eF-site ID 1bim-B PDB Code 1bim Chain B click to enlarge Title CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS Classification HYDROLASE/HYDROLASE INHIBITOR Compound Renin Source (RENI_HUMAN) Sequence B:  GNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSN VWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRY STGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAE FDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYN RDSSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKG VSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALG AKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQ ESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEF DRRNNRIGFALAR Description Functional site 1) chain B residue 12 type sequence T description BINDING SITE FOR RESIDUE 0QB B 391 source : AC2 2) chain B residue 13 type sequence Q description BINDING SITE FOR RESIDUE 0QB B 391 source : AC2 3) chain B residue 32 type sequence D description BINDING SITE FOR RESIDUE 0QB B 391 source : AC2 4) chain B residue 75 type sequence Y description BINDING SITE FOR RESIDUE 0QB B 391 source : AC2 5) chain B residue 76 type sequence S description BINDING SITE FOR RESIDUE 0QB B 391 source : AC2 6) chain B residue 77 type sequence T description BINDING SITE FOR RESIDUE 0QB B 391 source : AC2 7) chain B residue 112 type sequence F description BINDING SITE FOR RESIDUE 0QB B 391 source : AC2 8) chain B residue 114 type sequence L description BINDING SITE FOR RESIDUE 0QB B 391 source : AC2 9) chain B residue 213 type sequence L description BINDING SITE FOR RESIDUE 0QB B 391 source : AC2 10) chain B residue 215 type sequence D description BINDING SITE FOR RESIDUE 0QB B 391 source : AC2 11) chain B residue 217 type sequence G description BINDING SITE FOR RESIDUE 0QB B 391 source : AC2 12) chain B residue 218 type sequence A description BINDING SITE FOR RESIDUE 0QB B 391 source : AC2 13) chain B residue 219 type sequence S description BINDING SITE FOR RESIDUE 0QB B 391 source : AC2 14) chain B residue 220 type sequence Y description BINDING SITE FOR RESIDUE 0QB B 391 source : AC2 15) chain B residue 222 type sequence S description BINDING SITE FOR RESIDUE 0QB B 391 source : AC2 16) chain B residue 291 type sequence I description BINDING SITE FOR RESIDUE 0QB B 391 source : AC2 17) chain B residue 32 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 18) chain B residue 215 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 19) chain B residue -1 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2 20) chain B residue 67 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2

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