eF-site ID 1bg3-AB PDB Code 1bg3 Chain A, B click to enlarge Title RAT BRAIN HEXOKINASE TYPE I COMPLEX WITH GLUCOSE AND INHIBITOR GLUCOSE-6-PHOSPHATE Classification HEXOKINASE Compound HEXOKINASE Source ORGANISM_COMMON: Norway rat; ORGANISM_SCIENTIFIC: Rattus norvegicus; Sequence A:  MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDEILIDIL TRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDF IALDLGGSSFRILRVQVNVSMESEIYDTPENIVHGSGTQL FDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEA VLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAV VNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHID LVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSL NPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITP ELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLGVEPSDV DCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRL RTTVGVDGSLYKMHPQYSRRFHKTLRRLVPDSDVRFLLSE SGTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLSKQTLME VKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHG DFLALDLGGTNFRVLLVKIRSRTVEMHNKIYSIPLEIMQG TGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQT NLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDL DVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEE MKNVEMVEGNQGQMCINMEWGAFGDNGCLDDIRTDFDKVV DEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFR GQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGL NSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENR GLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVS FLLSEDGSGKGAALITAVGVRL B:  MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDEILIDIL TRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDF IALDLGGSSFRILRVQVNVSMESEIYDTPENIVHGSGTQL FDHVADCLGDFMEKKDKKLPVGFTFSFPCRQSKIDEAVLI TWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVND TVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVE GDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPG KQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELL TRGKFNTSDVSAIEKDKEGIQNAKEILTRLGVEPSDVDCV SVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTT VGVDGSLYKMHPQYSRRFHKTLRRLVPDSDVRFLLSESGT GKGAAMVTAVAYRLAEQHRQIEETLAHFRLSKQTLMEVKK RLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFL ALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQG TGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQT NLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDL DVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEE MKNVEMVEGNQGQMCINMEWGAFGDNGCLDDIRTDFDKVV DEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFR GQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGL NSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENR GLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVS FLLSEDGSGKGAALITAVGVRL Description Functional site 1) chain A residue 150-175 type prosite sequence VGFTFSFPCRQSKIDEAVLITWTKRF description HEXOKINASE_1 Hexokinase domain signature. VGFTFSFPcrqskIDeavLitWTKrF source prosite : PS00378 2) chain A residue 598-623 type prosite sequence LGFTFSFPCHQTNLDCGILISWTKGF description HEXOKINASE_1 Hexokinase domain signature. VGFTFSFPcrqskIDeavLitWTKrF source prosite : PS00378 3) chain A residue 30 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P19367 source Swiss-Prot : SWS_FT_FI1 4) chain B residue 863 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:P19367 source Swiss-Prot : SWS_FT_FI1 5) chain A residue 425 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P19367 source Swiss-Prot : SWS_FT_FI1 6) chain A residue 747 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:P19367 source Swiss-Prot : SWS_FT_FI1 7) chain A residue 784 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:P19367 source Swiss-Prot : SWS_FT_FI1 8) chain A residue 863 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:P19367 source Swiss-Prot : SWS_FT_FI1 9) chain B residue 30 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P19367 source Swiss-Prot : SWS_FT_FI1 10) chain B residue 425 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P19367 source Swiss-Prot : SWS_FT_FI1 11) chain B residue 747 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:P19367 source Swiss-Prot : SWS_FT_FI1 12) chain B residue 784 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:P19367 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 84 type BINDING sequence D description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 14) chain A residue 413 type BINDING sequence D description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 449 type BINDING sequence T description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 532 type BINDING sequence D description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 17) chain A residue 603 type BINDING sequence S description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 620 type BINDING sequence T description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 656 type BINDING sequence N description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 657 type BINDING sequence D description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 680 type BINDING sequence T description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 22) chain A residue 683 type BINDING sequence N description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 708 type BINDING sequence E description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 24) chain A residue 155 type BINDING sequence S description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 742 type BINDING sequence E description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 861 type BINDING sequence D description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 27) chain A residue 897 type BINDING sequence S description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 28) chain B residue 84 type BINDING sequence D description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 29) chain B residue 155 type BINDING sequence S description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 30) chain B residue 172 type BINDING sequence T description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 31) chain B residue 208 type BINDING sequence N description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 32) chain B residue 209 type BINDING sequence D description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 33) chain B residue 232 type BINDING sequence T description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 34) chain B residue 235 type BINDING sequence N description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 35) chain A residue 172 type BINDING sequence T description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 36) chain B residue 260 type BINDING sequence E description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 37) chain B residue 291 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 38) chain B residue 413 type BINDING sequence D description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 39) chain B residue 449 type BINDING sequence T description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 40) chain B residue 532 type BINDING sequence D description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 41) chain B residue 603 type BINDING sequence S description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 42) chain B residue 620 type BINDING sequence T description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 43) chain B residue 656 type BINDING sequence N description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 44) chain B residue 657 type BINDING sequence D description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 45) chain B residue 680 type BINDING sequence T description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 46) chain A residue 208 type BINDING sequence N description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 47) chain B residue 683 type BINDING sequence N description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 48) chain B residue 708 type BINDING sequence E description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 49) chain B residue 742 type BINDING sequence E description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 50) chain B residue 861 type BINDING sequence D description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 51) chain B residue 897 type BINDING sequence S description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 52) chain A residue 209 type BINDING sequence D description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 53) chain A residue 232 type BINDING sequence T description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 54) chain A residue 235 type BINDING sequence N description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 55) chain A residue 260 type BINDING sequence E description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 56) chain A residue 291 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9665168, ECO:0007744|PDB:1BG3 source Swiss-Prot : SWS_FT_FI2 57) chain A residue 1 type MOD_RES sequence M description N-acetylmethionine => ECO:0000250|UniProtKB:P19367 source Swiss-Prot : SWS_FT_FI3 58) chain B residue 1 type MOD_RES sequence M description N-acetylmethionine => ECO:0000250|UniProtKB:P19367 source Swiss-Prot : SWS_FT_FI3 59) chain A residue 337 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI4 60) chain B residue 337 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI4

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