eF-site ID 1bmk-A PDB Code 1bmk Chain A click to enlarge Title THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB218655 Classification TRANSFERASE Compound PROTEIN (MAP KINASE P38) Source Homo sapiens (Human) (MK14_HUMAN) Sequence A:  ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFD TKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV IGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLT DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE LKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQT VDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPG AELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVD LLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPY DQSFESRDLLIDEWKSLTYDEVISFVPPPLD Description Functional site 1) chain A residue 30 type sequence V description BINDING SITE FOR RESIDUE SB5 A 800 source : AC1 2) chain A residue 31 type sequence G description BINDING SITE FOR RESIDUE SB5 A 800 source : AC1 3) chain A residue 32 type sequence S description BINDING SITE FOR RESIDUE SB5 A 800 source : AC1 4) chain A residue 35 type sequence Y description BINDING SITE FOR RESIDUE SB5 A 800 source : AC1 5) chain A residue 38 type sequence V description BINDING SITE FOR RESIDUE SB5 A 800 source : AC1 6) chain A residue 51 type sequence A description BINDING SITE FOR RESIDUE SB5 A 800 source : AC1 7) chain A residue 53 type sequence K description BINDING SITE FOR RESIDUE SB5 A 800 source : AC1 8) chain A residue 104 type sequence L description BINDING SITE FOR RESIDUE SB5 A 800 source : AC1 9) chain A residue 105 type sequence V description BINDING SITE FOR RESIDUE SB5 A 800 source : AC1 10) chain A residue 106 type sequence T description BINDING SITE FOR RESIDUE SB5 A 800 source : AC1 11) chain A residue 107 type sequence H description BINDING SITE FOR RESIDUE SB5 A 800 source : AC1 12) chain A residue 108 type sequence L description BINDING SITE FOR RESIDUE SB5 A 800 source : AC1 13) chain A residue 109 type sequence M description BINDING SITE FOR RESIDUE SB5 A 800 source : AC1 14) chain A residue 30-54 type prosite sequence VGSGAYGSVCAAFDTKTGHRVAVKK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCaAfdtktghrv.........AVKK source prosite : PS00107 15) chain A residue 59-162 type prosite sequence FQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEE FNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGL KYIHSADIIHRDLKPSNLAVNEDC description MAPK MAP kinase signature. FqsiihakrtyRElrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfliyqilrglkyihsadiih.........RDlKpsnlavnedC source prosite : PS01351 16) chain A residue 168 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 17) chain A residue 30 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 18) chain A residue 53 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 19) chain A residue 16 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:18691976 source Swiss-Prot : SWS_FT_FI4 20) chain A residue 53 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:21444723 source Swiss-Prot : SWS_FT_FI5 21) chain A residue 152 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:21444723 source Swiss-Prot : SWS_FT_FI5 22) chain A residue 180 type MOD_RES sequence T description Phosphothreonine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis => ECO:0000269|PubMed:7535770, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI6 23) chain A residue 182 type MOD_RES sequence Y description Phosphotyrosine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis => ECO:0000269|PubMed:7535770, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI7 24) chain A residue 263 type MOD_RES sequence A description Phosphothreonine => ECO:0007744|PubMed:17525332 source Swiss-Prot : SWS_FT_FI8 25) chain A residue 323 type MOD_RES sequence Y description Phosphotyrosine; by ZAP70 => ECO:0000269|PubMed:15735648 source Swiss-Prot : SWS_FT_FI9

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