eF-site ID 1c5f-CEGIO PDB Code 1c5f Chain C, E, G, I, O click to enlarge Title CRYSTAL STRUCTURE OF THE CYCLOPHILIN-LIKE DOMAIN FROM BRUGIA MALAYI COMPLEXED WITH CYCLOSPORIN A Classification ISOMERASE/IMMUNOSUPPRESSANT Compound PEPTIDYL-PROLYL CIS-TRANS ISOMERASE 1 Source Brugia malayi (Filarial nematode worm) (NOR00033) Sequence C:  MSKKDRRRVFLDVTIDGNLAGRIVMELYNDIAPRTCNNFL MLCTGMAGTGKISGKPLHYKGSTFHRVIKNFMIQGGDFTK GDGTGGESIYGGMFDDEEFVMKHDEPFVVSMANKGPNTNG SQFFITTTPAPHLNNIHVVFGKVVSGQEVVTKIEYLKTNS KNRPLADVVILNCGELV E:  KDRRRVFLDVTIDGNLAGRIVMELYNDIAPRTCNNFLMLC TGMAGTGKISGKPLHYKGSTFHRVIKNFMIQGGDFTKGDG TGGESIYGGMFDDEEFVMKHDEPFVVSMANKGPNTNGSQF FITTTPAPHLNNIHVVFGKVVSGQEVVTKIEYLKTNSKNR PLADVVILNCGELV G:  RRRVFLDVTIDGNLAGRIVMELYNDIAPRTCNNFLMLCTG MAGTGKISGKPLHYKGSTFHRVIKNFMIQGGDFTKGDGTG GESIYGGMFDDEEFVMKHDEPFVVSMANKGPNTNGSQFFI TTTPAPHLNNIHVVFGKVVSGQEVVTKIEYLKTNSKNRPL ADVVILNCGELV I:  DRRRVFLDVTIDGNLAGRIVMELYNDIAPRTCNNFLMLCT GMAGTGKISGKPLHYKGSTFHRVIKNFMIQGGDFTKGDGT GGESIYGGMFDDEEFVMKHDEPFVVSMANKGPNTNGSQFF ITTTPAPHLNNIHVVFGKVVSGQEVVTKIEYLKTNSKNRP LADVVILNCGELV O:  RRRVFLDVTIDGNLAGRIVMELYNDIAPRTCNNFLMLCTG MAGTGKISGKPLHYKGSTFHRVIKNFMIQGGDFTKGDGTG GESIYGGMFDDEEFVMKHDEPFVVSMANKGPNTNGSQFFI TTTPAPHLNNIHVVFGKVVSGQEVVTKIEYLKTNSKNRPL ADVVILNCGELV Description Functional site 1) chain C residue 66 type sequence R description BINDING SITE FOR CHAIN D OF CYCLOSPORIN A source : AC2 2) chain C residue 71 type sequence F description BINDING SITE FOR CHAIN D OF CYCLOSPORIN A source : AC2 3) chain C residue 74 type sequence Q description BINDING SITE FOR CHAIN D OF CYCLOSPORIN A source : AC2 4) chain C residue 83 type sequence G description BINDING SITE FOR CHAIN D OF CYCLOSPORIN A source : AC2 5) chain C residue 112 type sequence A description BINDING SITE FOR CHAIN D OF CYCLOSPORIN A source : AC2 6) chain C residue 113 type sequence N description BINDING SITE FOR CHAIN D OF CYCLOSPORIN A source : AC2 7) chain C residue 114 type sequence K description BINDING SITE FOR CHAIN D OF CYCLOSPORIN A source : AC2 8) chain C residue 122 type sequence Q description BINDING SITE FOR CHAIN D OF CYCLOSPORIN A source : AC2 9) chain C residue 124 type sequence F description BINDING SITE FOR CHAIN D OF CYCLOSPORIN A source : AC2 10) chain C residue 132 type sequence H description BINDING SITE FOR CHAIN D OF CYCLOSPORIN A source : AC2 11) chain C residue 137 type sequence H description BINDING SITE FOR CHAIN D OF CYCLOSPORIN A source : AC2 12) chain E residue 66 type sequence R description BINDING SITE FOR CHAIN F OF CYCLOSPORIN A source : AC3 13) chain E residue 71 type sequence F description BINDING SITE FOR CHAIN F OF CYCLOSPORIN A source : AC3 14) chain E residue 74 type sequence Q description BINDING SITE FOR CHAIN F OF CYCLOSPORIN A source : AC3 15) chain E residue 83 type sequence G description BINDING SITE FOR CHAIN F OF CYCLOSPORIN A source : AC3 16) chain E residue 112 type sequence A description BINDING SITE FOR CHAIN F OF CYCLOSPORIN A source : AC3 17) chain E residue 113 type sequence N description BINDING SITE FOR CHAIN F OF CYCLOSPORIN A source : AC3 18) chain E residue 114 type sequence K description BINDING SITE FOR CHAIN F OF CYCLOSPORIN A source : AC3 19) chain E residue 122 type sequence Q description BINDING SITE FOR CHAIN F OF CYCLOSPORIN A source : AC3 20) chain E residue 124 type sequence F description BINDING SITE FOR CHAIN F OF CYCLOSPORIN A source : AC3 21) chain E residue 132 type sequence H description BINDING SITE FOR CHAIN F OF CYCLOSPORIN A source : AC3 22) chain E residue 137 type sequence H description BINDING SITE FOR CHAIN F OF CYCLOSPORIN A source : AC3 23) chain E residue 46 type sequence M description BINDING SITE FOR CHAIN H OF CYCLOSPORIN A source : AC4 24) chain E residue 47 type sequence A description BINDING SITE FOR CHAIN H OF CYCLOSPORIN A source : AC4 25) chain E residue 89 type sequence I description BINDING SITE FOR CHAIN H OF CYCLOSPORIN A source : AC4 26) chain G residue 66 type sequence R description BINDING SITE FOR CHAIN H OF CYCLOSPORIN A source : AC4 27) chain G residue 71 type sequence F description BINDING SITE FOR CHAIN H OF CYCLOSPORIN A source : AC4 28) chain G residue 74 type sequence Q description BINDING SITE FOR CHAIN H OF CYCLOSPORIN A source : AC4 29) chain G residue 83 type sequence G description BINDING SITE FOR CHAIN H OF CYCLOSPORIN A source : AC4 30) chain G residue 112 type sequence A description BINDING SITE FOR CHAIN H OF CYCLOSPORIN A source : AC4 31) chain G residue 113 type sequence N description BINDING SITE FOR CHAIN H OF CYCLOSPORIN A source : AC4 32) chain G residue 114 type sequence K description BINDING SITE FOR CHAIN H OF CYCLOSPORIN A source : AC4 33) chain G residue 122 type sequence Q description BINDING SITE FOR CHAIN H OF CYCLOSPORIN A source : AC4 34) chain G residue 124 type sequence F description BINDING SITE FOR CHAIN H OF CYCLOSPORIN A source : AC4 35) chain G residue 132 type sequence H description BINDING SITE FOR CHAIN H OF CYCLOSPORIN A source : AC4 36) chain G residue 137 type sequence H description BINDING SITE FOR CHAIN H OF CYCLOSPORIN A source : AC4 37) chain O residue 132 type sequence H description BINDING SITE FOR CHAIN H OF CYCLOSPORIN A source : AC4 38) chain O residue 136 type sequence I description BINDING SITE FOR CHAIN H OF CYCLOSPORIN A source : AC4 39) chain I residue 66 type sequence R description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : AC5 40) chain I residue 71 type sequence F description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : AC5 41) chain I residue 74 type sequence Q description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : AC5 42) chain I residue 83 type sequence G description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : AC5 43) chain I residue 112 type sequence A description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : AC5 44) chain I residue 113 type sequence N description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : AC5 45) chain I residue 114 type sequence K description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : AC5 46) chain I residue 122 type sequence Q description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : AC5 47) chain I residue 124 type sequence F description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : AC5 48) chain I residue 132 type sequence H description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : AC5 49) chain I residue 137 type sequence H description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : AC5 50) chain C residue 46 type sequence M description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : AC6 51) chain C residue 47 type sequence A description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : AC6 52) chain C residue 89 type sequence I description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : AC6 53) chain C residue 34 type sequence R description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : AC7 54) chain E residue 34 type sequence R description BINDING SITE FOR CHAIN P OF CYCLOSPORIN A source : AC8 55) chain E residue 90 type sequence Y description BINDING SITE FOR CHAIN P OF CYCLOSPORIN A source : AC8 56) chain G residue 132 type sequence H description BINDING SITE FOR CHAIN P OF CYCLOSPORIN A source : AC8 57) chain O residue 66 type sequence R description BINDING SITE FOR CHAIN P OF CYCLOSPORIN A source : AC8 58) chain O residue 71 type sequence F description BINDING SITE FOR CHAIN P OF CYCLOSPORIN A source : AC8 59) chain O residue 74 type sequence Q description BINDING SITE FOR CHAIN P OF CYCLOSPORIN A source : AC8 60) chain O residue 83 type sequence G description BINDING SITE FOR CHAIN P OF CYCLOSPORIN A source : AC8 61) chain O residue 112 type sequence A description BINDING SITE FOR CHAIN P OF CYCLOSPORIN A source : AC8 62) chain O residue 113 type sequence N description BINDING SITE FOR CHAIN P OF CYCLOSPORIN A source : AC8 63) chain O residue 114 type sequence K description BINDING SITE FOR CHAIN P OF CYCLOSPORIN A source : AC8 64) chain O residue 122 type sequence Q description BINDING SITE FOR CHAIN P OF CYCLOSPORIN A source : AC8 65) chain O residue 124 type sequence F description BINDING SITE FOR CHAIN P OF CYCLOSPORIN A source : AC8 66) chain O residue 132 type sequence H description BINDING SITE FOR CHAIN P OF CYCLOSPORIN A source : AC8 67) chain O residue 137 type sequence H description BINDING SITE FOR CHAIN P OF CYCLOSPORIN A source : AC8

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