eF-site ID 1cpi-ABC PDB Code 1cpi Chain A, B, C click to enlarge Title REGIOSELECTIVE STRUCTURAL AND FUNCTIONAL MIMICRY OF PEPTIDES. DESIGN OF HYDROLYTICALLY STABLE CYCLIC PEPTIDOMIMETIC INHIBITORS OF HIV-1 PROTEASE Classification HYDROLASE/HYDROLASE INHIBITOR Compound HIV-1 PROTEASE Source Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) (1CPI) Sequence A:  PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEIXGHKAIGTVLVGPT PVNIIGRNLLTQIGXTLNF B:  PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEIXGHKAIGTVLVGPT PVNIIGRNLLTQIGXTLNF C:  NXPIVX Description Functional site 1) chain A residue 1 type sequence P description BINDING SITE FOR RESIDUE SO4 A 502 source : AC1 2) chain A residue 69 type sequence H description BINDING SITE FOR RESIDUE SO4 A 502 source : AC1 3) chain A residue 14 type sequence R description BINDING SITE FOR RESIDUE SO4 A 503 source : AC2 4) chain B residue 14 type sequence R description BINDING SITE FOR RESIDUE SO4 A 503 source : AC2 5) chain B residue 15 type sequence I description BINDING SITE FOR RESIDUE SO4 A 503 source : AC2 6) chain B residue 16 type sequence G description BINDING SITE FOR RESIDUE SO4 A 503 source : AC2 7) chain B residue 17 type sequence G description BINDING SITE FOR RESIDUE SO4 A 503 source : AC2 8) chain A residue 68 type sequence G description BINDING SITE FOR RESIDUE SO4 B 501 source : AC3 9) chain A residue 69 type sequence H description BINDING SITE FOR RESIDUE SO4 B 501 source : AC3 10) chain A residue 70 type sequence K description BINDING SITE FOR RESIDUE SO4 B 501 source : AC3 11) chain B residue 1 type sequence P description BINDING SITE FOR RESIDUE SO4 B 501 source : AC3 12) chain B residue 55 type sequence K description BINDING SITE FOR RESIDUE SO4 B 501 source : AC3 13) chain A residue 25 type sequence D description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 14) chain A residue 27 type sequence G description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 15) chain A residue 28 type sequence A description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 16) chain A residue 29 type sequence D description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 17) chain A residue 30 type sequence D description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 18) chain A residue 48 type sequence G description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 19) chain A residue 49 type sequence G description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 20) chain A residue 50 type sequence I description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 21) chain A residue 81 type sequence P description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 22) chain B residue 8 type sequence R description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 23) chain B residue 23 type sequence L description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 24) chain B residue 25 type sequence D description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 25) chain B residue 27 type sequence G description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 26) chain B residue 28 type sequence A description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 27) chain B residue 29 type sequence D description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 28) chain B residue 47 type sequence I description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 29) chain B residue 48 type sequence G description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 30) chain B residue 49 type sequence G description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 31) chain B residue 82 type sequence V description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 32) chain B residue 84 type sequence I description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 33) chain A residue 22-33 type prosite sequence ALLDTGADDTVL description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL source prosite : PS00141 34) chain A residue 78 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 35) chain B residue 78 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 36) chain A residue 78 type MOD_RES sequence G description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 37) chain B residue 78 type MOD_RES sequence G description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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