eF-site ID 1chg-A PDB Code 1chg Chain A click to enlarge Title CHYMOTRYPSINOGEN,2.5 ANGSTROMS CRYSTAL STRUCTURE, COMPARISON WITH ALPHA-CHYMOTRYPSIN,AND IMPLICATIONS FOR ZYMOGEN ACTIVATION Classification HYDROLASE ZYMOGEN (SERINE PROTEINASE) Compound CHYMOTRYPSINOGEN A Source Bos taurus (Bovine) (CTRA_BOVIN) Sequence A:  CGVPAIQPVLSGLSRIVNGEEAVPGSWPWQVSLQDKTGFH FCGGSLINENWVVTAAHCGVTTSDVVVAGESEKIQKLKIA KVFKNSKYNSLTINNDITLLKLSTAASFSQTVSAVCLPSA SDDFAAGTTCVTTGWGLDRLQQASLPLLSNTNCKKYWGTK IKDAMICAGASGVSSCMGDSGGPLVCKKNGAWTLVGIVSW GSSTCSTSTPGVYARVTALVNWVQQTLAAN Description Functional site 1) chain A residue 57 type catalytic sequence H description 387 source MCSA : MCSA1 2) chain A residue 102 type catalytic sequence D description 387 source MCSA : MCSA1 3) chain A residue 193 type catalytic sequence G description 387 source MCSA : MCSA1 4) chain A residue 195 type catalytic sequence S description 387 source MCSA : MCSA1 5) chain A residue 196 type catalytic sequence G description 387 source MCSA : MCSA1 6) chain A residue 53-58 type prosite sequence VTAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC source prosite : PS00134 7) chain A residue 189-200 type prosite sequence SSCMGDSGGPLV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. SScmGDSGGPLV source prosite : PS00135 8) chain A residue 57 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI1 9) chain A residue 102 type ACT_SITE sequence D description Charge relay system source Swiss-Prot : SWS_FT_FI1 10) chain A residue 195 type ACT_SITE sequence S description Charge relay system source Swiss-Prot : SWS_FT_FI1

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