|
|
eF-site ID
|
1c2b-A |
|
PDB Code
|
1c2b |
|
Chain
|
A |
|
click to enlarge
|
|
|
Title
|
ELECTROPHORUS ELECTRICUS ACETYLCHOLINESTERASE |
|
Classification
|
HYDROLASE |
|
Compound
|
ACETYLCHOLINESTERASE |
|
Source
|
ORGANISM_COMMON: electric eel; ORGANISM_SCIENTIFIC: Electrophorus electricus; |
|
|
Sequence
|
A: |
DPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGS
RRFMPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTE
MWNPNRELSEDCLYLNVWTPYPRPASPTPVLIWIYGGGFY
SGAASLDVYDGRFLAQVEGAVLVSMNYRVGTFGFLALPGS
REAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESA
GAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEA
RRRATLLARLVGCPPGGAGGNDTELIACLRTRPAQDLVDH
EWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDL
QVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVR
IGVPQASDLAAEAVVLHYTDWLHPEDPTHLRDAMSAVVGD
HNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMG
VPHGYEIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFA
RTGDPNDPRDSKSPQWPPYTTAAQQYVSLNLKPLEVRRGL
RAQTCAFWNRFLPKLLSAT
|
|
|
Description
|
(1) |
ACETYLCHOLINESTERASE (E.C. 3.1.1.7)
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
190-205 |
| type |
prosite |
| sequence |
FGGDPMSVTLFGESAG
|
| description |
CARBOXYLESTERASE_B_1 Carboxylesterases type-B serine active site. FGGdpmsVtLfGeSAG
|
| source |
prosite : PS00122
|
|
|
2)
|
chain |
A |
| residue |
94-104 |
| type |
prosite |
| sequence |
EDCLYLNVWTP
|
| description |
CARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYLNVWtP
|
| source |
prosite : PS00941
|
|
|
3)
|
chain |
A |
| residue |
203 |
| type |
ACT_SITE |
| sequence |
S
|
| description |
Acyl-ester intermediate
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
A |
| residue |
334 |
| type |
ACT_SITE |
| sequence |
E
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
A |
| residue |
447 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
6)
|
chain |
A |
| residue |
265 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
7)
|
chain |
A |
| residue |
350 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
8)
|
chain |
A |
| residue |
464 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
|