eF-site ID 1c3i-AB PDB Code 1c3i Chain A, B click to enlarge Title HUMAN STROMELYSIN-1 CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812 Classification HYDROLASE Compound STROMELYSIN-1 Source Homo sapiens (Human) (MMP3_HUMAN) Sequence A:  FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALK VWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGN VLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHE IGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGI QSLYGPPPDS B:  FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALK VWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGN VLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHE IGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGI QSLYGPPPDSPET Description Functional site 1) chain A residue 201 type sequence H description BINDING SITE FOR RESIDUE ZN A 260 source : AC1 2) chain A residue 205 type sequence H description BINDING SITE FOR RESIDUE ZN A 260 source : AC1 3) chain A residue 211 type sequence H description BINDING SITE FOR RESIDUE ZN A 260 source : AC1 4) chain B residue 255 type sequence T description BINDING SITE FOR RESIDUE ZN A 260 source : AC1 5) chain A residue 151 type sequence H description BINDING SITE FOR RESIDUE ZN A 261 source : AC2 6) chain A residue 153 type sequence D description BINDING SITE FOR RESIDUE ZN A 261 source : AC2 7) chain A residue 166 type sequence H description BINDING SITE FOR RESIDUE ZN A 261 source : AC2 8) chain A residue 179 type sequence H description BINDING SITE FOR RESIDUE ZN A 261 source : AC2 9) chain A residue 107 type sequence D description BINDING SITE FOR RESIDUE CA A 262 source : AC3 10) chain A residue 182 type sequence D description BINDING SITE FOR RESIDUE CA A 262 source : AC3 11) chain A residue 184 type sequence E description BINDING SITE FOR RESIDUE CA A 262 source : AC3 12) chain A residue 141 type sequence D description BINDING SITE FOR RESIDUE CA A 263 source : AC4 13) chain A residue 173 type sequence G description BINDING SITE FOR RESIDUE CA A 263 source : AC4 14) chain A residue 175 type sequence N description BINDING SITE FOR RESIDUE CA A 263 source : AC4 15) chain A residue 177 type sequence D description BINDING SITE FOR RESIDUE CA A 263 source : AC4 16) chain A residue 158 type sequence D description BINDING SITE FOR RESIDUE CA A 264 source : AC5 17) chain A residue 159 type sequence G description BINDING SITE FOR RESIDUE CA A 264 source : AC5 18) chain A residue 161 type sequence G description BINDING SITE FOR RESIDUE CA A 264 source : AC5 19) chain A residue 163 type sequence V description BINDING SITE FOR RESIDUE CA A 264 source : AC5 20) chain A residue 181 type sequence D description BINDING SITE FOR RESIDUE CA A 264 source : AC5 21) chain A residue 184 type sequence E description BINDING SITE FOR RESIDUE CA A 264 source : AC5 22) chain B residue 201 type sequence H description BINDING SITE FOR RESIDUE ZN B 260 source : AC6 23) chain B residue 205 type sequence H description BINDING SITE FOR RESIDUE ZN B 260 source : AC6 24) chain B residue 211 type sequence H description BINDING SITE FOR RESIDUE ZN B 260 source : AC6 25) chain B residue 151 type sequence H description BINDING SITE FOR RESIDUE ZN B 261 source : AC7 26) chain B residue 153 type sequence D description BINDING SITE FOR RESIDUE ZN B 261 source : AC7 27) chain B residue 166 type sequence H description BINDING SITE FOR RESIDUE ZN B 261 source : AC7 28) chain B residue 179 type sequence H description BINDING SITE FOR RESIDUE ZN B 261 source : AC7 29) chain B residue 107 type sequence D description BINDING SITE FOR RESIDUE CA B 262 source : AC8 30) chain B residue 182 type sequence D description BINDING SITE FOR RESIDUE CA B 262 source : AC8 31) chain B residue 184 type sequence E description BINDING SITE FOR RESIDUE CA B 262 source : AC8 32) chain B residue 141 type sequence D description BINDING SITE FOR RESIDUE CA B 263 source : AC9 33) chain B residue 173 type sequence G description BINDING SITE FOR RESIDUE CA B 263 source : AC9 34) chain B residue 175 type sequence N description BINDING SITE FOR RESIDUE CA B 263 source : AC9 35) chain B residue 177 type sequence D description BINDING SITE FOR RESIDUE CA B 263 source : AC9 36) chain B residue 158 type sequence D description BINDING SITE FOR RESIDUE CA B 264 source : BC1 37) chain B residue 159 type sequence G description BINDING SITE FOR RESIDUE CA B 264 source : BC1 38) chain B residue 161 type sequence G description BINDING SITE FOR RESIDUE CA B 264 source : BC1 39) chain B residue 163 type sequence V description BINDING SITE FOR RESIDUE CA B 264 source : BC1 40) chain B residue 181 type sequence D description BINDING SITE FOR RESIDUE CA B 264 source : BC1 41) chain B residue 184 type sequence E description BINDING SITE FOR RESIDUE CA B 264 source : BC1 42) chain B residue 93 type sequence R description BINDING SITE FOR RESIDUE TR1 B 1 source : BC2 43) chain B residue 162 type sequence N description BINDING SITE FOR RESIDUE TR1 B 1 source : BC2 44) chain B residue 163 type sequence V description BINDING SITE FOR RESIDUE TR1 B 1 source : BC2 45) chain B residue 164 type sequence L description BINDING SITE FOR RESIDUE TR1 B 1 source : BC2 46) chain B residue 165 type sequence A description BINDING SITE FOR RESIDUE TR1 B 1 source : BC2 47) chain B residue 201 type sequence H description BINDING SITE FOR RESIDUE TR1 B 1 source : BC2 48) chain B residue 202 type sequence E description BINDING SITE FOR RESIDUE TR1 B 1 source : BC2 49) chain B residue 205 type sequence H description BINDING SITE FOR RESIDUE TR1 B 1 source : BC2 50) chain B residue 211 type sequence H description BINDING SITE FOR RESIDUE TR1 B 1 source : BC2 51) chain B residue 217 type sequence A description BINDING SITE FOR RESIDUE TR1 B 1 source : BC2 52) chain B residue 218 type sequence L description BINDING SITE FOR RESIDUE TR1 B 1 source : BC2 53) chain B residue 220 type sequence Y description BINDING SITE FOR RESIDUE TR1 B 1 source : BC2 54) chain B residue 221 type sequence P description BINDING SITE FOR RESIDUE TR1 B 1 source : BC2 55) chain B residue 222 type sequence L description BINDING SITE FOR RESIDUE TR1 B 1 source : BC2 56) chain B residue 223 type sequence Y description BINDING SITE FOR RESIDUE TR1 B 1 source : BC2 57) chain A residue 107 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 58) chain A residue 173 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 59) chain A residue 175 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 60) chain A residue 177 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 61) chain A residue 179 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 62) chain A residue 181 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 63) chain A residue 182 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 64) chain A residue 184 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 65) chain B residue 107 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 66) chain B residue 141 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 67) chain B residue 151 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 68) chain A residue 141 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 69) chain B residue 153 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 70) chain B residue 158 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 71) chain B residue 159 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 72) chain B residue 161 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 73) chain B residue 163 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 74) chain B residue 166 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 75) chain B residue 173 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 76) chain B residue 175 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 77) chain B residue 177 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 78) chain B residue 179 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 79) chain A residue 151 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 80) chain B residue 181 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 81) chain B residue 182 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 82) chain B residue 184 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 83) chain A residue 153 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 84) chain A residue 158 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 85) chain A residue 159 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 86) chain A residue 161 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 87) chain A residue 163 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 88) chain A residue 166 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 89) chain A residue 201 type BINDING sequence H description BINDING => ECO:0000269|PubMed:8740360 source Swiss-Prot : SWS_FT_FI3 90) chain A residue 205 type BINDING sequence H description BINDING => ECO:0000269|PubMed:8740360 source Swiss-Prot : SWS_FT_FI3 91) chain A residue 211 type BINDING sequence H description BINDING => ECO:0000269|PubMed:8740360 source Swiss-Prot : SWS_FT_FI3 92) chain B residue 201 type BINDING sequence H description BINDING => ECO:0000269|PubMed:8740360 source Swiss-Prot : SWS_FT_FI3 93) chain B residue 205 type BINDING sequence H description BINDING => ECO:0000269|PubMed:8740360 source Swiss-Prot : SWS_FT_FI3 94) chain B residue 211 type BINDING sequence H description BINDING => ECO:0000269|PubMed:8740360 source Swiss-Prot : SWS_FT_FI3 95) chain A residue 202 type ACT_SITE sequence E description source Swiss-Prot : SWS_FT_FI1 96) chain B residue 202 type ACT_SITE sequence E description source Swiss-Prot : SWS_FT_FI1 97) chain A residue 201 type catalytic sequence H description 591 source MCSA : MCSA1 98) chain A residue 202 type catalytic sequence E description 591 source MCSA : MCSA1 99) chain A residue 205 type catalytic sequence H description 591 source MCSA : MCSA1 100) chain A residue 211 type catalytic sequence H description 591 source MCSA : MCSA1 101) chain B residue 201 type catalytic sequence H description 591 source MCSA : MCSA2 102) chain B residue 202 type catalytic sequence E description 591 source MCSA : MCSA2 103) chain B residue 205 type catalytic sequence H description 591 source MCSA : MCSA2 104) chain B residue 211 type catalytic sequence H description 591 source MCSA : MCSA2 105) chain A residue 198-207 type prosite sequence VAAHEIGHSL description ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEIGHSL source prosite : PS00142

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