eF-site ID 1cpi-B PDB Code 1cpi Chain B click to enlarge Title REGIOSELECTIVE STRUCTURAL AND FUNCTIONAL MIMICRY OF PEPTIDES. DESIGN OF HYDROLYTICALLY STABLE CYCLIC PEPTIDOMIMETIC INHIBITORS OF HIV-1 PROTEASE Classification HYDROLASE/HYDROLASE INHIBITOR Compound HIV-1 PROTEASE Source Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) (1CPI) Sequence B:  PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEIXGHKAIGTVLVGPT PVNIIGRNLLTQIGXTLNF Description Functional site 1) chain B residue 14 type sequence R description BINDING SITE FOR RESIDUE SO4 A 503 source : AC2 2) chain B residue 15 type sequence I description BINDING SITE FOR RESIDUE SO4 A 503 source : AC2 3) chain B residue 16 type sequence G description BINDING SITE FOR RESIDUE SO4 A 503 source : AC2 4) chain B residue 17 type sequence G description BINDING SITE FOR RESIDUE SO4 A 503 source : AC2 5) chain B residue 1 type sequence P description BINDING SITE FOR RESIDUE SO4 B 501 source : AC3 6) chain B residue 55 type sequence K description BINDING SITE FOR RESIDUE SO4 B 501 source : AC3 7) chain B residue 8 type sequence R description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 8) chain B residue 23 type sequence L description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 9) chain B residue 25 type sequence D description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 10) chain B residue 27 type sequence G description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 11) chain B residue 28 type sequence A description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 12) chain B residue 29 type sequence D description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 13) chain B residue 47 type sequence I description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 14) chain B residue 48 type sequence G description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 15) chain B residue 49 type sequence G description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 16) chain B residue 82 type sequence V description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 17) chain B residue 84 type sequence I description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 18) chain B residue 78 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 19) chain B residue 78 type MOD_RES sequence G description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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