eF-site ID 1c3o-G PDB Code 1c3o Chain G click to enlarge Title CRYSTAL STRUCTURE OF THE CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTANT C269S WITH BOUND GLUTAMINE Classification LIGASE Compound CARBAMOYL PHOSPHATE SYNTHETASE: LARGE SUBUNIT Source (CARA_ECOLI) Sequence G:  MPKRTDIKSILILGAGPIVIGQACEFDYSGAQACKALREE GYRVILVNSNPATIMTDPEMADATYIEPIHWEVVRKIIEK ERPDAVLPTMGGQTALNCALELERQGVLEEFGVTMIGATA DAIDKAEDRRRFDVAMKKIGLETARSGIAHTMEEALAVAA DVGFPCIIRPSFTMGGSGGGIAYNREEFEEICARGLDLSP TKELLIDESLIGWKEYEMEVVRDKNDNCIIVCSIENFDAM GIHTGDSITVAPAQTLTDKEYQIMRNASMAVLREIGVETG GSNVQFAVNPKNGRLIVIEMNPRVSRSSALASKATGFPIA KVAAKLAVGYTLDELMNDITGGRTPASFEPSIDYVVTKIP RFNFEKFAGANDRLTTQMKSVGEVMAIGRTQQESLQKALR GLEVGATGFDPKVSLDDPEALTKIRRELKDAGADRIWYIA DAFRAGLSVDGVFNLTNIDRWFLVQIEELVRLEEKVAEVG ITGLNADFLRQLKRKGFADARLAKLAGVREAEIRKLRDQY DLHPVYKRVDTCAAEFATDTAYMYSTYEEECEANPSTDRE KIMVLGGGPNRIGQGIEFDYCCVHASLALREDGYETIMVN CNPETVSTDYDTSDRLYFEPVTLEDVLEIVRIEKPKGVIV QYGGQTPLKLARALEAAGVPVIGTSPDAIDRAEDRERFQH AVERLKLKQPANATVTAIEMAVEKAKEIGYPLVVRPAMEI VYDEADLRRYFQTAVLLDHFLDDAVEVDVDAICDGEMVLI GGIMEHIEQAGVHSGDSACSLPAYTLSQEIQDVMRQQVQK LAFELQVRGLMNVQFAVKNNEVYLIEVNPRAARTVPFVSK ATGVPLAKVAARVMAGKSLAEQGVTKEVIPPYYSVKEVVL PFNKFPGVDPLLGPEMRSTGEVMGVGRTFAEAFAKAQLGS NSTMKKHGRALLSVREGDKERVVDLAAKLLKQGFELDATH GTAIVLGEAGINPRLVNKVHEGRPHIQDRIKNGEYTYIIN TTSGRRAIEDSRVIRRSALQYKVHYDTTLNGGFATAMALN ADATEKVISVQEMHAQIK Description Functional site 1) chain G residue 299 type sequence E description BINDING SITE FOR RESIDUE MN G 4069 source : CC4 2) chain G residue 301 type sequence N description BINDING SITE FOR RESIDUE MN G 4069 source : CC4 3) chain G residue 285 type sequence Q description BINDING SITE FOR RESIDUE MN G 4070 source : CC6 4) chain G residue 299 type sequence E description BINDING SITE FOR RESIDUE MN G 4070 source : CC6 5) chain G residue 215 type sequence E description BINDING SITE FOR RESIDUE K G 4071 source : CC8 6) chain G residue 236 type sequence N description BINDING SITE FOR RESIDUE K G 4071 source : CC8 7) chain G residue 238 type sequence D description BINDING SITE FOR RESIDUE K G 4071 source : CC8 8) chain G residue 239 type sequence A description BINDING SITE FOR RESIDUE K G 4071 source : CC8 9) chain G residue 242 type sequence I description BINDING SITE FOR RESIDUE K G 4071 source : CC8 10) chain G residue 247 type sequence S description BINDING SITE FOR RESIDUE K G 4071 source : CC8 11) chain G residue 126 type sequence A description BINDING SITE FOR RESIDUE K G 4072 source : DC1 12) chain G residue 127 type sequence E description BINDING SITE FOR RESIDUE K G 4072 source : DC1 13) chain G residue 299 type sequence E description BINDING SITE FOR RESIDUE K G 4072 source : DC1 14) chain G residue 300 type sequence M description BINDING SITE FOR RESIDUE K G 4072 source : DC1 15) chain G residue 301 type sequence N description BINDING SITE FOR RESIDUE K G 4072 source : DC1 16) chain G residue 829 type sequence Q description BINDING SITE FOR RESIDUE MN G 4075 source : DC3 17) chain G residue 841 type sequence E description BINDING SITE FOR RESIDUE MN G 4075 source : DC3 18) chain G residue 841 type sequence E description BINDING SITE FOR RESIDUE K G 4076 source : DC5 19) chain G residue 843 type sequence N description BINDING SITE FOR RESIDUE K G 4076 source : DC5 20) chain G residue 761 type sequence E description BINDING SITE FOR RESIDUE K G 4077 source : DC7 21) chain G residue 781 type sequence H description BINDING SITE FOR RESIDUE K G 4077 source : DC7 22) chain G residue 783 type sequence E description BINDING SITE FOR RESIDUE K G 4077 source : DC7 23) chain G residue 784 type sequence Q description BINDING SITE FOR RESIDUE K G 4077 source : DC7 24) chain G residue 787 type sequence V description BINDING SITE FOR RESIDUE K G 4077 source : DC7 25) chain G residue 792 type sequence S description BINDING SITE FOR RESIDUE K G 4077 source : DC7 26) chain G residue 93 type sequence Q description BINDING SITE FOR RESIDUE CL G 4082 source : DC9 27) chain G residue 173 type sequence T description BINDING SITE FOR RESIDUE CL G 4082 source : DC9 28) chain G residue 174 type sequence M description BINDING SITE FOR RESIDUE CL G 4082 source : DC9 29) chain G residue 289 type sequence N description BINDING SITE FOR RESIDUE CL G 4083 source : EC2 30) chain G residue 292 type sequence N description BINDING SITE FOR RESIDUE CL G 4083 source : EC2 31) chain G residue 294 type sequence R description BINDING SITE FOR RESIDUE CL G 4083 source : EC2 32) chain G residue 371 type sequence N description BINDING SITE FOR RESIDUE CL G 4084 source : EC4 33) chain G residue 901 type sequence P description BINDING SITE FOR RESIDUE CL G 4084 source : EC4 34) chain G residue 902 type sequence G description BINDING SITE FOR RESIDUE CL G 4084 source : EC4 35) chain G residue 217 type sequence E description BINDING SITE FOR RESIDUE K G 4087 source : FC1 36) chain G residue 244 type sequence T description BINDING SITE FOR RESIDUE K G 4087 source : FC1 37) chain G residue 283 type sequence N description BINDING SITE FOR RESIDUE K G 4087 source : FC1 38) chain G residue 285 type sequence Q description BINDING SITE FOR RESIDUE K G 4087 source : FC1 39) chain G residue 84 type sequence D description BINDING SITE FOR RESIDUE K G 4088 source : FC3 40) chain G residue 112 type sequence G description BINDING SITE FOR RESIDUE K G 4088 source : FC3 41) chain G residue 114 type sequence T description BINDING SITE FOR RESIDUE K G 4088 source : FC3 42) chain G residue 143 type sequence T description BINDING SITE FOR RESIDUE K G 4089 source : FC5 43) chain G residue 144 type sequence A description BINDING SITE FOR RESIDUE K G 4089 source : FC5 44) chain G residue 174 type sequence M description BINDING SITE FOR RESIDUE PO4 G 4073 source : GC9 45) chain G residue 175 type sequence G description BINDING SITE FOR RESIDUE PO4 G 4073 source : GC9 46) chain G residue 243 type sequence H description BINDING SITE FOR RESIDUE PO4 G 4073 source : GC9 47) chain G residue 285 type sequence Q description BINDING SITE FOR RESIDUE PO4 G 4073 source : GC9 48) chain G residue 299 type sequence E description BINDING SITE FOR RESIDUE PO4 G 4073 source : GC9 49) chain G residue 301 type sequence N description BINDING SITE FOR RESIDUE PO4 G 4073 source : GC9 50) chain G residue 303 type sequence R description BINDING SITE FOR RESIDUE PO4 G 4073 source : GC9 51) chain G residue 306 type sequence R description BINDING SITE FOR RESIDUE PO4 G 4073 source : GC9 52) chain G residue 129 type sequence R description BINDING SITE FOR RESIDUE ADP G 4068 source : IC4 53) chain G residue 167 type sequence I description BINDING SITE FOR RESIDUE ADP G 4068 source : IC4 54) chain G residue 169 type sequence R description BINDING SITE FOR RESIDUE ADP G 4068 source : IC4 55) chain G residue 173 type sequence T description BINDING SITE FOR RESIDUE ADP G 4068 source : IC4 56) chain G residue 174 type sequence M description BINDING SITE FOR RESIDUE ADP G 4068 source : IC4 57) chain G residue 175 type sequence G description BINDING SITE FOR RESIDUE ADP G 4068 source : IC4 58) chain G residue 176 type sequence G description BINDING SITE FOR RESIDUE ADP G 4068 source : IC4 59) chain G residue 208 type sequence E description BINDING SITE FOR RESIDUE ADP G 4068 source : IC4 60) chain G residue 210 type sequence L description BINDING SITE FOR RESIDUE ADP G 4068 source : IC4 61) chain G residue 211 type sequence I description BINDING SITE FOR RESIDUE ADP G 4068 source : IC4 62) chain G residue 215 type sequence E description BINDING SITE FOR RESIDUE ADP G 4068 source : IC4 63) chain G residue 240 type sequence M description BINDING SITE FOR RESIDUE ADP G 4068 source : IC4 64) chain G residue 241 type sequence G description BINDING SITE FOR RESIDUE ADP G 4068 source : IC4 65) chain G residue 242 type sequence I description BINDING SITE FOR RESIDUE ADP G 4068 source : IC4 66) chain G residue 243 type sequence H description BINDING SITE FOR RESIDUE ADP G 4068 source : IC4 67) chain G residue 244 type sequence T description BINDING SITE FOR RESIDUE ADP G 4068 source : IC4 68) chain G residue 285 type sequence Q description BINDING SITE FOR RESIDUE ADP G 4068 source : IC4 69) chain G residue 299 type sequence E description BINDING SITE FOR RESIDUE ADP G 4068 source : IC4 70) chain G residue 715 type sequence R description BINDING SITE FOR RESIDUE ADP G 4074 source : IC5 71) chain G residue 725 type sequence M description BINDING SITE FOR RESIDUE ADP G 4074 source : IC5 72) chain G residue 754 type sequence H description BINDING SITE FOR RESIDUE ADP G 4074 source : IC5 73) chain G residue 755 type sequence F description BINDING SITE FOR RESIDUE ADP G 4074 source : IC5 74) chain G residue 756 type sequence L description BINDING SITE FOR RESIDUE ADP G 4074 source : IC5 75) chain G residue 761 type sequence E description BINDING SITE FOR RESIDUE ADP G 4074 source : IC5 76) chain G residue 785 type sequence A description BINDING SITE FOR RESIDUE ADP G 4074 source : IC5 77) chain G residue 786 type sequence G description BINDING SITE FOR RESIDUE ADP G 4074 source : IC5 78) chain G residue 787 type sequence V description BINDING SITE FOR RESIDUE ADP G 4074 source : IC5 79) chain G residue 788 type sequence H description BINDING SITE FOR RESIDUE ADP G 4074 source : IC5 80) chain G residue 789 type sequence S description BINDING SITE FOR RESIDUE ADP G 4074 source : IC5 81) chain G residue 829 type sequence Q description BINDING SITE FOR RESIDUE ADP G 4074 source : IC5 82) chain G residue 841 type sequence E description BINDING SITE FOR RESIDUE ADP G 4074 source : IC5 83) chain G residue 783 type sequence E description BINDING SITE FOR RESIDUE ORN G 4078 source : IC6 84) chain G residue 791 type sequence D description BINDING SITE FOR RESIDUE ORN G 4078 source : IC6 85) chain G residue 892 type sequence E description BINDING SITE FOR RESIDUE ORN G 4078 source : IC6 86) chain G residue 893 type sequence V description BINDING SITE FOR RESIDUE ORN G 4078 source : IC6 87) chain G residue 907 type sequence L description BINDING SITE FOR RESIDUE ORN G 4078 source : IC6 88) chain G residue 1040 type sequence Y description BINDING SITE FOR RESIDUE ORN G 4078 source : IC6 89) chain G residue 1041 type sequence D description BINDING SITE FOR RESIDUE ORN G 4078 source : IC6 90) chain G residue 1042 type sequence T description BINDING SITE FOR RESIDUE ORN G 4078 source : IC6 91) chain G residue 528 type sequence R description BINDING SITE FOR RESIDUE GLN G 4080 source : IC9 92) chain G residue 537 type sequence A description BINDING SITE FOR RESIDUE GLN G 4080 source : IC9 93) chain G residue 538 type sequence T description BINDING SITE FOR RESIDUE GLN G 4080 source : IC9 94) chain G residue 552 type sequence E description BINDING SITE FOR RESIDUE GLN G 4080 source : IC9 95) chain G residue 554 type sequence N description BINDING SITE FOR RESIDUE GLN G 4080 source : IC9 96) chain G residue 19 type sequence V description BINDING SITE FOR RESIDUE NET G 4081 source : JC2 97) chain G residue 94 type sequence T description BINDING SITE FOR RESIDUE NET G 4081 source : JC2 98) chain G residue 97 type sequence N description BINDING SITE FOR RESIDUE NET G 4081 source : JC2 99) chain G residue 303 type catalytic sequence R description 435 source MCSA : MCSA4 100) chain G residue 715 type catalytic sequence R description 435 source MCSA : MCSA4 101) chain G residue 761 type catalytic sequence E description 435 source MCSA : MCSA4 102) chain G residue 829 type catalytic sequence Q description 435 source MCSA : MCSA4 103) chain G residue 841 type catalytic sequence E description 435 source MCSA : MCSA4 104) chain G residue 843 type catalytic sequence N description 435 source MCSA : MCSA4 105) chain G residue 848 type catalytic sequence R description 435 source MCSA : MCSA4 106) chain G residue 215 type catalytic sequence E description 435 source MCSA : MCSA4 107) chain G residue 243 type catalytic sequence H description 435 source MCSA : MCSA4 108) chain G residue 283 type catalytic sequence N description 435 source MCSA : MCSA4 109) chain G residue 285 type catalytic sequence Q description 435 source MCSA : MCSA4 110) chain G residue 299 type catalytic sequence E description 435 source MCSA : MCSA4 111) chain G residue 301 type catalytic sequence N description 435 source MCSA : MCSA4 112) chain G residue 829 type BINDING sequence Q description BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10428826, ECO:0000269|PubMed:9636022, ECO:0007744|PDB:1CE8 source Swiss-Prot : SWS_FT_FI4 113) chain G residue 129 type ACT_SITE sequence R description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 114) chain G residue 169 type ACT_SITE sequence R description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 115) chain G residue 175 type ACT_SITE sequence G description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 116) chain G residue 176 type ACT_SITE sequence G description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 117) chain G residue 208 type ACT_SITE sequence E description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 118) chain G residue 210 type ACT_SITE sequence L description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 119) chain G residue 215 type ACT_SITE sequence E description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 120) chain G residue 241 type ACT_SITE sequence G description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 121) chain G residue 242 type ACT_SITE sequence I description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 122) chain G residue 243 type ACT_SITE sequence H description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 123) chain G residue 715 type ACT_SITE sequence R description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 124) chain G residue 754 type ACT_SITE sequence H description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 125) chain G residue 756 type ACT_SITE sequence L description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 126) chain G residue 761 type ACT_SITE sequence E description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 127) chain G residue 786 type ACT_SITE sequence G description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 128) chain G residue 787 type ACT_SITE sequence V description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 129) chain G residue 788 type ACT_SITE sequence H description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 130) chain G residue 789 type ACT_SITE sequence S description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 131) chain G residue 843 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10029528, ECO:0000269|PubMed:10089390 source Swiss-Prot : SWS_FT_FI6 132) chain G residue 841 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10029528, ECO:0000269|PubMed:10089390, ECO:0000269|PubMed:10428826, ECO:0000269|PubMed:9636022, ECO:0007744|PDB:1CE8 source Swiss-Prot : SWS_FT_FI5

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