRN EKFRDIRRYIPNNEDDYPNCNLALLANQPEPTIINVGDVV SYGNILLSGNQTARMLKYSYPTKSGYCGGVLYKIGQVLGI HVGGNGRDGFSAMLLRSYFT Description (1)  TYPE 2 RHINOVIRUS 3C PROTEASE Functional site 1) chain A residue 2 type sequence P description BINDING SITE FOR RESIDUE AG7 A 501 source : AC1 2) chain A residue 22 type sequence N description BINDING SITE FOR RESIDUE AG7 A 501 source : AC1 3) chain A residue 24 type sequence K description BINDING SITE FOR RESIDUE AG7 A 501 source : AC1 4) chain A residue 25 type sequence F description BINDING SITE FOR RESIDUE AG7 A 501 source : AC1 5) chain A residue 40 type sequence H description BINDING SITE FOR RESIDUE AG7 A 501 source : AC1 6) chain A residue 71 type sequence E description BINDING SITE FOR RESIDUE AG7 A 501 source : AC1 7) chain A residue 126 type sequence L description BINDING SITE FOR RESIDUE AG7 A 501 source : AC1 8) chain A residue 127 type sequence L description BINDING SITE FOR RESIDUE AG7 A 501 source : AC1 9) chain A residue 128 type sequence S description BINDING SITE FOR RESIDUE AG7 A 501 source : AC1 10) chain A residue 130 type sequence N description BINDING SITE FOR RESIDUE AG7 A 501 source : AC1 11) chain A residue 142 type sequence T description BINDING SITE FOR RESIDUE AG7 A 501 source : AC1 12) chain A residue 143 type sequence K description BINDING SITE FOR RESIDUE AG7 A 501 source : AC1 13) chain A residue 145 type sequence G description BINDING SITE FOR RESIDUE AG7 A 501 source : AC1 14) chain A residue 146 type sequence Y description BINDING SITE FOR RESIDUE AG7 A 501 source : AC1 15) chain A residue 147 type sequence C description BINDING SITE FOR RESIDUE AG7 A 501 source : AC1 16) chain A residue 161 type sequence H description BINDING SITE FOR RESIDUE AG7 A 501 source : AC1 17) chain A residue 162 type sequence V description BINDING SITE FOR RESIDUE AG7 A 501 source : AC1 18) chain A residue 163 type sequence G description BINDING SITE FOR RESIDUE AG7 A 501 source : AC1 19) chain A residue 164 type sequence G description BINDING SITE FOR RESIDUE AG7 A 501 source : AC1 20) chain A residue 165 type sequence N description BINDING SITE FOR RESIDUE AG7 A 501 source : AC1 21) chain A residue 170 type sequence F description BINDING SITE FOR RESIDUE AG7 A 501 source : AC1 22) chain A residue 40 type ACT_SITE sequence H description For protease 3C activity => ECO:0000255|PROSITE-ProRule:PRU01222 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 71 type ACT_SITE sequence E description For protease 3C activity => ECO:0000255|PROSITE-ProRule:PRU01222 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 147 type ACT_SITE sequence C description For protease 3C activity => ECO:0000255|PROSITE-ProRule:PRU01222 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 40 type catalytic sequence H description 477 source MCSA : MCSA1 26) chain A residue 71 type catalytic sequence E description 477 source MCSA : MCSA1 27) chain A residue 145 type catalytic sequence G description 477 source MCSA : MCSA1 28) chain A residue 147 type catalytic sequence C description 477 source MCSA : MCSA1

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