eF-site ID 1bra-A PDB Code 1bra Chain A click to enlarge Title RELOCATING A NEGATIVE CHARGE IN THE BINDING POCKET OF TRYPSIN Classification PROTEINASE/INHIBITOR Compound TRYPSIN Source null (TRY2_RAT) Sequence A:  IVGGYTCQENSVPYQVSLNSGYHFCGGSLINDQWVVSAAH CYKSRIQVRLGEHNINVLEGNEQFVNAAKIIKHPNFDRKT LNNDIMLIKLSSPVKLNARVATVALPSSCAPAGTQCLISG WGNTLSSGVNEPDLLQCLDAPLLPQADCEASYPGKITDNM VCVGFLEGGKGSCQGDSGGPVVCNGELQGIVSWGYGCALP DNPDVYTKVCNYVDWIQDTIAAN Description (1)  TRYPSIN (E.C.3.4.21.4) VARIANT (D189G,G226D) COMPLEXED WITH BENZAMIDINE Functional site 1) chain A residue 57 type sequence H description CATALYTIC TRIAD RESIDUES, CONSERVED IN ALL SERINE PROTEASES OF THE TRYPSIN AND SUBTILISIN STRUCTURAL CLASSES source : CAT 2) chain A residue 102 type sequence D description CATALYTIC TRIAD RESIDUES, CONSERVED IN ALL SERINE PROTEASES OF THE TRYPSIN AND SUBTILISIN STRUCTURAL CLASSES source : CAT 3) chain A residue 195 type sequence S description CATALYTIC TRIAD RESIDUES, CONSERVED IN ALL SERINE PROTEASES OF THE TRYPSIN AND SUBTILISIN STRUCTURAL CLASSES source : CAT 4) chain A residue 70 type sequence E description BINDING SITE FOR RESIDUE CA A 302 source : AC1 5) chain A residue 72 type sequence N description BINDING SITE FOR RESIDUE CA A 302 source : AC1 6) chain A residue 75 type sequence V description BINDING SITE FOR RESIDUE CA A 302 source : AC1 7) chain A residue 77 type sequence E description BINDING SITE FOR RESIDUE CA A 302 source : AC1 8) chain A residue 80 type sequence E description BINDING SITE FOR RESIDUE CA A 302 source : AC1 9) chain A residue 190 type sequence S description BINDING SITE FOR RESIDUE BEN A 246 source : AC2 10) chain A residue 192 type sequence Q description BINDING SITE FOR RESIDUE BEN A 246 source : AC2 11) chain A residue 195 type sequence S description BINDING SITE FOR RESIDUE BEN A 246 source : AC2 12) chain A residue 213 type sequence V description BINDING SITE FOR RESIDUE BEN A 246 source : AC2 13) chain A residue 214 type sequence S description BINDING SITE FOR RESIDUE BEN A 246 source : AC2 14) chain A residue 216 type sequence G description BINDING SITE FOR RESIDUE BEN A 246 source : AC2 15) chain A residue 219 type sequence G description BINDING SITE FOR RESIDUE BEN A 246 source : AC2 16) chain A residue 226 type sequence D description BINDING SITE FOR RESIDUE BEN A 246 source : AC2 17) chain A residue 53-58 type prosite sequence VSAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC source prosite : PS00134 18) chain A residue 189-200 type prosite sequence GSCQGDSGGPVV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. GScqGDSGGPVV source prosite : PS00135 19) chain A residue 57 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI1 20) chain A residue 102 type ACT_SITE sequence D description Charge relay system source Swiss-Prot : SWS_FT_FI1 21) chain A residue 195 type ACT_SITE sequence S description Charge relay system source Swiss-Prot : SWS_FT_FI1 22) chain A residue 75 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 23) chain A residue 80 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 24) chain A residue 70 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 25) chain A residue 72 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 26) chain A residue 189 type SITE sequence G description Required for specificity => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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