eF-site ID 1cqe-B PDB Code 1cqe Chain B click to enlarge Title PROSTAGLANDIN H2 SYNTHASE-1 COMPLEX WITH FLURBIPROFEN Classification OXIDOREDUCTASE Compound PROTEIN (PROSTAGLANDIN H2 SYNTHASE-1) Source ORGANISM_COMMON: sheep; ORGANISM_SCIENTIFIC: Ovis aries; Sequence B:  APVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCT IPEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRD TLMRLVLTVRSNLIPSPPTYNIAHDYISWESFSNVSYYTR ILPSVPRDCPTPMGTKGKKQLPDAEFLSRRFLLRRKFIPD PQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDL GHIYGDNLERQYQLRLFKDGKLKYQMLNGEVYPPSVEEAP VLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATIWLREHN RVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQ QLSGYFLQLKFDPELLFGAQFQYRNRIAMEFNQLYHWHPL MPDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQP AGRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRF GMKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLE KCHPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKASTF GGEVGFNLVKTATLKKLVCLNTKTCPYVSFHVP Description Functional site 1) chain B residue 120 type sequence R description HYDROPHOBIC CHANNEL RESPONSIBLE FOR CYCLOOGENASE ACTIVITY source : COB 2) chain B residue 355 type sequence Y description HYDROPHOBIC CHANNEL RESPONSIBLE FOR CYCLOOGENASE ACTIVITY source : COB 3) chain B residue 385 type sequence Y description HYDROPHOBIC CHANNEL RESPONSIBLE FOR CYCLOOGENASE ACTIVITY source : COB 4) chain B residue 387 type sequence W description HYDROPHOBIC CHANNEL RESPONSIBLE FOR CYCLOOGENASE ACTIVITY source : COB 5) chain B residue 523 type sequence I description HYDROPHOBIC CHANNEL RESPONSIBLE FOR CYCLOOGENASE ACTIVITY source : COB 6) chain B residue 530 type sequence S description HYDROPHOBIC CHANNEL RESPONSIBLE FOR CYCLOOGENASE ACTIVITY source : COB 7) chain B residue 207 type sequence H description HEME POCKET RESPONSIBLE FOR PEROXIDASE ACTIVITY source : POB 8) chain B residue 388 type sequence H description HEME POCKET RESPONSIBLE FOR PEROXIDASE ACTIVITY source : POB 9) chain B residue 74-82 type TRANSMEM sequence IWTWLRTTL description Helical source Swiss-Prot : SWS_FT_FI1 10) chain B residue 86-92 type TRANSMEM sequence PSFIHFL description Helical source Swiss-Prot : SWS_FT_FI1 11) chain B residue 97-105 type TRANSMEM sequence RWLWDFVNA description Helical source Swiss-Prot : SWS_FT_FI1 12) chain B residue 108-122 type TRANSMEM sequence IRDTLMRLVLTVRSN description Helical source Swiss-Prot : SWS_FT_FI1 13) chain B residue 207 type ACT_SITE sequence H description Proton acceptor source Swiss-Prot : SWS_FT_FI2 14) chain B residue 385 type ACT_SITE sequence Y description For cyclooxygenase activity => ECO:0000269|PubMed:2122967 source Swiss-Prot : SWS_FT_FI3 15) chain B residue 388 type BINDING sequence H description axial binding residue source Swiss-Prot : SWS_FT_FI4 16) chain B residue 104 type SITE sequence N description Not glycosylated => ECO:0000269|PubMed:8349699 source Swiss-Prot : SWS_FT_FI5 17) chain B residue 530 type SITE sequence S description Aspirin-acetylated serine source Swiss-Prot : SWS_FT_FI6 18) chain B residue 68 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:8349699 source Swiss-Prot : SWS_FT_FI7 19) chain B residue 144 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:8349699 source Swiss-Prot : SWS_FT_FI7 20) chain B residue 410 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:8349699 source Swiss-Prot : SWS_FT_FI7

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