eF-site ID 1cqi-ABDE PDB Code 1cqi Chain A, B, D, E click to enlarge Title Crystal Structure of the Complex of ADP and MG2+ with Dephosphorylated E. Coli Succinyl-CoA Synthetase Classification LIGASE Compound PROTEIN (SUCCINYL-COA SYNTHETASE ALPHA CHAIN) Source (SUCC_ECOLI) Sequence A:  SILIDKNTKVICQGFTGSQGTFHSEQAIAYGTKMVGGVTP GKGGTTHLGLPVFNTVREAVAATGATASVIYVPAPFCKDS ILEAIDAGIKLIITITEGIPTLDMLTVKVKLDEAGVRMIG PNCPGVITPGECKIGIQPGHIHKPGKVGIVSRSGTLTYEA VKQTTDYGFGQSTCVGIGGDPIPGSNFIDILEMFEKDPQT EAIVMIGEIGGSAEEEAAAYIKEHVTKPVVGYIAGVTAPK GKRMGHAGAIIAGGKGTADEKFAALEAAGVKTVRSLADIG EALKTV B:  MNLHEYQAKQLFARYGLPAPVGYACTTPREAEEAASKIGA GPWVVKCQVHAGGRGKAGGVKVVNSKEDIRAFAENWLGKR LVTYQTDANGQPVNQILVEAATDIAKELYLGAVVDRSSRR VVFMASTEGGVEIEKVAEETPHLIHKVALDPLTGPMPYQG RELAFKLGLEGKLVQQFTKIFMGLATIFLERDLALIEINP LVITKQGDLICLDGKLGADGNALFRQPDLREMRDQSQEDP REAQAAQWELNYVALDGNIGCMVNGAGLAMGTMDIVKLHG GEPANFLDVGGGATKERVTEAFKIILSDDKVKAVLVNIFG GIVRCDLIADGIIGAVAEVGVNVPVVVRLEGNNAELGAKK LADSGLNIIAAKGLTDAAQQVVAAV D:  SILIDKNTKVICQGFTGSQGTFHSEQAIAYGTKMVGGVTP GKGGTTHLGLPVFNTVREAVAATGATASVIYVPAPFCKDS ILEAIDAGIKLIITITEGIPTLDMLTVKVKLDEAGVRMIG PNCPGVITPGECKIGIQPGHIHKPGKVGIVSRSGTLTYEA VKQTTDYGFGQSTCVGIGGDPIPGSNFIDILEMFEKDPQT EAIVMIGEIGGSAEEEAAAYIKEHVTKPVVGYIAGVTAPK GKRMGHAGAIIAGGKGTADEKFAALEAAGVKTVRSLADIG EALKTV E:  MNLHEYQAKQLFARYGLPAPVGYACTTPREAEEAASKIGA GPWVVKCQVHAGGRGKAGGVKVVNSKEDIRAFAENWLGKR LVTYQTDANGQPVNQILVEAATDIAKELYLGAVVDRSSRR VVFMASTEGGVEIEKVAEETPHLIHKVALDPLTGPMPYQG RELAFKLGLEGKLVQQFTKIFMGLATIFLERDLALIEINP LVITKQGDLICLDGKLGADGNALFRQPDLREMRDQSQEDP REAQAAQWELNYVALDGNIGCMVNGAGLAMGTMDIVKLHG GEPANFLDVGGGATKERVTEAFKIILSDDKVKAVLVNIFG GIVRCDLIADGIIGAVAEVGVNVPVVVRLEGNNAELGAKK LADSGLNIIAAKGLTDAAQQVVAAV Description (1)  SUCCINYL-COA SYNTHETASE ALPHA AND BETA SUBUNITS (E.C.6.2.1.5) Functional site 1) chain B residue 199 type sequence N description BINDING SITE FOR RESIDUE MG B 501 source : AC1 2) chain B residue 213 type sequence D description BINDING SITE FOR RESIDUE MG B 501 source : AC1 3) chain E residue 199 type sequence N description BINDING SITE FOR RESIDUE MG E 502 source : AC2 4) chain E residue 213 type sequence D description BINDING SITE FOR RESIDUE MG E 502 source : AC2 5) chain A residue 153 type sequence S description BINDING SITE FOR RESIDUE PO4 A 601 source : AC3 6) chain A residue 154 type sequence G description BINDING SITE FOR RESIDUE PO4 A 601 source : AC3 7) chain A residue 155 type sequence T description BINDING SITE FOR RESIDUE PO4 A 601 source : AC3 8) chain A residue 246 type sequence H description BINDING SITE FOR RESIDUE PO4 A 601 source : AC3 9) chain B residue 265 type sequence G description BINDING SITE FOR RESIDUE PO4 A 601 source : AC3 10) chain B residue 266 type sequence A description BINDING SITE FOR RESIDUE PO4 A 601 source : AC3 11) chain B residue 267 type sequence G description BINDING SITE FOR RESIDUE PO4 A 601 source : AC3 12) chain D residue 153 type sequence S description BINDING SITE FOR RESIDUE PO4 D 602 source : AC4 13) chain D residue 154 type sequence G description BINDING SITE FOR RESIDUE PO4 D 602 source : AC4 14) chain D residue 155 type sequence T description BINDING SITE FOR RESIDUE PO4 D 602 source : AC4 15) chain D residue 246 type sequence H description BINDING SITE FOR RESIDUE PO4 D 602 source : AC4 16) chain E residue 265 type sequence G description BINDING SITE FOR RESIDUE PO4 D 602 source : AC4 17) chain E residue 266 type sequence A description BINDING SITE FOR RESIDUE PO4 D 602 source : AC4 18) chain E residue 267 type sequence G description BINDING SITE FOR RESIDUE PO4 D 602 source : AC4 19) chain A residue 14 type sequence G description BINDING SITE FOR RESIDUE COA A 701 source : AC5 20) chain A residue 16 type sequence T description BINDING SITE FOR RESIDUE COA A 701 source : AC5 21) chain A residue 17 type sequence G description BINDING SITE FOR RESIDUE COA A 701 source : AC5 22) chain A residue 18 type sequence S description BINDING SITE FOR RESIDUE COA A 701 source : AC5 23) chain A residue 19 type sequence Q description BINDING SITE FOR RESIDUE COA A 701 source : AC5 24) chain A residue 40 type sequence P description BINDING SITE FOR RESIDUE COA A 701 source : AC5 25) chain A residue 42 type sequence K description BINDING SITE FOR RESIDUE COA A 701 source : AC5 26) chain A residue 71 type sequence Y description BINDING SITE FOR RESIDUE COA A 701 source : AC5 27) chain A residue 72 type sequence V description BINDING SITE FOR RESIDUE COA A 701 source : AC5 28) chain A residue 73 type sequence P description BINDING SITE FOR RESIDUE COA A 701 source : AC5 29) chain A residue 95 type sequence I description BINDING SITE FOR RESIDUE COA A 701 source : AC5 30) chain A residue 96 type sequence T description BINDING SITE FOR RESIDUE COA A 701 source : AC5 31) chain A residue 97 type sequence E description BINDING SITE FOR RESIDUE COA A 701 source : AC5 32) chain A residue 123 type sequence C description BINDING SITE FOR RESIDUE COA A 701 source : AC5 33) chain A residue 136 type sequence I description BINDING SITE FOR RESIDUE COA A 701 source : AC5 34) chain B residue 161 type sequence R description BINDING SITE FOR RESIDUE COA A 701 source : AC5 35) chain E residue 29 type sequence R description BINDING SITE FOR RESIDUE COA A 701 source : AC5 36) chain E residue 33 type sequence E description BINDING SITE FOR RESIDUE COA A 701 source : AC5 37) chain E residue 36 type sequence S description BINDING SITE FOR RESIDUE COA A 701 source : AC5 38) chain E residue 66 type sequence K description BINDING SITE FOR RESIDUE COA A 701 source : AC5 39) chain B residue 29 type sequence R description BINDING SITE FOR RESIDUE COA D 702 source : AC6 40) chain B residue 33 type sequence E description BINDING SITE FOR RESIDUE COA D 702 source : AC6 41) chain B residue 36 type sequence S description BINDING SITE FOR RESIDUE COA D 702 source : AC6 42) chain B residue 66 type sequence K description BINDING SITE FOR RESIDUE COA D 702 source : AC6 43) chain D residue 14 type sequence G description BINDING SITE FOR RESIDUE COA D 702 source : AC6 44) chain D residue 16 type sequence T description BINDING SITE FOR RESIDUE COA D 702 source : AC6 45) chain D residue 17 type sequence G description BINDING SITE FOR RESIDUE COA D 702 source : AC6 46) chain D residue 18 type sequence S description BINDING SITE FOR RESIDUE COA D 702 source : AC6 47) chain D residue 19 type sequence Q description BINDING SITE FOR RESIDUE COA D 702 source : AC6 48) chain D residue 40 type sequence P description BINDING SITE FOR RESIDUE COA D 702 source : AC6 49) chain D residue 42 type sequence K description BINDING SITE FOR RESIDUE COA D 702 source : AC6 50) chain D residue 71 type sequence Y description BINDING SITE FOR RESIDUE COA D 702 source : AC6 51) chain D residue 72 type sequence V description BINDING SITE FOR RESIDUE COA D 702 source : AC6 52) chain D residue 73 type sequence P description BINDING SITE FOR RESIDUE COA D 702 source : AC6 53) chain D residue 95 type sequence I description BINDING SITE FOR RESIDUE COA D 702 source : AC6 54) chain D residue 96 type sequence T description BINDING SITE FOR RESIDUE COA D 702 source : AC6 55) chain D residue 97 type sequence E description BINDING SITE FOR RESIDUE COA D 702 source : AC6 56) chain D residue 123 type sequence C description BINDING SITE FOR RESIDUE COA D 702 source : AC6 57) chain D residue 136 type sequence I description BINDING SITE FOR RESIDUE COA D 702 source : AC6 58) chain B residue 44 type sequence V description BINDING SITE FOR RESIDUE ADP B 801 source : AC7 59) chain B residue 46 type sequence K description BINDING SITE FOR RESIDUE ADP B 801 source : AC7 60) chain B residue 53 type sequence G description BINDING SITE FOR RESIDUE ADP B 801 source : AC7 61) chain B residue 54 type sequence R description BINDING SITE FOR RESIDUE ADP B 801 source : AC7 62) chain B residue 55 type sequence G description BINDING SITE FOR RESIDUE ADP B 801 source : AC7 63) chain B residue 99 type sequence E description BINDING SITE FOR RESIDUE ADP B 801 source : AC7 64) chain B residue 100 type sequence A description BINDING SITE FOR RESIDUE ADP B 801 source : AC7 65) chain B residue 101 type sequence A description BINDING SITE FOR RESIDUE ADP B 801 source : AC7 66) chain B residue 102 type sequence T description BINDING SITE FOR RESIDUE ADP B 801 source : AC7 67) chain B residue 107 type sequence E description BINDING SITE FOR RESIDUE ADP B 801 source : AC7 68) chain B residue 199 type sequence N description BINDING SITE FOR RESIDUE ADP B 801 source : AC7 69) chain B residue 200 type sequence P description BINDING SITE FOR RESIDUE ADP B 801 source : AC7 70) chain B residue 212 type sequence L description BINDING SITE FOR RESIDUE ADP B 801 source : AC7 71) chain B residue 213 type sequence D description BINDING SITE FOR RESIDUE ADP B 801 source : AC7 72) chain E residue 44 type sequence V description BINDING SITE FOR RESIDUE ADP E 802 source : AC8 73) chain E residue 46 type sequence K description BINDING SITE FOR RESIDUE ADP E 802 source : AC8 74) chain E residue 53 type sequence G description BINDING SITE FOR RESIDUE ADP E 802 source : AC8 75) chain E residue 54 type sequence R description BINDING SITE FOR RESIDUE ADP E 802 source : AC8 76) chain E residue 55 type sequence G description BINDING SITE FOR RESIDUE ADP E 802 source : AC8 77) chain E residue 99 type sequence E description BINDING SITE FOR RESIDUE ADP E 802 source : AC8 78) chain E residue 100 type sequence A description BINDING SITE FOR RESIDUE ADP E 802 source : AC8 79) chain E residue 101 type sequence A description BINDING SITE FOR RESIDUE ADP E 802 source : AC8 80) chain E residue 102 type sequence T description BINDING SITE FOR RESIDUE ADP E 802 source : AC8 81) chain E residue 107 type sequence E description BINDING SITE FOR RESIDUE ADP E 802 source : AC8 82) chain E residue 199 type sequence N description BINDING SITE FOR RESIDUE ADP E 802 source : AC8 83) chain E residue 200 type sequence P description BINDING SITE FOR RESIDUE ADP E 802 source : AC8 84) chain E residue 212 type sequence L description BINDING SITE FOR RESIDUE ADP E 802 source : AC8 85) chain E residue 213 type sequence D description BINDING SITE FOR RESIDUE ADP E 802 source : AC8 86) chain B residue 109 type catalytic sequence Y description 476 source MCSA : MCSA1 87) chain B residue 197 type catalytic sequence E description 476 source MCSA : MCSA1 88) chain E residue 109 type catalytic sequence Y description 476 source MCSA : MCSA2 89) chain E residue 197 type catalytic sequence E description 476 source MCSA : MCSA2 90) chain A residue 235-248 type prosite sequence GVTAPKGKRMGHAG description SUCCINYL_COA_LIG_2 ATP-citrate lyase / succinyl-CoA ligases family active site. GvtApkgk...RMGHAG source prosite : PS00399 91) chain A residue 151-180 type prosite sequence SRSGTLTYEAVKQTTDYGFGQSTCVGIGGD description SUCCINYL_COA_LIG_1 ATP-citrate lyase / succinyl-CoA ligases family signature 1. SRSGTLTyEavkqttdygfGqstcVGIGGD source prosite : PS01216 92) chain B residue 257-282 type prosite sequence GNIGCMVNGAGLAMGTMDIVKLHGGE description SUCCINYL_COA_LIG_3 ATP-citrate lyase / succinyl-CoA ligases family signature 3. GnIgcMvNGAGLAmgtmDiVklhgGE source prosite : PS01217 93) chain B residue 46 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_00558, ECO:0000269|PubMed:10625475 source Swiss-Prot : SWS_FT_FI1 94) chain E residue 99 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_00558, ECO:0000269|PubMed:10625475 source Swiss-Prot : SWS_FT_FI1 95) chain E residue 102 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_00558, ECO:0000269|PubMed:10625475 source Swiss-Prot : SWS_FT_FI1 96) chain E residue 107 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_00558, ECO:0000269|PubMed:10625475 source Swiss-Prot : SWS_FT_FI1 97) chain E residue 199 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00558, ECO:0000269|PubMed:10625475 source Swiss-Prot : SWS_FT_FI1 98) chain E residue 213 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00558, ECO:0000269|PubMed:10625475 source Swiss-Prot : SWS_FT_FI1 99) chain B residue 53 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_00558, ECO:0000269|PubMed:10625475 source Swiss-Prot : SWS_FT_FI1 100) chain B residue 99 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_00558, ECO:0000269|PubMed:10625475 source Swiss-Prot : SWS_FT_FI1 101) chain B residue 102 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_00558, ECO:0000269|PubMed:10625475 source Swiss-Prot : SWS_FT_FI1 102) chain B residue 107 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_00558, ECO:0000269|PubMed:10625475 source Swiss-Prot : SWS_FT_FI1 103) chain B residue 199 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00558, ECO:0000269|PubMed:10625475 source Swiss-Prot : SWS_FT_FI1 104) chain B residue 213 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00558, ECO:0000269|PubMed:10625475 source Swiss-Prot : SWS_FT_FI1 105) chain E residue 46 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_00558, ECO:0000269|PubMed:10625475 source Swiss-Prot : SWS_FT_FI1 106) chain E residue 53 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_00558, ECO:0000269|PubMed:10625475 source Swiss-Prot : SWS_FT_FI1 107) chain B residue 264 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00558 source Swiss-Prot : SWS_FT_FI2 108) chain B residue 321 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_00558 source Swiss-Prot : SWS_FT_FI2 109) chain E residue 264 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00558 source Swiss-Prot : SWS_FT_FI2 110) chain E residue 321 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_00558 source Swiss-Prot : SWS_FT_FI2 111) chain D residue 42 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_00558 source Swiss-Prot : SWS_FT_FI2 112) chain D residue 95 type BINDING sequence I description BINDING => ECO:0000255|HAMAP-Rule:MF_00558 source Swiss-Prot : SWS_FT_FI2 113) chain A residue 158 type BINDING sequence Y description BINDING => ECO:0000255|HAMAP-Rule:MF_01988 source Swiss-Prot : SWS_FT_FI3 114) chain D residue 158 type BINDING sequence Y description BINDING => ECO:0000255|HAMAP-Rule:MF_01988 source Swiss-Prot : SWS_FT_FI3

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