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eF-site ID
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1bxo-A |
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PDB Code
|
1bxo |
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Chain
|
A |
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click to enlarge
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Title
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ACID PROTEINASE (PENICILLOPEPSIN) (E.C.3.4.23.20) COMPLEX WITH PHOSPHONATE INHIBITOR: METHYL CYCLO[(2S)-2-[[(1R)-1-(N-(L-N-(3-METHYLBUTANOYL)VALYL-L-ASPARTYL)AMINO)-3-METHYLBUT YL] HYDROXYPHOSPHINYLOXY]-3-(3-AMINOMETHYL) PHENYLPROPANOATE |
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Classification
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HYDROLASE |
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Compound
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PROTEIN (PENICILLOPEPSIN) |
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Source
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ORGANISM_SCIENTIFIC: Penicillium janthinellum; |
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Sequence
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A: |
AASGVATNTPTANDEEYITPVTIGGTTLNLNFDTGSADLW
VFSTELPASQQSGHSVYNPSATGKELSGYTWSISYGDGSS
ASGNVFTDSVTVGGVTAHGQAVQAAQQISAQFQQDTNNDG
LLGLAFSSINTVQPQSQTTFFDTVKSSLAQPLFAVALKHQ
QPGVYDFGFIDSSKYTGSLTYTGVDNSQGFWSFNVDSYTA
GSQSGDGFSGIADTGTTLLLLDDSVVSQYYSQVSGAQQDS
NAGGYVFDCSTNLPDFSVSISGYTATVPGSLINYGPSGDG
STCLGGIQSNSGIGFSIFGDIFLKSQYVVFDSDGPQLGFA
PQA
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Description
|
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Functional site
|
|
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1)
|
chain |
A |
| residue |
33 |
| type |
|
| sequence |
D
|
| description |
CATALYTIC RESIDUES
|
| source |
: CIC
|
|
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2)
|
chain |
A |
| residue |
213 |
| type |
|
| sequence |
D
|
| description |
CATALYTIC RESIDUES
|
| source |
: CIC
|
|
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3)
|
chain |
A |
| residue |
33 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01103, ECO:0000269|PubMed:5475460
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
A |
| residue |
213 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01103, ECO:0000269|PubMed:5475460
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
A |
| residue |
30-41 |
| type |
prosite |
| sequence |
LNFDTGSADLWV
|
| description |
ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LNFDTGSADLWV
|
| source |
prosite : PS00141
|
|
|
6)
|
chain |
A |
| residue |
210-221 |
| type |
prosite |
| sequence |
GIADTGTTLLLL
|
| description |
ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LNFDTGSADLWV
|
| source |
prosite : PS00141
|
|
|
7)
|
chain |
A |
| residue |
3 |
| type |
CARBOHYD |
| sequence |
S
|
| description |
O-linked (Man...) serine => ECO:0000269|PubMed:9836576, ECO:0000269|DOI:10.1021/ja973714r
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
A |
| residue |
7 |
| type |
CARBOHYD |
| sequence |
T
|
| description |
O-linked (Man...) threonine => ECO:0000269|PubMed:9836576, ECO:0000269|DOI:10.1021/ja973714r
|
| source |
Swiss-Prot : SWS_FT_FI3
|
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