eF-site ID 1c3i-A PDB Code 1c3i Chain A click to enlarge Title HUMAN STROMELYSIN-1 CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812 Classification HYDROLASE Compound STROMELYSIN-1 Source Homo sapiens (Human) (MMP3_HUMAN) Sequence A:  FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALK VWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGN VLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHE IGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGI QSLYGPPPDS Description Functional site 1) chain A residue 201 type sequence H description BINDING SITE FOR RESIDUE ZN A 260 source : AC1 2) chain A residue 205 type sequence H description BINDING SITE FOR RESIDUE ZN A 260 source : AC1 3) chain A residue 211 type sequence H description BINDING SITE FOR RESIDUE ZN A 260 source : AC1 4) chain A residue 151 type sequence H description BINDING SITE FOR RESIDUE ZN A 261 source : AC2 5) chain A residue 153 type sequence D description BINDING SITE FOR RESIDUE ZN A 261 source : AC2 6) chain A residue 166 type sequence H description BINDING SITE FOR RESIDUE ZN A 261 source : AC2 7) chain A residue 179 type sequence H description BINDING SITE FOR RESIDUE ZN A 261 source : AC2 8) chain A residue 107 type sequence D description BINDING SITE FOR RESIDUE CA A 262 source : AC3 9) chain A residue 182 type sequence D description BINDING SITE FOR RESIDUE CA A 262 source : AC3 10) chain A residue 184 type sequence E description BINDING SITE FOR RESIDUE CA A 262 source : AC3 11) chain A residue 141 type sequence D description BINDING SITE FOR RESIDUE CA A 263 source : AC4 12) chain A residue 173 type sequence G description BINDING SITE FOR RESIDUE CA A 263 source : AC4 13) chain A residue 175 type sequence N description BINDING SITE FOR RESIDUE CA A 263 source : AC4 14) chain A residue 177 type sequence D description BINDING SITE FOR RESIDUE CA A 263 source : AC4 15) chain A residue 158 type sequence D description BINDING SITE FOR RESIDUE CA A 264 source : AC5 16) chain A residue 159 type sequence G description BINDING SITE FOR RESIDUE CA A 264 source : AC5 17) chain A residue 161 type sequence G description BINDING SITE FOR RESIDUE CA A 264 source : AC5 18) chain A residue 163 type sequence V description BINDING SITE FOR RESIDUE CA A 264 source : AC5 19) chain A residue 181 type sequence D description BINDING SITE FOR RESIDUE CA A 264 source : AC5 20) chain A residue 184 type sequence E description BINDING SITE FOR RESIDUE CA A 264 source : AC5 21) chain A residue 107 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 22) chain A residue 173 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 23) chain A residue 175 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 24) chain A residue 177 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 25) chain A residue 179 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 26) chain A residue 181 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 27) chain A residue 182 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 28) chain A residue 184 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 29) chain A residue 141 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 30) chain A residue 151 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 31) chain A residue 153 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 32) chain A residue 158 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 33) chain A residue 159 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 34) chain A residue 161 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 35) chain A residue 163 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 36) chain A residue 166 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 37) chain A residue 201 type BINDING sequence H description BINDING => ECO:0000269|PubMed:8740360 source Swiss-Prot : SWS_FT_FI3 38) chain A residue 205 type BINDING sequence H description BINDING => ECO:0000269|PubMed:8740360 source Swiss-Prot : SWS_FT_FI3 39) chain A residue 211 type BINDING sequence H description BINDING => ECO:0000269|PubMed:8740360 source Swiss-Prot : SWS_FT_FI3 40) chain A residue 202 type ACT_SITE sequence E description source Swiss-Prot : SWS_FT_FI1 41) chain A residue 201 type catalytic sequence H description 591 source MCSA : MCSA1 42) chain A residue 202 type catalytic sequence E description 591 source MCSA : MCSA1 43) chain A residue 205 type catalytic sequence H description 591 source MCSA : MCSA1 44) chain A residue 211 type catalytic sequence H description 591 source MCSA : MCSA1 45) chain A residue 198-207 type prosite sequence VAAHEIGHSL description ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEIGHSL source prosite : PS00142

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