eF-site ID 1c3o-C PDB Code 1c3o Chain C click to enlarge Title CRYSTAL STRUCTURE OF THE CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTANT C269S WITH BOUND GLUTAMINE Classification LIGASE Compound CARBAMOYL PHOSPHATE SYNTHETASE: LARGE SUBUNIT Source (CARA_ECOLI) Sequence C:  MPKRTDIKSILILGAGPIVIGQACEFDYSGAQACKALREE GYRVILVNSNPATIMTDPEMADATYIEPIHWEVVRKIIEK ERPDAVLPTMGGQTALNCALELERQGVLEEFGVTMIGATA DAIDKAEDRRRFDVAMKKIGLETARSGIAHTMEEALAVAA DVGFPCIIRPSFTMGGSGGGIAYNREEFEEICARGLDLSP TKELLIDESLIGWKEYEMEVVRDKNDNCIIVCSIENFDAM GIHTGDSITVAPAQTLTDKEYQIMRNASMAVLREIGVETG GSNVQFAVNPKNGRLIVIEMNPRVSRSSALASKATGFPIA KVAAKLAVGYTLDELMNDITGGRTPASFEPSIDYVVTKIP RFNFEKFAGANDRLTTQMKSVGEVMAIGRTQQESLQKALR GLEVGATGFDPKVSLDDPEALTKIRRELKDAGADRIWYIA DAFRAGLSVDGVFNLTNIDRWFLVQIEELVRLEEKVAEVG ITGLNADFLRQLKRKGFADARLAKLAGVREAEIRKLRDQY DLHPVYKRVDTCAAEFATDTAYMYSTYEEECEANPSTDRE KIMVLGGGPNRIGQGIEFDYCCVHASLALREDGYETIMVN CNPETVSTDYDTSDRLYFEPVTLEDVLEIVRIEKPKGVIV QYGGQTPLKLARALEAAGVPVIGTSPDAIDRAEDRERFQH AVERLKLKQPANATVTAIEMAVEKAKEIGYPLVVRPAMEI VYDEADLRRYFQTAVLLDHFLDDAVEVDVDAICDGEMVLI GGIMEHIEQAGVHSGDSACSLPAYTLSQEIQDVMRQQVQK LAFELQVRGLMNVQFAVKNNEVYLIEVNPRAARTVPFVSK ATGVPLAKVAARVMAGKSLAEQGVTKEVIPPYYSVKEVVL PFNKFPGVDPLLGPEMRSTGEVMGVGRTFAEAFAKAQLGS NSTMKKHGRALLSVREGDKERVVDLAAKLLKQGFELDATH GTAIVLGEAGINPRLVNKVHEGRPHIQDRIKNGEYTYIIN TTSGRRAIEDSRVIRRSALQYKVHYDTTLNGGFATAMALN ADATEKVISVQEMHAQIK Description Functional site 1) chain C residue 299 type sequence E description BINDING SITE FOR RESIDUE MN C 4024 source : BC7 2) chain C residue 301 type sequence N description BINDING SITE FOR RESIDUE MN C 4024 source : BC7 3) chain C residue 285 type sequence Q description BINDING SITE FOR RESIDUE MN C 4025 source : BC8 4) chain C residue 299 type sequence E description BINDING SITE FOR RESIDUE MN C 4025 source : BC8 5) chain C residue 215 type sequence E description BINDING SITE FOR RESIDUE K C 4026 source : BC9 6) chain C residue 236 type sequence N description BINDING SITE FOR RESIDUE K C 4026 source : BC9 7) chain C residue 238 type sequence D description BINDING SITE FOR RESIDUE K C 4026 source : BC9 8) chain C residue 239 type sequence A description BINDING SITE FOR RESIDUE K C 4026 source : BC9 9) chain C residue 242 type sequence I description BINDING SITE FOR RESIDUE K C 4026 source : BC9 10) chain C residue 247 type sequence S description BINDING SITE FOR RESIDUE K C 4026 source : BC9 11) chain C residue 126 type sequence A description BINDING SITE FOR RESIDUE K C 4027 source : CC1 12) chain C residue 127 type sequence E description BINDING SITE FOR RESIDUE K C 4027 source : CC1 13) chain C residue 299 type sequence E description BINDING SITE FOR RESIDUE K C 4027 source : CC1 14) chain C residue 300 type sequence M description BINDING SITE FOR RESIDUE K C 4027 source : CC1 15) chain C residue 301 type sequence N description BINDING SITE FOR RESIDUE K C 4027 source : CC1 16) chain C residue 829 type sequence Q description BINDING SITE FOR RESIDUE MN C 4030 source : CC3 17) chain C residue 841 type sequence E description BINDING SITE FOR RESIDUE MN C 4030 source : CC3 18) chain C residue 841 type sequence E description BINDING SITE FOR RESIDUE K C 4031 source : CC5 19) chain C residue 843 type sequence N description BINDING SITE FOR RESIDUE K C 4031 source : CC5 20) chain C residue 761 type sequence E description BINDING SITE FOR RESIDUE K C 4032 source : CC7 21) chain C residue 781 type sequence H description BINDING SITE FOR RESIDUE K C 4032 source : CC7 22) chain C residue 783 type sequence E description BINDING SITE FOR RESIDUE K C 4032 source : CC7 23) chain C residue 784 type sequence Q description BINDING SITE FOR RESIDUE K C 4032 source : CC7 24) chain C residue 787 type sequence V description BINDING SITE FOR RESIDUE K C 4032 source : CC7 25) chain C residue 792 type sequence S description BINDING SITE FOR RESIDUE K C 4032 source : CC7 26) chain C residue 173 type sequence T description BINDING SITE FOR RESIDUE CL C 4037 source : CC9 27) chain C residue 174 type sequence M description BINDING SITE FOR RESIDUE CL C 4037 source : CC9 28) chain C residue 289 type sequence N description BINDING SITE FOR RESIDUE CL C 4038 source : DC2 29) chain C residue 292 type sequence N description BINDING SITE FOR RESIDUE CL C 4038 source : DC2 30) chain C residue 294 type sequence R description BINDING SITE FOR RESIDUE CL C 4038 source : DC2 31) chain C residue 371 type sequence N description BINDING SITE FOR RESIDUE CL C 4039 source : DC4 32) chain C residue 900 type sequence F description BINDING SITE FOR RESIDUE CL C 4039 source : DC4 33) chain C residue 901 type sequence P description BINDING SITE FOR RESIDUE CL C 4039 source : DC4 34) chain C residue 902 type sequence G description BINDING SITE FOR RESIDUE CL C 4039 source : DC4 35) chain C residue 549 type sequence E description BINDING SITE FOR RESIDUE CL D 4040 source : DC6 36) chain C residue 490 type sequence R description BINDING SITE FOR RESIDUE K D 4041 source : DC8 37) chain C residue 217 type sequence E description BINDING SITE FOR RESIDUE K C 4042 source : EC1 38) chain C residue 244 type sequence T description BINDING SITE FOR RESIDUE K C 4042 source : EC1 39) chain C residue 283 type sequence N description BINDING SITE FOR RESIDUE K C 4042 source : EC1 40) chain C residue 285 type sequence Q description BINDING SITE FOR RESIDUE K C 4042 source : EC1 41) chain C residue 84 type sequence D description BINDING SITE FOR RESIDUE K C 4043 source : EC3 42) chain C residue 112 type sequence G description BINDING SITE FOR RESIDUE K C 4043 source : EC3 43) chain C residue 114 type sequence T description BINDING SITE FOR RESIDUE K C 4043 source : EC3 44) chain C residue 143 type sequence T description BINDING SITE FOR RESIDUE K C 4044 source : EC5 45) chain C residue 144 type sequence A description BINDING SITE FOR RESIDUE K C 4044 source : EC5 46) chain C residue 174 type sequence M description BINDING SITE FOR RESIDUE PO4 C 4028 source : HC2 47) chain C residue 175 type sequence G description BINDING SITE FOR RESIDUE PO4 C 4028 source : HC2 48) chain C residue 243 type sequence H description BINDING SITE FOR RESIDUE PO4 C 4028 source : HC2 49) chain C residue 285 type sequence Q description BINDING SITE FOR RESIDUE PO4 C 4028 source : HC2 50) chain C residue 299 type sequence E description BINDING SITE FOR RESIDUE PO4 C 4028 source : HC2 51) chain C residue 301 type sequence N description BINDING SITE FOR RESIDUE PO4 C 4028 source : HC2 52) chain C residue 303 type sequence R description BINDING SITE FOR RESIDUE PO4 C 4028 source : HC2 53) chain C residue 306 type sequence R description BINDING SITE FOR RESIDUE PO4 C 4028 source : HC2 54) chain C residue 783 type sequence E description BINDING SITE FOR RESIDUE ORN C 4033 source : HC3 55) chain C residue 791 type sequence D description BINDING SITE FOR RESIDUE ORN C 4033 source : HC3 56) chain C residue 892 type sequence E description BINDING SITE FOR RESIDUE ORN C 4033 source : HC3 57) chain C residue 907 type sequence L description BINDING SITE FOR RESIDUE ORN C 4033 source : HC3 58) chain C residue 1040 type sequence Y description BINDING SITE FOR RESIDUE ORN C 4033 source : HC3 59) chain C residue 1041 type sequence D description BINDING SITE FOR RESIDUE ORN C 4033 source : HC3 60) chain C residue 1042 type sequence T description BINDING SITE FOR RESIDUE ORN C 4033 source : HC3 61) chain C residue 528 type sequence R description BINDING SITE FOR RESIDUE GLN C 4035 source : HC5 62) chain C residue 537 type sequence A description BINDING SITE FOR RESIDUE GLN C 4035 source : HC5 63) chain C residue 538 type sequence T description BINDING SITE FOR RESIDUE GLN C 4035 source : HC5 64) chain C residue 552 type sequence E description BINDING SITE FOR RESIDUE GLN C 4035 source : HC5 65) chain C residue 554 type sequence N description BINDING SITE FOR RESIDUE GLN C 4035 source : HC5 66) chain C residue 22 type sequence Q description BINDING SITE FOR RESIDUE NET C 4036 source : HC6 67) chain C residue 94 type sequence T description BINDING SITE FOR RESIDUE NET C 4036 source : HC6 68) chain C residue 97 type sequence N description BINDING SITE FOR RESIDUE NET C 4036 source : HC6 69) chain C residue 936 type sequence N description BINDING SITE FOR RESIDUE NET C 4036 source : HC6 70) chain C residue 129 type sequence R description BINDING SITE FOR RESIDUE ADP C 4023 source : JC7 71) chain C residue 167 type sequence I description BINDING SITE FOR RESIDUE ADP C 4023 source : JC7 72) chain C residue 169 type sequence R description BINDING SITE FOR RESIDUE ADP C 4023 source : JC7 73) chain C residue 173 type sequence T description BINDING SITE FOR RESIDUE ADP C 4023 source : JC7 74) chain C residue 174 type sequence M description BINDING SITE FOR RESIDUE ADP C 4023 source : JC7 75) chain C residue 175 type sequence G description BINDING SITE FOR RESIDUE ADP C 4023 source : JC7 76) chain C residue 176 type sequence G description BINDING SITE FOR RESIDUE ADP C 4023 source : JC7 77) chain C residue 208 type sequence E description BINDING SITE FOR RESIDUE ADP C 4023 source : JC7 78) chain C residue 210 type sequence L description BINDING SITE FOR RESIDUE ADP C 4023 source : JC7 79) chain C residue 211 type sequence I description BINDING SITE FOR RESIDUE ADP C 4023 source : JC7 80) chain C residue 215 type sequence E description BINDING SITE FOR RESIDUE ADP C 4023 source : JC7 81) chain C residue 240 type sequence M description BINDING SITE FOR RESIDUE ADP C 4023 source : JC7 82) chain C residue 241 type sequence G description BINDING SITE FOR RESIDUE ADP C 4023 source : JC7 83) chain C residue 242 type sequence I description BINDING SITE FOR RESIDUE ADP C 4023 source : JC7 84) chain C residue 243 type sequence H description BINDING SITE FOR RESIDUE ADP C 4023 source : JC7 85) chain C residue 244 type sequence T description BINDING SITE FOR RESIDUE ADP C 4023 source : JC7 86) chain C residue 285 type sequence Q description BINDING SITE FOR RESIDUE ADP C 4023 source : JC7 87) chain C residue 298 type sequence I description BINDING SITE FOR RESIDUE ADP C 4023 source : JC7 88) chain C residue 299 type sequence E description BINDING SITE FOR RESIDUE ADP C 4023 source : JC7 89) chain C residue 376 type sequence T description BINDING SITE FOR RESIDUE ADP C 4023 source : JC7 90) chain C residue 690 type sequence P description BINDING SITE FOR RESIDUE ADP C 4029 source : JC8 91) chain C residue 715 type sequence R description BINDING SITE FOR RESIDUE ADP C 4029 source : JC8 92) chain C residue 725 type sequence M description BINDING SITE FOR RESIDUE ADP C 4029 source : JC8 93) chain C residue 754 type sequence H description BINDING SITE FOR RESIDUE ADP C 4029 source : JC8 94) chain C residue 755 type sequence F description BINDING SITE FOR RESIDUE ADP C 4029 source : JC8 95) chain C residue 756 type sequence L description BINDING SITE FOR RESIDUE ADP C 4029 source : JC8 96) chain C residue 761 type sequence E description BINDING SITE FOR RESIDUE ADP C 4029 source : JC8 97) chain C residue 785 type sequence A description BINDING SITE FOR RESIDUE ADP C 4029 source : JC8 98) chain C residue 786 type sequence G description BINDING SITE FOR RESIDUE ADP C 4029 source : JC8 99) chain C residue 787 type sequence V description BINDING SITE FOR RESIDUE ADP C 4029 source : JC8 100) chain C residue 788 type sequence H description BINDING SITE FOR RESIDUE ADP C 4029 source : JC8 101) chain C residue 789 type sequence S description BINDING SITE FOR RESIDUE ADP C 4029 source : JC8 102) chain C residue 829 type sequence Q description BINDING SITE FOR RESIDUE ADP C 4029 source : JC8 103) chain C residue 841 type sequence E description BINDING SITE FOR RESIDUE ADP C 4029 source : JC8 104) chain C residue 215 type catalytic sequence E description 435 source MCSA : MCSA2 105) chain C residue 243 type catalytic sequence H description 435 source MCSA : MCSA2 106) chain C residue 283 type catalytic sequence N description 435 source MCSA : MCSA2 107) chain C residue 285 type catalytic sequence Q description 435 source MCSA : MCSA2 108) chain C residue 299 type catalytic sequence E description 435 source MCSA : MCSA2 109) chain C residue 301 type catalytic sequence N description 435 source MCSA : MCSA2 110) chain C residue 303 type catalytic sequence R description 435 source MCSA : MCSA2 111) chain C residue 715 type catalytic sequence R description 435 source MCSA : MCSA2 112) chain C residue 761 type catalytic sequence E description 435 source MCSA : MCSA2 113) chain C residue 829 type catalytic sequence Q description 435 source MCSA : MCSA2 114) chain C residue 841 type catalytic sequence E description 435 source MCSA : MCSA2 115) chain C residue 843 type catalytic sequence N description 435 source MCSA : MCSA2 116) chain C residue 848 type catalytic sequence R description 435 source MCSA : MCSA2 117) chain C residue 843 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10029528, ECO:0000269|PubMed:10089390 source Swiss-Prot : SWS_FT_FI6 118) chain C residue 129 type ACT_SITE sequence R description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 119) chain C residue 169 type ACT_SITE sequence R description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 120) chain C residue 175 type ACT_SITE sequence G description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 121) chain C residue 176 type ACT_SITE sequence G description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 122) chain C residue 208 type ACT_SITE sequence E description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 123) chain C residue 210 type ACT_SITE sequence L description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 124) chain C residue 215 type ACT_SITE sequence E description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 125) chain C residue 241 type ACT_SITE sequence G description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 126) chain C residue 242 type ACT_SITE sequence I description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 127) chain C residue 243 type ACT_SITE sequence H description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 128) chain C residue 715 type ACT_SITE sequence R description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 129) chain C residue 754 type ACT_SITE sequence H description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 130) chain C residue 756 type ACT_SITE sequence L description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 131) chain C residue 761 type ACT_SITE sequence E description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 132) chain C residue 786 type ACT_SITE sequence G description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 133) chain C residue 787 type ACT_SITE sequence V description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 134) chain C residue 788 type ACT_SITE sequence H description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 135) chain C residue 789 type ACT_SITE sequence S description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 136) chain C residue 841 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10029528, ECO:0000269|PubMed:10089390, ECO:0000269|PubMed:10428826, ECO:0000269|PubMed:9636022, ECO:0007744|PDB:1CE8 source Swiss-Prot : SWS_FT_FI5 137) chain C residue 829 type BINDING sequence Q description BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10428826, ECO:0000269|PubMed:9636022, ECO:0007744|PDB:1CE8 source Swiss-Prot : SWS_FT_FI4

Display surface Download Links