eF-site ID 1bkd-RS PDB Code 1bkd Chain R, S click to enlarge Title COMPLEX OF HUMAN H-RAS WITH HUMAN SOS-1 Classification COMPLEX(ONCOGENE PROTEIN/EXCHANGE FACTOR) Compound H-RAS Source Homo sapiens (Human) (SOS1_HUMAN) Sequence R:  MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSY RKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLC VFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLV REIRQH S:  RLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIERL TYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEP RFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRME EFIGTVRGKAMKKWVESITKIIQRKKITFQSSPPTVEWHI SRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELV GSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENL EERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYR LDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPP CVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVA EITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEF TDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSN Description Functional site 1) chain R residue 13 type BINDING sequence G description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 2) chain R residue 29 type BINDING sequence V description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 3) chain R residue 59 type BINDING sequence A description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 4) chain R residue 116 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 5) chain R residue 145 type BINDING sequence S description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 6) chain S residue 927-960 type prosite sequence VPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK description RASGEF Ras Guanine-nucleotide exchange factors domain signature. VPFfGiyLtNIlkteegnpevlkrhgkel.................INFsK source prosite : PS00720 7) chain R residue 1 type MOD_RES sequence M description N-acetylmethionine; in GTPase HRas; alternate => ECO:0000269|Ref.12 source Swiss-Prot : SWS_FT_FI2 8) chain R residue 2 type MOD_RES sequence T description N-acetylthreonine; in GTPase HRas, N-terminally processed => ECO:0000269|Ref.12 source Swiss-Prot : SWS_FT_FI3 9) chain R residue 118 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000269|PubMed:9020151 source Swiss-Prot : SWS_FT_FI4 10) chain R residue 35 type CARBOHYD sequence T description (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:8626575, ECO:0000269|PubMed:8626586, ECO:0000269|PubMed:9632667 source Swiss-Prot : SWS_FT_FI5

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