eF-site ID 1cpi-A PDB Code 1cpi Chain A click to enlarge Title REGIOSELECTIVE STRUCTURAL AND FUNCTIONAL MIMICRY OF PEPTIDES. DESIGN OF HYDROLYTICALLY STABLE CYCLIC PEPTIDOMIMETIC INHIBITORS OF HIV-1 PROTEASE Classification HYDROLASE/HYDROLASE INHIBITOR Compound HIV-1 PROTEASE Source Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) (1CPI) Sequence A:  PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEIXGHKAIGTVLVGPT PVNIIGRNLLTQIGXTLNF Description (1)  HIV-1 PROTEASE COMPLEXED WITH A CYCLIC PEPTIDE INHIBITOR, CYCLIC PEPTIDOMIMETIC INHIBITOR, METHYLENE GROUP Functional site 1) chain A residue 1 type sequence P description BINDING SITE FOR RESIDUE SO4 A 502 source : AC1 2) chain A residue 69 type sequence H description BINDING SITE FOR RESIDUE SO4 A 502 source : AC1 3) chain A residue 14 type sequence R description BINDING SITE FOR RESIDUE SO4 A 503 source : AC2 4) chain A residue 68 type sequence G description BINDING SITE FOR RESIDUE SO4 B 501 source : AC3 5) chain A residue 69 type sequence H description BINDING SITE FOR RESIDUE SO4 B 501 source : AC3 6) chain A residue 70 type sequence K description BINDING SITE FOR RESIDUE SO4 B 501 source : AC3 7) chain A residue 25 type sequence D description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 8) chain A residue 27 type sequence G description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 9) chain A residue 28 type sequence A description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 10) chain A residue 29 type sequence D description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 11) chain A residue 30 type sequence D description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 12) chain A residue 48 type sequence G description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 13) chain A residue 49 type sequence G description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 14) chain A residue 50 type sequence I description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 15) chain A residue 81 type sequence P description BINDING SITE FOR CHAIN C OF CYCLIC PEPTIDE INHIBITOR source : AC4 16) chain A residue 78 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 78 type MOD_RES sequence G description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 22-33 type prosite sequence ALLDTGADDTVL description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL source prosite : PS00141

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