eF-site ID 1c8m-1 PDB Code 1c8m Chain 1 click to enlarge Title REFINED CRYSTAL STRUCTURE OF HUMAN RHINOVIRUS 16 COMPLEXED WITH VP63843 (PLECONARIL), AN ANTI-PICORNAVIRAL DRUG CURRENTLY IN CLINICAL TRIALS Classification VIRUS Compound HUMAN RHINOVIRUS 16 COAT PROTEIN Source ORGANISM_SCIENTIFIC: Human rhinovirus 16; Sequence 1:  NPVERYVDEVLNEVLVVPNINQSHPTTSNAAPVLDAAETG HTNKIQPEDTIETRYVQSSQTLDEMSVESFLGRSGCIHES VLDIVDNYNDQSFTKWNINLQEMAQIRRKFEMFTYARFDS EITMVPSVAAKDGHIGHIVMQYMYVPPGAPIPTTRDDYAW QSGTNASVFWQHGQPFPRFSLPFLSIASAYYMFYDGYDGD TYKSRYGTVVTNDMGTLCSRIVTSEQLHKVKVVTRIYHKA KHTKAWCPRPPRAVQYSHTHTTNYKLSSEVHNDVAIRPRT NLTTV Description Functional site 1) chain 1 residue 134 type sequence H description PUTATIVE ZINC BINDING SITE ON ICOSAHEDRAL FIVE-FOLD AXIS. ION LIGANDED BY FIVE SYMMETRY RELATED HISTIDINES (HIS 1 134). EXTERIOR OF SITE SURROUNDED BY A WIDER CIRCLE OF FIVE HISTIDINES (HIS 2 228) source : ION 2) chain 1 residue 228 type sequence H description PUTATIVE ZINC BINDING SITE ON ICOSAHEDRAL FIVE-FOLD AXIS. ION LIGANDED BY FIVE SYMMETRY RELATED HISTIDINES (HIS 1 134). EXTERIOR OF SITE SURROUNDED BY A WIDER CIRCLE OF FIVE HISTIDINES (HIS 2 228) source : ION 3) chain 1 residue 179 type sequence F description AN ANTIVIRAL COMPOUND IS FOUND IN A POCKET OF VP1 source : POC 4) chain 1 residue 214 type sequence M description AN ANTIVIRAL COMPOUND IS FOUND IN A POCKET OF VP1 source : POC 5) chain 1 residue 217 type sequence L description AN ANTIVIRAL COMPOUND IS FOUND IN A POCKET OF VP1 source : POC 6) chain 1 residue 134 type sequence H description BINDING SITE FOR RESIDUE ZN 1 6000 source : AC1 7) chain 1 residue 77 type sequence I description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 8) chain 1 residue 98 type sequence I description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 9) chain 1 residue 100 type sequence L description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 10) chain 1 residue 124 type sequence M description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 11) chain 1 residue 142 type sequence Y description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 12) chain 1 residue 143 type sequence M description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 13) chain 1 residue 144 type sequence Y description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 14) chain 1 residue 166 type sequence A description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 15) chain 1 residue 168 type sequence V description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 16) chain 1 residue 179 type sequence F description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 17) chain 1 residue 181 type sequence L description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 18) chain 1 residue 184 type sequence L description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 19) chain 1 residue 190 type sequence Y description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 20) chain 1 residue 212 type sequence N description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 21) chain 1 residue 214 type sequence M description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2 22) chain 1 residue 217 type sequence L description BINDING SITE FOR RESIDUE W11 1 7001 source : AC2

Display surface Download Links