|
|
eF-site ID
|
1ceh-A |
|
PDB Code
|
1ceh |
|
Chain
|
A |
|
click to enlarge
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Title
|
STRUCTURE AND FUNCTION OF THE CATALYTIC SITE MUTANT ASP99ASN OF PHOSPHOLIPASE A2: ABSENCE OF CONSERVED STRUCTURAL WATER |
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Classification
|
HYDROLASE (CARBOXYLIC ESTER) |
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Compound
|
PHOSPHOLIPASE A2 |
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Source
|
Bos taurus (Bovine) (PA21B_BOVIN) |
|
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Sequence
|
A: |
ALWQFNGMIKCKIPSSEPLLDFNNYGCYCGLGGSGTPVDD
LDRCCQTHDNCYKQAKKLDSCKVLVDNPYTNNYSYSCSNN
EITCSSENNACEAFICNCNRNAAICFSKVPYNKEHKNLDK
KNC
|
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Description
|
(1) |
PHOSPHOLIPASE A2 (PLA2) (E.C.3.1.1.4) MUTANT WITH ASP 99 REPLACED BY ASN (D99N)
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Functional site
|
|
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1)
|
chain |
A |
| residue |
28 |
| type |
|
| sequence |
Y
|
| description |
BINDING SITE FOR RESIDUE CA A 124
|
| source |
: AC1
|
|
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2)
|
chain |
A |
| residue |
30 |
| type |
|
| sequence |
G
|
| description |
BINDING SITE FOR RESIDUE CA A 124
|
| source |
: AC1
|
|
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3)
|
chain |
A |
| residue |
32 |
| type |
|
| sequence |
G
|
| description |
BINDING SITE FOR RESIDUE CA A 124
|
| source |
: AC1
|
|
|
4)
|
chain |
A |
| residue |
49 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE CA A 124
|
| source |
: AC1
|
|
|
5)
|
chain |
A |
| residue |
28 |
| type |
BINDING |
| sequence |
Y
|
| description |
BINDING => ECO:0000269|PubMed:10089353, ECO:0000269|PubMed:7265241, ECO:0000269|PubMed:9115986, ECO:0007744|PDB:1BP2, ECO:0007744|PDB:1KVW, ECO:0007744|PDB:1MKS
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
6)
|
chain |
A |
| residue |
30 |
| type |
BINDING |
| sequence |
G
|
| description |
BINDING => ECO:0000269|PubMed:10089353, ECO:0000269|PubMed:7265241, ECO:0000269|PubMed:9115986, ECO:0007744|PDB:1BP2, ECO:0007744|PDB:1KVW, ECO:0007744|PDB:1MKS
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
7)
|
chain |
A |
| residue |
32 |
| type |
BINDING |
| sequence |
G
|
| description |
BINDING => ECO:0000269|PubMed:10089353, ECO:0000269|PubMed:7265241, ECO:0000269|PubMed:9115986, ECO:0007744|PDB:1BP2, ECO:0007744|PDB:1KVW, ECO:0007744|PDB:1MKS
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
A |
| residue |
49 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10089353, ECO:0000269|PubMed:7265241, ECO:0000269|PubMed:9115986, ECO:0007744|PDB:1BP2, ECO:0007744|PDB:1KVW, ECO:0007744|PDB:1MKS
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
9)
|
chain |
A |
| residue |
48 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
ACT_SITE => ECO:0000269|PubMed:7464926
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
10)
|
chain |
A |
| residue |
99 |
| type |
ACT_SITE |
| sequence |
N
|
| description |
ACT_SITE => ECO:0000269|PubMed:7464926
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
11)
|
chain |
A |
| residue |
44-51 |
| type |
prosite |
| sequence |
CCQTHDNC
|
| description |
PA2_HIS Phospholipase A2 histidine active site. CCQtHDnC
|
| source |
prosite : PS00118
|
|
|
|