eF-site ID 1c4z-ABCD PDB Code 1c4z Chain A, B, C, D click to enlarge Title STRUCTURE OF AN E6AP-UBCH7 COMPLEX: INSIGHTS INTO THE UBIQUITINATION PATHWAY Classification LIGASE Compound UBIQUITIN-PROTEIN LIGASE E3A Source (UB2L3_HUMAN) Sequence A:  NPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEF EGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLF WFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMIT FQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSD YILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTD EQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPT SHTCFNVLLLPEYSSKEKLKERLLKAITYA B:  NPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEF EGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLF WFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMIT FQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSD YILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTD EQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPT SHTCFNVLLLPEYSSKEKLKERLLKAITYA C:  NPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEF EGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLF WFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMIT FQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSD YILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTD EQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPT SHTCFNVLLLPEYSSKEKLKERLLKAITYA D:  SRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDN PPYDKGAFRIEINFPAEYPFKPPKITFKTKIYHPNIDEKG QVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRA DLAEEYSKDRKKFCKNAEEFTKKY Description Functional site 1) chain D residue 86 type catalytic sequence C description 438 source MCSA : MCSA1 2) chain A residue 539 type catalytic sequence E description 438 source MCSA : MCSA1 3) chain A residue 550 type catalytic sequence E description 438 source MCSA : MCSA1 4) chain A residue 607 type catalytic sequence D description 438 source MCSA : MCSA1 5) chain A residue 818 type catalytic sequence H description 438 source MCSA : MCSA1 6) chain A residue 820 type catalytic sequence C description 438 source MCSA : MCSA1 7) chain B residue 506 type catalytic sequence R description 438 source MCSA : MCSA2 8) chain B residue 539 type catalytic sequence E description 438 source MCSA : MCSA2 9) chain B residue 550 type catalytic sequence E description 438 source MCSA : MCSA2 10) chain B residue 607 type catalytic sequence D description 438 source MCSA : MCSA2 11) chain B residue 818 type catalytic sequence H description 438 source MCSA : MCSA2 12) chain B residue 820 type catalytic sequence C description 438 source MCSA : MCSA2 13) chain C residue 506 type catalytic sequence R description 438 source MCSA : MCSA3 14) chain C residue 539 type catalytic sequence E description 438 source MCSA : MCSA3 15) chain C residue 550 type catalytic sequence E description 438 source MCSA : MCSA3 16) chain C residue 607 type catalytic sequence D description 438 source MCSA : MCSA3 17) chain C residue 818 type catalytic sequence H description 438 source MCSA : MCSA3 18) chain C residue 820 type catalytic sequence C description 438 source MCSA : MCSA3 19) chain D residue 75-90 type prosite sequence YHPNIDEKGQVCLPVI description UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNIdek.GqVCLpvI source prosite : PS00183 20) chain D residue 86 type ACT_SITE sequence C description Glycyl thioester intermediate => ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133 source Swiss-Prot : SWS_FT_FI1 21) chain B residue 820 type ACT_SITE sequence C description Glycyl thioester intermediate => ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133 source Swiss-Prot : SWS_FT_FI1 22) chain C residue 820 type ACT_SITE sequence C description Glycyl thioester intermediate => ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133 source Swiss-Prot : SWS_FT_FI1 23) chain D residue 131 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 24) chain B residue 636 type MOD_RES sequence Y description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 25) chain C residue 636 type MOD_RES sequence Y description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2

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