eF-site ID 1c8t-AB PDB Code 1c8t Chain A, B click to enlarge Title HUMAN STROMELYSIN-1 (E202Q) CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812 Classification HYDROLASE/HYDROLASE INHIBITOR Compound STROMELYSIN-1 Source Homo sapiens (Human) (MMP3_HUMAN) Sequence A:  FPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWE EVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLA HAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHQIGH SLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSL YGPPPDP B:  FPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWE EVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLA HAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHQIGH SLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSL YGPPPDP Description Functional site 1) chain B residue 201 type sequence H description BINDING SITE FOR RESIDUE ZN B 260 source : AC1 2) chain B residue 205 type sequence H description BINDING SITE FOR RESIDUE ZN B 260 source : AC1 3) chain B residue 211 type sequence H description BINDING SITE FOR RESIDUE ZN B 260 source : AC1 4) chain B residue 151 type sequence H description BINDING SITE FOR RESIDUE ZN B 261 source : AC2 5) chain B residue 153 type sequence D description BINDING SITE FOR RESIDUE ZN B 261 source : AC2 6) chain B residue 166 type sequence H description BINDING SITE FOR RESIDUE ZN B 261 source : AC2 7) chain B residue 179 type sequence H description BINDING SITE FOR RESIDUE ZN B 261 source : AC2 8) chain B residue 158 type sequence D description BINDING SITE FOR RESIDUE CA B 262 source : AC3 9) chain B residue 159 type sequence G description BINDING SITE FOR RESIDUE CA B 262 source : AC3 10) chain B residue 161 type sequence G description BINDING SITE FOR RESIDUE CA B 262 source : AC3 11) chain B residue 163 type sequence V description BINDING SITE FOR RESIDUE CA B 262 source : AC3 12) chain B residue 181 type sequence D description BINDING SITE FOR RESIDUE CA B 262 source : AC3 13) chain B residue 184 type sequence E description BINDING SITE FOR RESIDUE CA B 262 source : AC3 14) chain B residue 141 type sequence D description BINDING SITE FOR RESIDUE CA B 263 source : AC4 15) chain B residue 173 type sequence G description BINDING SITE FOR RESIDUE CA B 263 source : AC4 16) chain B residue 175 type sequence N description BINDING SITE FOR RESIDUE CA B 263 source : AC4 17) chain B residue 177 type sequence D description BINDING SITE FOR RESIDUE CA B 263 source : AC4 18) chain B residue 107 type sequence D description BINDING SITE FOR RESIDUE CA B 264 source : AC5 19) chain B residue 182 type sequence D description BINDING SITE FOR RESIDUE CA B 264 source : AC5 20) chain B residue 184 type sequence E description BINDING SITE FOR RESIDUE CA B 264 source : AC5 21) chain B residue 185 type sequence Q description BINDING SITE FOR RESIDUE CA B 264 source : AC5 22) chain A residue 201 type sequence H description BINDING SITE FOR RESIDUE ZN A 260 source : AC6 23) chain A residue 205 type sequence H description BINDING SITE FOR RESIDUE ZN A 260 source : AC6 24) chain A residue 211 type sequence H description BINDING SITE FOR RESIDUE ZN A 260 source : AC6 25) chain A residue 151 type sequence H description BINDING SITE FOR RESIDUE ZN A 261 source : AC7 26) chain A residue 153 type sequence D description BINDING SITE FOR RESIDUE ZN A 261 source : AC7 27) chain A residue 166 type sequence H description BINDING SITE FOR RESIDUE ZN A 261 source : AC7 28) chain A residue 179 type sequence H description BINDING SITE FOR RESIDUE ZN A 261 source : AC7 29) chain A residue 158 type sequence D description BINDING SITE FOR RESIDUE CA A 262 source : AC8 30) chain A residue 159 type sequence G description BINDING SITE FOR RESIDUE CA A 262 source : AC8 31) chain A residue 161 type sequence G description BINDING SITE FOR RESIDUE CA A 262 source : AC8 32) chain A residue 163 type sequence V description BINDING SITE FOR RESIDUE CA A 262 source : AC8 33) chain A residue 181 type sequence D description BINDING SITE FOR RESIDUE CA A 262 source : AC8 34) chain A residue 184 type sequence E description BINDING SITE FOR RESIDUE CA A 262 source : AC8 35) chain A residue 141 type sequence D description BINDING SITE FOR RESIDUE CA A 263 source : AC9 36) chain A residue 173 type sequence G description BINDING SITE FOR RESIDUE CA A 263 source : AC9 37) chain A residue 175 type sequence N description BINDING SITE FOR RESIDUE CA A 263 source : AC9 38) chain A residue 177 type sequence D description BINDING SITE FOR RESIDUE CA A 263 source : AC9 39) chain A residue 107 type sequence D description BINDING SITE FOR RESIDUE CA A 264 source : BC1 40) chain A residue 182 type sequence D description BINDING SITE FOR RESIDUE CA A 264 source : BC1 41) chain A residue 184 type sequence E description BINDING SITE FOR RESIDUE CA A 264 source : BC1 42) chain A residue 162 type sequence N description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 43) chain A residue 163 type sequence V description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 44) chain A residue 164 type sequence L description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 45) chain A residue 165 type sequence A description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 46) chain A residue 197 type sequence L description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 47) chain A residue 201 type sequence H description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 48) chain A residue 202 type sequence Q description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 49) chain A residue 211 type sequence H description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 50) chain A residue 217 type sequence A description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 51) chain A residue 218 type sequence L description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 52) chain A residue 220 type sequence Y description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 53) chain A residue 221 type sequence P description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 54) chain A residue 222 type sequence L description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 55) chain A residue 223 type sequence Y description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 56) chain A residue 224 type sequence H description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 57) chain B residue 87 type sequence P description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 58) chain B residue 213 type sequence A description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 59) chain B residue 215 type sequence T description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 60) chain B residue 220 type sequence Y description BINDING SITE FOR RESIDUE TR1 A 265 source : BC2 61) chain A residue 87 type sequence P description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 62) chain A residue 215 type sequence T description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 63) chain A residue 216 type sequence E description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 64) chain B residue 162 type sequence N description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 65) chain B residue 164 type sequence L description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 66) chain B residue 198 type sequence V description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 67) chain B residue 201 type sequence H description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 68) chain B residue 202 type sequence Q description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 69) chain B residue 205 type sequence H description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 70) chain B residue 211 type sequence H description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 71) chain B residue 217 type sequence A description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 72) chain B residue 218 type sequence L description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 73) chain B residue 220 type sequence Y description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 74) chain B residue 221 type sequence P description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 75) chain B residue 222 type sequence L description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 76) chain B residue 223 type sequence Y description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 77) chain B residue 224 type sequence H description BINDING SITE FOR RESIDUE TR1 B 265 source : BC3 78) chain A residue 201 type catalytic sequence H description 591 source MCSA : MCSA1 79) chain A residue 202 type catalytic sequence Q description 591 source MCSA : MCSA1 80) chain A residue 205 type catalytic sequence H description 591 source MCSA : MCSA1 81) chain A residue 211 type catalytic sequence H description 591 source MCSA : MCSA1 82) chain B residue 201 type catalytic sequence H description 591 source MCSA : MCSA2 83) chain B residue 202 type catalytic sequence Q description 591 source MCSA : MCSA2 84) chain B residue 205 type catalytic sequence H description 591 source MCSA : MCSA2 85) chain B residue 211 type catalytic sequence H description 591 source MCSA : MCSA2 86) chain A residue 202 type ACT_SITE sequence Q description source Swiss-Prot : SWS_FT_FI1 87) chain B residue 202 type ACT_SITE sequence Q description source Swiss-Prot : SWS_FT_FI1 88) chain A residue 107 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 89) chain A residue 173 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 90) chain A residue 175 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 91) chain A residue 177 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 92) chain A residue 179 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 93) chain A residue 181 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 94) chain A residue 182 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 95) chain A residue 184 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 96) chain B residue 107 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 97) chain B residue 141 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 98) chain B residue 151 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 99) chain A residue 141 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 100) chain B residue 153 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 101) chain B residue 158 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 102) chain B residue 159 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 103) chain B residue 161 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 104) chain B residue 163 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 105) chain B residue 166 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 106) chain B residue 173 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 107) chain B residue 175 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 108) chain B residue 177 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 109) chain B residue 179 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 110) chain A residue 151 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 111) chain B residue 181 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 112) chain B residue 182 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 113) chain B residue 184 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 114) chain A residue 153 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 115) chain A residue 158 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 116) chain A residue 159 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 117) chain A residue 161 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 118) chain A residue 163 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 119) chain A residue 166 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 120) chain A residue 201 type BINDING sequence H description BINDING => ECO:0000269|PubMed:8740360 source Swiss-Prot : SWS_FT_FI3 121) chain A residue 205 type BINDING sequence H description BINDING => ECO:0000269|PubMed:8740360 source Swiss-Prot : SWS_FT_FI3 122) chain A residue 211 type BINDING sequence H description BINDING => ECO:0000269|PubMed:8740360 source Swiss-Prot : SWS_FT_FI3 123) chain B residue 201 type BINDING sequence H description BINDING => ECO:0000269|PubMed:8740360 source Swiss-Prot : SWS_FT_FI3 124) chain B residue 205 type BINDING sequence H description BINDING => ECO:0000269|PubMed:8740360 source Swiss-Prot : SWS_FT_FI3 125) chain B residue 211 type BINDING sequence H description BINDING => ECO:0000269|PubMed:8740360 source Swiss-Prot : SWS_FT_FI3

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