eF-site ID 1bxs-B PDB Code 1bxs Chain B click to enlarge Title SHEEP LIVER CLASS 1 ALDEHYDE DEHYDROGENASE WITH NAD BOUND Classification OXIDOREDUCTASE Compound ALDEHYDE DEHYDROGENASE Source ORGANISM_COMMON: sheep; ORGANISM_SCIENTIFIC: Ovis aries; Sequence B:  DVPAPLTNLQFKYTKIFINNEWHSSVSGKKFPVFNPATEE KLCEVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGR LLNKLADLIERDRLLLATMEAMNGGKLFSNAYLMDLGGCI KTLRYCAGWADKIQGRTIPMDGNFFTYTRSEPVGVCGQII PWNFPLLMFLWKIGPALSCGNTVVVKPAEQTPLTALHMGS LIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGS TEVGKLIKEAAGKSNLKRVSLELGGKSPCIVFADADLDNA VEFAHQGVFYHQGQCCIAASRLFVEESIYDEFVRRSVERA KKYVLGNPLTPGVSQGPQIDKEQYEKILDLIESGKKEGAK LECGGGPWGNKGYFIQPTVFSDVTDDMRIAKEEIFGPVQQ IMKFKSLDDVIKRANNTFYGLSAGIFTNDIDKAITVSSAL QSGTVWVNCYSVVSAQCPFGGFKMSGNGRELGEYGFHEYT EVKTVTIKISQKNS Description Functional site 1) chain B residue 165 type sequence I description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 2) chain B residue 166 type sequence I description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 3) chain B residue 167 type sequence P description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 4) chain B residue 168 type sequence W description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 5) chain B residue 169 type sequence N description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 6) chain B residue 192 type sequence K description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 7) chain B residue 194 type sequence A description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 8) chain B residue 195 type sequence E description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 9) chain B residue 225 type sequence G description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 10) chain B residue 226 type sequence P description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 11) chain B residue 229 type sequence G description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 12) chain B residue 230 type sequence A description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 13) chain B residue 243 type sequence F description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 14) chain B residue 245 type sequence G description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 15) chain B residue 246 type sequence S description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 16) chain B residue 249 type sequence V description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 17) chain B residue 253 type sequence I description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 18) chain B residue 269 type sequence L description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 19) chain B residue 270 type sequence G description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 20) chain B residue 302 type sequence C description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 21) chain B residue 349 type sequence Q description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 22) chain B residue 352 type sequence K description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 23) chain B residue 399 type sequence E description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 24) chain B residue 401 type sequence F description BINDING SITE FOR RESIDUE NAD B 550 source : AC2 25) chain B residue 268 type ACT_SITE sequence E description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10007, ECO:0000255|PROSITE-ProRule:PRU10008 source Swiss-Prot : SWS_FT_FI1 26) chain B residue 336 type MOD_RES sequence T description Phosphothreonine => ECO:0000250|UniProtKB:P00352 source Swiss-Prot : SWS_FT_FI8 27) chain B residue 412 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P00352 source Swiss-Prot : SWS_FT_FI9 28) chain B residue 169 type SITE sequence N description Transition state stabilizer => ECO:0000250|UniProtKB:P20000 source Swiss-Prot : SWS_FT_FI5 29) chain B residue 127 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P00352 source Swiss-Prot : SWS_FT_FI7 30) chain B residue 251 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P00352 source Swiss-Prot : SWS_FT_FI7 31) chain B residue 352 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P00352 source Swiss-Prot : SWS_FT_FI7 32) chain B residue 366 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P00352 source Swiss-Prot : SWS_FT_FI7 33) chain B residue 409 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P00352 source Swiss-Prot : SWS_FT_FI7 34) chain B residue 418 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P00352 source Swiss-Prot : SWS_FT_FI7 35) chain B residue 494 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P00352 source Swiss-Prot : SWS_FT_FI7 36) chain B residue 90 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P00352 source Swiss-Prot : SWS_FT_FI7 37) chain B residue 302 type ACT_SITE sequence C description Nucleophile => ECO:0000303|PubMed:9862807 source Swiss-Prot : SWS_FT_FI2 38) chain B residue 245 type BINDING sequence G description BINDING => ECO:0000269|PubMed:26373694, ECO:0000269|PubMed:9862807, ECO:0007744|PDB:1BXS, ECO:0007744|PDB:5AC0 source Swiss-Prot : SWS_FT_FI3 39) chain B residue 348 type BINDING sequence E description BINDING => ECO:0000269|PubMed:26373694, ECO:0000269|PubMed:9862807, ECO:0007744|PDB:1BXS, ECO:0007744|PDB:5AC0 source Swiss-Prot : SWS_FT_FI3 40) chain B residue 399 type BINDING sequence E description BINDING => ECO:0000269|PubMed:26373694, ECO:0000269|PubMed:9862807, ECO:0007744|PDB:1BXS, ECO:0007744|PDB:5AC0 source Swiss-Prot : SWS_FT_FI3 41) chain B residue 166 type BINDING sequence I description BINDING => ECO:0000269|PubMed:26373694, ECO:0000269|PubMed:9862807, ECO:0007744|PDB:1BXS, ECO:0007744|PDB:5AC0 source Swiss-Prot : SWS_FT_FI3 42) chain B residue 192 type BINDING sequence K description BINDING => ECO:0000269|PubMed:26373694, ECO:0000269|PubMed:9862807, ECO:0007744|PDB:1BXS, ECO:0007744|PDB:5AC0 source Swiss-Prot : SWS_FT_FI3 43) chain B residue 225 type BINDING sequence G description BINDING => ECO:0000269|PubMed:26373694, ECO:0000269|PubMed:9862807, ECO:0007744|PDB:1BXS, ECO:0007744|PDB:5AC0 source Swiss-Prot : SWS_FT_FI3 44) chain B residue 268 type BINDING sequence E description BINDING => ECO:0000269|PubMed:26373694, ECO:0007744|PDB:5AC0 source Swiss-Prot : SWS_FT_FI4

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