eF-site ID 1cm8-B PDB Code 1cm8 Chain B click to enlarge Title PHOSPHORYLATED MAP KINASE P38-GAMMA Classification TRANSFERASE Compound PHOSPHORYLATED MAP KINASE P38-GAMMA Source Homo sapiens (Human) (MK12_HUMAN) Sequence B:  RSGFYRQEVTKTAWEVRAVYRDLQPVAVCSAVDGRTGAKV AIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVF TPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFL VYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFG LARQADSEMXGXVVTRWYRAPEVILNWMRYTQTVDIWSVG CIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRL QSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLV LDAEQRVTAGEALAHPYFESLHQVQKYDDSRTLDEWKRVT YKEVLSFKP Description Functional site 1) chain B residue 1158 type sequence N description BINDING SITE FOR RESIDUE MG B 1401 source : AC3 2) chain B residue 1171 type sequence D description BINDING SITE FOR RESIDUE MG B 1401 source : AC3 3) chain B residue 1171 type sequence D description BINDING SITE FOR RESIDUE MG B 1402 source : AC4 4) chain B residue 1041 type sequence V description BINDING SITE FOR RESIDUE ANP B 1400 source : AC6 5) chain B residue 1054 type sequence A description BINDING SITE FOR RESIDUE ANP B 1400 source : AC6 6) chain B residue 1056 type sequence K description BINDING SITE FOR RESIDUE ANP B 1400 source : AC6 7) chain B residue 1087 type sequence I description BINDING SITE FOR RESIDUE ANP B 1400 source : AC6 8) chain B residue 1109 type sequence M description BINDING SITE FOR RESIDUE ANP B 1400 source : AC6 9) chain B residue 1110 type sequence P description BINDING SITE FOR RESIDUE ANP B 1400 source : AC6 10) chain B residue 1112 type sequence M description BINDING SITE FOR RESIDUE ANP B 1400 source : AC6 11) chain B residue 1115 type sequence D description BINDING SITE FOR RESIDUE ANP B 1400 source : AC6 12) chain B residue 1155 type sequence K description BINDING SITE FOR RESIDUE ANP B 1400 source : AC6 13) chain B residue 1157 type sequence G description BINDING SITE FOR RESIDUE ANP B 1400 source : AC6 14) chain B residue 1158 type sequence N description BINDING SITE FOR RESIDUE ANP B 1400 source : AC6 15) chain B residue 1170 type sequence L description BINDING SITE FOR RESIDUE ANP B 1400 source : AC6 16) chain B residue 1171 type sequence D description BINDING SITE FOR RESIDUE ANP B 1400 source : AC6 17) chain B residue 1153 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI1 18) chain B residue 1033 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 19) chain B residue 1056 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 20) chain B residue 1183 type MOD_RES sequence X description Phosphothreonine; by MAP2K3 and MAP2K6 => ECO:0000250|UniProtKB:Q63538 source Swiss-Prot : SWS_FT_FI3 21) chain B residue 1185 type MOD_RES sequence X description Phosphotyrosine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4

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