eF-site ID 1bp3-AB PDB Code 1bp3 Chain A, B click to enlarge Title THE XRAY STRUCTURE OF A GROWTH HORMONE-PROLACTIN RECEPTOR COMPLEX Classification HORMONE/GROWTH FACTOR Compound PROTEIN (GROWTH HORMONE) Source Homo sapiens (Human) (PRLR_HUMAN) Sequence A:  FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQ KYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISL LLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEER IQTLMGRLEDGSPRTGQIFKQTYSKFDTDDALLKNYGLLY CFRKDMDKVETFLRIVQCRSVEGSCG B:  LPPGKPEIFKCRSPNKETFTCWWRPGTDGTNYSLTYHREG ETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNS SFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYLWIKW SPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEF KILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPS Description Functional site 1) chain A residue 18 type sequence H description ZINC BINDING SITE BETWEEN HGH AND PROLACTIN RECEPTOR. source : ZNA 2) chain A residue 174 type sequence E description ZINC BINDING SITE BETWEEN HGH AND PROLACTIN RECEPTOR. source : ZNA 3) chain B residue 387 type sequence D description ZINC BINDING SITE BETWEEN HGH AND PROLACTIN RECEPTOR. source : ZNA 4) chain B residue 388 type sequence H description ZINC BINDING SITE BETWEEN HGH AND PROLACTIN RECEPTOR. source : ZNA 5) chain A residue 18 type sequence H description BINDING SITE FOR RESIDUE ZN A 500 source : AC1 6) chain A residue 174 type sequence E description BINDING SITE FOR RESIDUE ZN A 500 source : AC1 7) chain B residue 387 type sequence D description BINDING SITE FOR RESIDUE ZN A 500 source : AC1 8) chain B residue 388 type sequence H description BINDING SITE FOR RESIDUE ZN A 500 source : AC1 9) chain A residue 53-86 type prosite sequence CFSESIPTPSNREETQQKSNLELLRISLLLIQSW description SOMATOTROPIN_1 Somatotropin, prolactin and related hormones signature 1. CfSesIpTPsnreeTqqksnleLlrisllLiqSW source prosite : PS00266 10) chain A residue 165-182 type prosite sequence CFRKDMDKVETFLRIVQC description SOMATOTROPIN_2 Somatotropin, prolactin and related hormones signature 2. CFRkDMdKVEtFlrIvqC source prosite : PS00338 11) chain B residue 323-400 type prosite sequence LWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAG QQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFI description HEMATOPO_REC_L_F1 Long hematopoietin receptor, single chain family signature. LwIkWspptlidlktgwftllYEIrlkpekaaeweihfagqqtefkils..LhpgqkylvqvRcKpdhgy....WsaWspatfI source prosite : PS01352 12) chain A residue 174 type TOPO_DOM sequence E description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 13) chain B residue 387 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 14) chain B residue 388 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 15) chain B residue 235 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 16) chain B residue 280 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI3

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