eF-site ID 1ch4-C
PDB Code 1ch4
Chain C

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Title MODULE-SUBSTITUTED CHIMERA HEMOGLOBIN BETA-ALPHA (F133V)
Classification OXYGEN TRANSPORT
Compound MODULE-SUBSTITUTED CHIMERA HEMOGLOBIN BETA-ALPHA
Source (1CH4)
Sequence C:  VHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQR
FFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDN
LKGTFATLSELHCDKLRVDPVNFKLLSHCLLVTLAAHLPA
EFTPAVHASLDKVLASVSTVLTSKYR
Description


Functional site
1) chain C
residue 41
type
sequence F
description BINDING SITE FOR RESIDUE HEM C 147
source : AC5
2) chain C
residue 42
type
sequence F
description BINDING SITE FOR RESIDUE HEM C 147
source : AC5
3) chain C
residue 63
type
sequence H
description BINDING SITE FOR RESIDUE HEM C 147
source : AC5
4) chain C
residue 92
type
sequence H
description BINDING SITE FOR RESIDUE HEM C 147
source : AC5
5) chain C
residue 96
type
sequence L
description BINDING SITE FOR RESIDUE HEM C 147
source : AC5
6) chain C
residue 98
type
sequence V
description BINDING SITE FOR RESIDUE HEM C 147
source : AC5
7) chain C
residue 102
type
sequence N
description BINDING SITE FOR RESIDUE HEM C 147
source : AC5
8) chain C
residue 103
type
sequence F
description BINDING SITE FOR RESIDUE HEM C 147
source : AC5
9) chain C
residue 106
type
sequence L
description BINDING SITE FOR RESIDUE HEM C 147
source : AC5
10) chain C
residue 141
type
sequence L
description BINDING SITE FOR RESIDUE HEM C 147
source : AC5
11) chain C
residue 63
type
sequence H
description BINDING SITE FOR RESIDUE CMO C 148
source : AC6
12) chain C
residue 67
type
sequence V
description BINDING SITE FOR RESIDUE CMO C 148
source : AC6
13) chain C
residue 2
type BINDING
sequence H
description
source Swiss-Prot : SWS_FT_FI1
14) chain C
residue 82
type BINDING
sequence K
description
source Swiss-Prot : SWS_FT_FI1
15) chain C
residue 143
type BINDING
sequence S
description
source Swiss-Prot : SWS_FT_FI1
16) chain C
residue 1
type BINDING
sequence V
description
source Swiss-Prot : SWS_FT_FI1
17) chain C
residue 93
type MOD_RES
sequence C
description S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411
source Swiss-Prot : SWS_FT_FI10
18) chain C
residue 144
type MOD_RES
sequence K
description N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009
source Swiss-Prot : SWS_FT_FI11
19) chain C
residue 1
type CARBOHYD
sequence V
description N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569
source Swiss-Prot : SWS_FT_FI12
20) chain C
residue 17
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI13
21) chain C
residue 66
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI13
22) chain C
residue 120
type CARBOHYD
sequence A
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI13
23) chain C
residue 8
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI13
24) chain C
residue 144
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI14
25) chain C
residue 63
type BINDING
sequence H
description distal binding residue
source Swiss-Prot : SWS_FT_FI2
26) chain C
residue 92
type BINDING
sequence H
description proximal binding residue
source Swiss-Prot : SWS_FT_FI3
27) chain C
residue 7
type SITE
sequence E
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
28) chain C
residue 25
type SITE
sequence G
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
29) chain C
residue 29
type SITE
sequence G
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
30) chain C
residue 35
type SITE
sequence Y
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
31) chain C
residue 37
type SITE
sequence W
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
32) chain C
residue 45
type SITE
sequence F
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
33) chain C
residue 52
type SITE
sequence D
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
34) chain C
residue 56
type SITE
sequence G
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
35) chain C
residue 71
type SITE
sequence F
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
36) chain C
residue 74
type SITE
sequence G
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
37) chain C
residue 84
type SITE
sequence T
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
38) chain C
residue 92
type SITE
sequence H
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
39) chain C
residue 104
type SITE
sequence K
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
40) chain C
residue 110
type SITE
sequence L
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
41) chain C
residue 119
type SITE
sequence P
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
42) chain C
residue 122
type SITE
sequence F
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
43) chain C
residue 128
type SITE
sequence A
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
44) chain C
residue 140
type SITE
sequence V
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
45) chain C
residue 144
type SITE
sequence K
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
46) chain C
residue 59
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI5
47) chain C
residue 82
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI5
48) chain C
residue 95
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI5
49) chain C
residue 1
type MOD_RES
sequence V
description N-pyruvate 2-iminyl-valine; in Hb A1b
source Swiss-Prot : SWS_FT_FI6
50) chain C
residue 9
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI7
51) chain C
residue 44
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI7
52) chain C
residue 87
type MOD_RES
sequence T
description Phosphothreonine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI8
53) chain C
residue 12
type MOD_RES
sequence T
description Phosphothreonine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI8
54) chain C
residue 50
type MOD_RES
sequence T
description Phosphothreonine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI8
55) chain C
residue 59
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000269|PubMed:4531009
source Swiss-Prot : SWS_FT_FI9
56) chain C
residue 82
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000269|PubMed:4531009
source Swiss-Prot : SWS_FT_FI9

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