eF-site ID 1bmk-A
PDB Code 1bmk
Chain A

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Title THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB218655
Classification TRANSFERASE
Compound PROTEIN (MAP KINASE P38)
Source Homo sapiens (Human) (MK14_HUMAN)
Sequence A:  ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFD
TKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV
IGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLT
DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE
LKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQT
VDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPG
AELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVD
LLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPY
DQSFESRDLLIDEWKSLTYDEVISFVPPPLD
Description


Functional site

1) chain A
residue 30
type
sequence V
description BINDING SITE FOR RESIDUE SB5 A 800
source : AC1

2) chain A
residue 31
type
sequence G
description BINDING SITE FOR RESIDUE SB5 A 800
source : AC1

3) chain A
residue 32
type
sequence S
description BINDING SITE FOR RESIDUE SB5 A 800
source : AC1

4) chain A
residue 35
type
sequence Y
description BINDING SITE FOR RESIDUE SB5 A 800
source : AC1

5) chain A
residue 38
type
sequence V
description BINDING SITE FOR RESIDUE SB5 A 800
source : AC1

6) chain A
residue 51
type
sequence A
description BINDING SITE FOR RESIDUE SB5 A 800
source : AC1

7) chain A
residue 53
type
sequence K
description BINDING SITE FOR RESIDUE SB5 A 800
source : AC1

8) chain A
residue 104
type
sequence L
description BINDING SITE FOR RESIDUE SB5 A 800
source : AC1

9) chain A
residue 105
type
sequence V
description BINDING SITE FOR RESIDUE SB5 A 800
source : AC1

10) chain A
residue 106
type
sequence T
description BINDING SITE FOR RESIDUE SB5 A 800
source : AC1

11) chain A
residue 107
type
sequence H
description BINDING SITE FOR RESIDUE SB5 A 800
source : AC1

12) chain A
residue 108
type
sequence L
description BINDING SITE FOR RESIDUE SB5 A 800
source : AC1

13) chain A
residue 109
type
sequence M
description BINDING SITE FOR RESIDUE SB5 A 800
source : AC1

14) chain A
residue 30-54
type prosite
sequence VGSGAYGSVCAAFDTKTGHRVAVKK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCaAfdtktghrv.........AVKK
source prosite : PS00107

15) chain A
residue 59-162
type prosite
sequence FQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEE
FNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGL
KYIHSADIIHRDLKPSNLAVNEDC
description MAPK MAP kinase signature. FqsiihakrtyRElrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfliyqilrglkyihsadiih.........RDlKpsnlavnedC
source prosite : PS01351

16) chain A
residue 168
type ACT_SITE
sequence D
description Proton acceptor
source Swiss-Prot : SWS_FT_FI1

17) chain A
residue 30
type BINDING
sequence V
description
source Swiss-Prot : SWS_FT_FI2

18) chain A
residue 53
type BINDING
sequence K
description
source Swiss-Prot : SWS_FT_FI2

19) chain A
residue 16
type MOD_RES
sequence T
description Phosphothreonine => ECO:0007744|PubMed:18691976
source Swiss-Prot : SWS_FT_FI4

20) chain A
residue 53
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000269|PubMed:21444723
source Swiss-Prot : SWS_FT_FI5

21) chain A
residue 152
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000269|PubMed:21444723
source Swiss-Prot : SWS_FT_FI5

22) chain A
residue 180
type MOD_RES
sequence T
description Phosphothreonine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis => ECO:0000269|PubMed:7535770, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI6

23) chain A
residue 182
type MOD_RES
sequence Y
description Phosphotyrosine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis => ECO:0000269|PubMed:7535770, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI7

24) chain A
residue 263
type MOD_RES
sequence A
description Phosphothreonine => ECO:0007744|PubMed:17525332
source Swiss-Prot : SWS_FT_FI8

25) chain A
residue 323
type MOD_RES
sequence Y
description Phosphotyrosine; by ZAP70 => ECO:0000269|PubMed:15735648
source Swiss-Prot : SWS_FT_FI9


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