eF-site ID 1bez-A PDB Code 1bez Chain A click to enlarge Title HALOALKANE DEHALOGENASE MUTANT WITH TRP 175 REPLACED BY TYR AT PH 5 Classification DEHALOGENASE Compound HALOALKANE DEHALOGENASE Source Xanthobacter autotrophicus (DHLA_XANAU) Sequence A:  MVNAIRTPDQRFSNLDQYPFSPNYLDDLPGYPGLRAHYLD EGNSDAEDVFLCLHGEPTWSYLYRKMIPVFAESGARVIAP DFFGFGKSDKPVDEEDYTFEFHRNFLLALIERLDLRNITL VVQDWGGFLGLTLPMADPSRFKRLIIMNACLMTDPVTQPA FSAFVTQPADGFTAYKYDLVTPSDLRLDQFMKRWAPTLTE AEASAYAAPFPDTSYQAGVRKFPKMVAQRDQACIDISTEA ISFWQNDWNGQTFMAIGMKDKLLGPDVMYPMKALINGCPE PLEIADAGHFVQEFGEQVAREALKHFAETE Description Functional site 1) chain A residue 124 type sequence D description BINDING SITE FOR RESIDUE ACY A 401 source : AC1 2) chain A residue 125 type sequence W description BINDING SITE FOR RESIDUE ACY A 401 source : AC1 3) chain A residue 128 type sequence F description BINDING SITE FOR RESIDUE ACY A 401 source : AC1 4) chain A residue 175 type sequence Y description BINDING SITE FOR RESIDUE ACY A 401 source : AC1 5) chain A residue 223 type sequence P description BINDING SITE FOR RESIDUE ACY A 401 source : AC1 6) chain A residue 226 type sequence V description BINDING SITE FOR RESIDUE ACY A 401 source : AC1 7) chain A residue 4 type sequence A description BINDING SITE FOR RESIDUE ACY A 402 source : AC2 8) chain A residue 6 type sequence R description BINDING SITE FOR RESIDUE ACY A 402 source : AC2 9) chain A residue 33 type sequence G description BINDING SITE FOR RESIDUE ACY A 402 source : AC2 10) chain A residue 89 type sequence D description BINDING SITE FOR RESIDUE ACY A 402 source : AC2 11) chain A residue 125 type BINDING sequence W description BINDING => ECO:0000269|PubMed:10393294, ECO:0000269|PubMed:8515812 source Swiss-Prot : SWS_FT_FI4 12) chain A residue 124 type ACT_SITE sequence D description Nucleophile source Swiss-Prot : SWS_FT_FI1 13) chain A residue 260 type ACT_SITE sequence D description Proton donor source Swiss-Prot : SWS_FT_FI2 14) chain A residue 289 type ACT_SITE sequence H description Proton acceptor source Swiss-Prot : SWS_FT_FI3 15) chain A residue 124 type catalytic sequence D description 415 source MCSA : MCSA1 16) chain A residue 125 type catalytic sequence W description 415 source MCSA : MCSA1 17) chain A residue 175 type catalytic sequence Y description 415 source MCSA : MCSA1 18) chain A residue 260 type catalytic sequence D description 415 source MCSA : MCSA1 19) chain A residue 289 type catalytic sequence H description 415 source MCSA : MCSA1 20) chain A residue 175 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10393294, ECO:0000269|PubMed:8515812, ECO:0007744|PDB:2DHD, ECO:0007744|PDB:2DHE source Swiss-Prot : SWS_FT_FI5

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