eF-site ID 1c8t-B PDB Code 1c8t Chain B click to enlarge Title HUMAN STROMELYSIN-1 (E202Q) CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812 Classification HYDROLASE/HYDROLASE INHIBITOR Compound STROMELYSIN-1 Source Homo sapiens (Human) (MMP3_HUMAN) Sequence B:  FPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWE EVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLA HAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHQIGH SLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSL YGPPPDP Description Functional site 1) chain B residue 201 type sequence H description BINDING SITE FOR RESIDUE ZN B 260 source : AC1 2) chain B residue 205 type sequence H description BINDING SITE FOR RESIDUE ZN B 260 source : AC1 3) chain B residue 211 type sequence H description BINDING SITE FOR RESIDUE ZN B 260 source : AC1 4) chain B residue 151 type sequence H description BINDING SITE FOR RESIDUE ZN B 261 source : AC2 5) chain B residue 153 type sequence D description BINDING SITE FOR RESIDUE ZN B 261 source : AC2 6) chain B residue 166 type sequence H description BINDING SITE FOR RESIDUE ZN B 261 source : AC2 7) chain B residue 179 type sequence H description BINDING SITE FOR RESIDUE ZN B 261 source : AC2 8) chain B residue 158 type sequence D description BINDING SITE FOR RESIDUE CA B 262 source : AC3 9) chain B residue 159 type sequence G description BINDING SITE FOR RESIDUE CA B 262 source : AC3 10) chain B residue 161 type sequence G description BINDING SITE FOR RESIDUE CA B 262 source : AC3 11) chain B residue 163 type sequence V description BINDING SITE FOR RESIDUE CA B 262 source : AC3 12) chain B residue 181 type sequence D description BINDING SITE FOR RESIDUE CA B 262 source : AC3 13) chain B residue 184 type sequence E description BINDING SITE FOR RESIDUE CA B 262 source : AC3 14) chain B residue 141 type sequence D description BINDING SITE FOR RESIDUE CA B 263 source : AC4 15) chain B residue 173 type sequence G description BINDING SITE FOR RESIDUE CA B 263 source : AC4 16) chain B residue 175 type sequence N description BINDING SITE FOR RESIDUE CA B 263 source : AC4 17) chain B residue 177 type sequence D description BINDING SITE FOR RESIDUE CA B 263 source : AC4 18) chain B residue 107 type sequence D description BINDING SITE FOR RESIDUE CA B 264 source : AC5 19) chain B residue 182 type sequence D description BINDING SITE FOR RESIDUE CA B 264 source : AC5 20) chain B residue 184 type sequence E description BINDING SITE FOR RESIDUE CA B 264 source : AC5 21) chain B residue 185 type sequence Q description BINDING SITE FOR RESIDUE CA B 264 source : AC5 22) chain B residue 87 type sequence P description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 23) chain B residue 213 type sequence A description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 24) chain B residue 215 type sequence T description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 25) chain B residue 220 type sequence Y description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 26) chain B residue 162 type sequence N description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 27) chain B residue 164 type sequence L description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 28) chain B residue 198 type sequence V description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 29) chain B residue 201 type sequence H description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 30) chain B residue 202 type sequence Q description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 31) chain B residue 205 type sequence H description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 32) chain B residue 211 type sequence H description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 33) chain B residue 217 type sequence A description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 34) chain B residue 218 type sequence L description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 35) chain B residue 220 type sequence Y description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 36) chain B residue 221 type sequence P description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 37) chain B residue 222 type sequence L description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 38) chain B residue 223 type sequence Y description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 39) chain B residue 224 type sequence H description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 40) chain B residue 201 type catalytic sequence H description 591 source MCSA : MCSA2 41) chain B residue 202 type catalytic sequence Q description 591 source MCSA : MCSA2 42) chain B residue 205 type catalytic sequence H description 591 source MCSA : MCSA2 43) chain B residue 211 type catalytic sequence H description 591 source MCSA : MCSA2 44) chain B residue 202 type ACT_SITE sequence Q description source Swiss-Prot : SWS_FT_FI1 45) chain B residue 107 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 46) chain B residue 141 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 47) chain B residue 151 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 48) chain B residue 153 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 49) chain B residue 158 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 50) chain B residue 159 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 51) chain B residue 161 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 52) chain B residue 163 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 53) chain B residue 166 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 54) chain B residue 173 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 55) chain B residue 175 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 56) chain B residue 177 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 57) chain B residue 179 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 58) chain B residue 181 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 59) chain B residue 182 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 60) chain B residue 184 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 61) chain B residue 201 type BINDING sequence H description BINDING => ECO:0000269|PubMed:8740360 source Swiss-Prot : SWS_FT_FI3 62) chain B residue 205 type BINDING sequence H description BINDING => ECO:0000269|PubMed:8740360 source Swiss-Prot : SWS_FT_FI3 63) chain B residue 211 type BINDING sequence H description BINDING => ECO:0000269|PubMed:8740360 source Swiss-Prot : SWS_FT_FI3

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