eF-site ID 1cqe-A
PDB Code 1cqe
Chain A

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Title PROSTAGLANDIN H2 SYNTHASE-1 COMPLEX WITH FLURBIPROFEN
Classification OXIDOREDUCTASE
Compound PROTEIN (PROSTAGLANDIN H2 SYNTHASE-1)
Source ORGANISM_COMMON: sheep; ORGANISM_SCIENTIFIC: Ovis aries;
Sequence A:  PVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTI
PEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRDT
LMRLVLTVRSNLIPSPPTYNIAHDYISWESFSNVSYYTRI
LPSVPRDCPTPMGTKGKKQLPDAEFLSRRFLLRRKFIPDP
QGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLG
HIYGDNLERQYQLRLFKDGKLKYQMLNGEVYPPSVEEAPV
LMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATIWLREHNR
VCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQ
LSGYFLQLKFDPELLFGAQFQYRNRIAMEFNQLYHWHPLM
PDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQPA
GRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFG
MKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEK
CHPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKASTFG
GEVGFNLVKTATLKKLVCLNTKTCPYVSFHVP
Description


Functional site

1) chain A
residue 120
type
sequence R
description HYDROPHOBIC CHANNEL RESPONSIBLE FOR CYCLOOGENASE ACTIVITY
source : COA

2) chain A
residue 355
type
sequence Y
description HYDROPHOBIC CHANNEL RESPONSIBLE FOR CYCLOOGENASE ACTIVITY
source : COA

3) chain A
residue 385
type
sequence Y
description HYDROPHOBIC CHANNEL RESPONSIBLE FOR CYCLOOGENASE ACTIVITY
source : COA

4) chain A
residue 387
type
sequence W
description HYDROPHOBIC CHANNEL RESPONSIBLE FOR CYCLOOGENASE ACTIVITY
source : COA

5) chain A
residue 523
type
sequence I
description HYDROPHOBIC CHANNEL RESPONSIBLE FOR CYCLOOGENASE ACTIVITY
source : COA

6) chain A
residue 530
type
sequence S
description HYDROPHOBIC CHANNEL RESPONSIBLE FOR CYCLOOGENASE ACTIVITY
source : COA

7) chain A
residue 207
type
sequence H
description HEME POCKET RESPONSIBLE FOR PEROXIDASE ACTIVITY
source : POA

8) chain A
residue 388
type
sequence H
description HEME POCKET RESPONSIBLE FOR PEROXIDASE ACTIVITY
source : POA

9) chain A
residue 74-82
type TRANSMEM
sequence IWTWLRTTL
description Helical
source Swiss-Prot : SWS_FT_FI1

10) chain A
residue 86-92
type TRANSMEM
sequence PSFIHFL
description Helical
source Swiss-Prot : SWS_FT_FI1

11) chain A
residue 97-105
type TRANSMEM
sequence RWLWDFVNA
description Helical
source Swiss-Prot : SWS_FT_FI1

12) chain A
residue 108-122
type TRANSMEM
sequence IRDTLMRLVLTVRSN
description Helical
source Swiss-Prot : SWS_FT_FI1

13) chain A
residue 207
type ACT_SITE
sequence H
description Proton acceptor
source Swiss-Prot : SWS_FT_FI2

14) chain A
residue 385
type ACT_SITE
sequence Y
description For cyclooxygenase activity => ECO:0000269|PubMed:2122967
source Swiss-Prot : SWS_FT_FI3

15) chain A
residue 388
type BINDING
sequence H
description axial binding residue
source Swiss-Prot : SWS_FT_FI4

16) chain A
residue 104
type SITE
sequence N
description Not glycosylated => ECO:0000269|PubMed:8349699
source Swiss-Prot : SWS_FT_FI5

17) chain A
residue 530
type SITE
sequence S
description Aspirin-acetylated serine
source Swiss-Prot : SWS_FT_FI6

18) chain A
residue 68
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:8349699
source Swiss-Prot : SWS_FT_FI7

19) chain A
residue 144
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:8349699
source Swiss-Prot : SWS_FT_FI7

20) chain A
residue 410
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:8349699
source Swiss-Prot : SWS_FT_FI7


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