eF-site ID 1c8m-1234 PDB Code 1c8m Chain 1, 2, 3, 4 click to enlarge Title REFINED CRYSTAL STRUCTURE OF HUMAN RHINOVIRUS 16 COMPLEXED WITH VP63843 (PLECONARIL), AN ANTI-PICORNAVIRAL DRUG CURRENTLY IN CLINICAL TRIALS Classification VIRUS Compound HUMAN RHINOVIRUS 16 COAT PROTEIN Source ORGANISM_SCIENTIFIC: Human rhinovirus 16; Sequence 1:  NPVERYVDEVLNEVLVVPNINQSHPTTSNAAPVLDAAETG HTNKIQPEDTIETRYVQSSQTLDEMSVESFLGRSGCIHES VLDIVDNYNDQSFTKWNINLQEMAQIRRKFEMFTYARFDS EITMVPSVAAKDGHIGHIVMQYMYVPPGAPIPTTRDDYAW QSGTNASVFWQHGQPFPRFSLPFLSIASAYYMFYDGYDGD TYKSRYGTVVTNDMGTLCSRIVTSEQLHKVKVVTRIYHKA KHTKAWCPRPPRAVQYSHTHTTNYKLSSEVHNDVAIRPRT NLTTV 2:  SDRIIQITRGDSTITSQDVANAVVGYGVWPHYLTPQDATA IDKPTQPDTSSNRFYTLDSKMWNSTSKGWWWKLPDALKDM GIFGENMFYHFLGRSGYTVHVQCNASKFHQGTLLVVMIPE HQLATVNKGNVNAGYKYTHPGEAGREVGTQVENEKQPSDD NWLNFDGTLLGNLLIFPHQFINLRSNNSATLIVPYVNAVP MDSMVRHNNWSLVIIPVCQLQSNNISNIVPITVSISPMCA EFSGARAKTVVQ 3:  GLPVYVTPGSGQFMTTDDMQSPCALPWYHPTKEIFIPGEV KNLIEMCQVDTLIPINSTQSNIGNVSMYTVTLSPQTKLAE EIFAIKVDIASHPLATTLIGEIASYFTHWTGSLRFSFMFC GTANTTLKVLLAYTPPGIGKPRSRKEAMLGTHVVWDVGLQ STVSLVVPWISASQYRFTTPDTYSSAGYITCWYQTNFVVP PNTPNTAEMLCFVSGCKDFCLRMARDTDLHKQTGPITQ 4:  GAQVSRQSINYFNINYFKDAASSGASRLD Description Functional site 1) chain 1 residue 134 type sequence H description PUTATIVE ZINC BINDING SITE ON ICOSAHEDRAL FIVE-FOLD AXIS. ION LIGANDED BY FIVE SYMMETRY RELATED HISTIDINES (HIS 1 134). EXTERIOR OF SITE SURROUNDED BY A WIDER CIRCLE OF FIVE HISTIDINES (HIS 2 228) source : ION 2) chain 1 residue 228 type sequence H description PUTATIVE ZINC BINDING SITE ON ICOSAHEDRAL FIVE-FOLD AXIS. ION LIGANDED BY FIVE SYMMETRY RELATED HISTIDINES (HIS 1 134). EXTERIOR OF SITE SURROUNDED BY A WIDER CIRCLE OF FIVE HISTIDINES (HIS 2 228) source : ION 3) chain 2 residue 38 type sequence W description RNA OBSERVED INTERACTING WITH THESE RESIDUES ON THE INTERIOR SURFACE OF VIRAL PROTEIN CAPSID. NON-CONSERVATIVE MUTATION OF TRP 2 38 GIVES NON-VIABLE VIRUS. source : RNA 4) chain 3 residue 35 type sequence F description RNA OBSERVED INTERACTING WITH THESE RESIDUES ON THE INTERIOR SURFACE OF VIRAL PROTEIN CAPSID. NON-CONSERVATIVE MUTATION OF TRP 2 38 GIVES NON-VIABLE VIRUS. source : RNA 5) chain 1 residue 179 type sequence F description AN ANTIVIRAL COMPOUND IS FOUND IN A POCKET OF VP1 source : POC 6) chain 1 residue 214 type sequence M description AN ANTIVIRAL COMPOUND IS FOUND IN A POCKET OF VP1 source : POC 7) chain 1 residue 217 type sequence L description AN ANTIVIRAL COMPOUND IS FOUND IN A POCKET OF VP1 source : POC 8) chain 1 residue 134 type sequence H description BINDING SITE FOR RESIDUE ZN 1 6000 source : AC1 9) chain 1 residue 77 type sequence I description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 10) chain 1 residue 98 type sequence I description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 11) chain 1 residue 100 type sequence L description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 12) chain 1 residue 124 type sequence M description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 13) chain 1 residue 142 type sequence Y description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 14) chain 1 residue 143 type sequence M description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 15) chain 1 residue 144 type sequence Y description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 16) chain 1 residue 166 type sequence A description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 17) chain 1 residue 168 type sequence V description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 18) chain 1 residue 179 type sequence F description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 19) chain 1 residue 181 type sequence L description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 20) chain 1 residue 184 type sequence L description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 21) chain 1 residue 190 type sequence Y description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 22) chain 1 residue 212 type sequence N description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 23) chain 1 residue 214 type sequence M description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 24) chain 1 residue 217 type sequence L description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 25) chain 4 residue 2 type LIPID sequence A description N-myristoyl glycine; by host => ECO:0000250|UniProtKB:P03300 source Swiss-Prot : SWS_FT_FI2

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