eF-site ID 1ch4-B PDB Code 1ch4 Chain B click to enlarge Title MODULE-SUBSTITUTED CHIMERA HEMOGLOBIN BETA-ALPHA (F133V) Classification OXYGEN TRANSPORT Compound MODULE-SUBSTITUTED CHIMERA HEMOGLOBIN BETA-ALPHA Source (1CH4) Sequence B:  VHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQR FFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDN LKGTFATLSELHCDKLRVDPVNFKLLSHCLLVTLAAHLPA EFTPAVHASLDKVLASVSTVLTSKYR Description Functional site 1) chain B residue 41 type sequence F description BINDING SITE FOR RESIDUE HEM B 147 source : AC3 2) chain B residue 42 type sequence F description BINDING SITE FOR RESIDUE HEM B 147 source : AC3 3) chain B residue 45 type sequence F description BINDING SITE FOR RESIDUE HEM B 147 source : AC3 4) chain B residue 63 type sequence H description BINDING SITE FOR RESIDUE HEM B 147 source : AC3 5) chain B residue 92 type sequence H description BINDING SITE FOR RESIDUE HEM B 147 source : AC3 6) chain B residue 96 type sequence L description BINDING SITE FOR RESIDUE HEM B 147 source : AC3 7) chain B residue 98 type sequence V description BINDING SITE FOR RESIDUE HEM B 147 source : AC3 8) chain B residue 102 type sequence N description BINDING SITE FOR RESIDUE HEM B 147 source : AC3 9) chain B residue 103 type sequence F description BINDING SITE FOR RESIDUE HEM B 147 source : AC3 10) chain B residue 106 type sequence L description BINDING SITE FOR RESIDUE HEM B 147 source : AC3 11) chain B residue 63 type sequence H description BINDING SITE FOR RESIDUE CMO B 148 source : AC4 12) chain B residue 67 type sequence V description BINDING SITE FOR RESIDUE CMO B 148 source : AC4 13) chain B residue 1 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI1 14) chain B residue 2 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 15) chain B residue 82 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI1 16) chain B residue 143 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI1 17) chain B residue 93 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411 source Swiss-Prot : SWS_FT_FI10 18) chain B residue 144 type MOD_RES sequence K description N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009 source Swiss-Prot : SWS_FT_FI11 19) chain B residue 1 type CARBOHYD sequence V description N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569 source Swiss-Prot : SWS_FT_FI12 20) chain B residue 8 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI13 21) chain B residue 17 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI13 22) chain B residue 66 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI13 23) chain B residue 120 type CARBOHYD sequence A description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI13 24) chain B residue 144 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI14 25) chain B residue 63 type BINDING sequence H description distal binding residue source Swiss-Prot : SWS_FT_FI2 26) chain B residue 92 type BINDING sequence H description proximal binding residue source Swiss-Prot : SWS_FT_FI3 27) chain B residue 7 type SITE sequence E description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 28) chain B residue 25 type SITE sequence G description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 29) chain B residue 29 type SITE sequence G description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 30) chain B residue 35 type SITE sequence Y description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 31) chain B residue 37 type SITE sequence W description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 32) chain B residue 45 type SITE sequence F description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 33) chain B residue 52 type SITE sequence D description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 34) chain B residue 56 type SITE sequence G description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 35) chain B residue 71 type SITE sequence F description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 36) chain B residue 74 type SITE sequence G description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 37) chain B residue 84 type SITE sequence T description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 38) chain B residue 92 type SITE sequence H description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 39) chain B residue 104 type SITE sequence K description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 40) chain B residue 110 type SITE sequence L description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 41) chain B residue 119 type SITE sequence P description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 42) chain B residue 122 type SITE sequence F description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 43) chain B residue 128 type SITE sequence A description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 44) chain B residue 140 type SITE sequence V description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 45) chain B residue 144 type SITE sequence K description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 46) chain B residue 59 type SITE sequence K description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI5 47) chain B residue 82 type SITE sequence K description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI5 48) chain B residue 95 type SITE sequence K description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI5 49) chain B residue 1 type MOD_RES sequence V description N-pyruvate 2-iminyl-valine; in Hb A1b source Swiss-Prot : SWS_FT_FI6 50) chain B residue 9 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7 51) chain B residue 44 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7 52) chain B residue 12 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI8 53) chain B residue 50 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI8 54) chain B residue 87 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI8 55) chain B residue 59 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:4531009 source Swiss-Prot : SWS_FT_FI9 56) chain B residue 82 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:4531009 source Swiss-Prot : SWS_FT_FI9

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