eF-site ID 1bdm-B PDB Code 1bdm Chain B click to enlarge Title THE STRUCTURE AT 1.8 ANGSTROMS RESOLUTION OF A SINGLE SITE MUTANT (T189I) OF MALATE DEHYDROGENASE FROM THERMUS FLAVUS WITH INCREASED ENZYMATIC ACTIVITY Classification OXIDOREDUCTASE(NAD(A)-CHOH(D)) Compound MALATE DEHYDROGENASE Source Thermus thermophilus (MDH_THETH) Sequence B:  MKAPVRVAVTGAAGQIGYSLLFRIAAGEMLGKDQPVILQL LEIPQAMKALEGVVMELEDCAFPLLAGLEATDDPDVAFKD ADYALLVGAAPRKAGMERRDLLQVNGKIFTEQGRALAEVA KKDVKVLVVGNPANTNALIAYKNAPGLNPRNFTAMTRLDH NRAKAQLAKKTGTGVDRIRRMTVWGNHSSIMFPDLFHAEV DGRPALELVDMEWYEKVFIPTVAQRGAAIIQARGASSAAS AANAAIEHIRDWALGTPEGDWVSMAVPSQGEYGIPEGIVY SFPVTAKDGAYRVVEGLEINEFARKRMEITAQELLDEMEQ VKALGLI Description Functional site 1) chain B residue 10 type sequence G description BINDING SITE FOR RESIDUE NAX B 334 source : AC2 2) chain B residue 13 type sequence G description BINDING SITE FOR RESIDUE NAX B 334 source : AC2 3) chain B residue 14 type sequence Q description BINDING SITE FOR RESIDUE NAX B 334 source : AC2 4) chain B residue 15 type sequence I description BINDING SITE FOR RESIDUE NAX B 334 source : AC2 5) chain B residue 41 type sequence E description BINDING SITE FOR RESIDUE NAX B 334 source : AC2 6) chain B residue 42 type sequence I description BINDING SITE FOR RESIDUE NAX B 334 source : AC2 7) chain B residue 86 type sequence V description BINDING SITE FOR RESIDUE NAX B 334 source : AC2 8) chain B residue 87 type sequence G description BINDING SITE FOR RESIDUE NAX B 334 source : AC2 9) chain B residue 88 type sequence A description BINDING SITE FOR RESIDUE NAX B 334 source : AC2 10) chain B residue 107 type sequence I description BINDING SITE FOR RESIDUE NAX B 334 source : AC2 11) chain B residue 111 type sequence Q description BINDING SITE FOR RESIDUE NAX B 334 source : AC2 12) chain B residue 128 type sequence V description BINDING SITE FOR RESIDUE NAX B 334 source : AC2 13) chain B residue 129 type sequence G description BINDING SITE FOR RESIDUE NAX B 334 source : AC2 14) chain B residue 130 type sequence N description BINDING SITE FOR RESIDUE NAX B 334 source : AC2 15) chain B residue 154 type sequence M description BINDING SITE FOR RESIDUE NAX B 334 source : AC2 16) chain B residue 186 type sequence H description BINDING SITE FOR RESIDUE NAX B 334 source : AC2 17) chain B residue 245 type sequence A description BINDING SITE FOR RESIDUE NAX B 334 source : AC2 18) chain B residue 186 type ACT_SITE sequence H description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_01517 source Swiss-Prot : SWS_FT_FI1 19) chain B residue 10 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01517, ECO:0000269|PubMed:16009341, ECO:0000269|PubMed:8471603 source Swiss-Prot : SWS_FT_FI2 20) chain B residue 128 type BINDING sequence V description BINDING => ECO:0000255|HAMAP-Rule:MF_01517, ECO:0000269|PubMed:16009341, ECO:0000269|PubMed:8471603 source Swiss-Prot : SWS_FT_FI2 21) chain B residue 161 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01517 source Swiss-Prot : SWS_FT_FI3 22) chain B residue 91 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01517 source Swiss-Prot : SWS_FT_FI3 23) chain B residue 97 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01517 source Swiss-Prot : SWS_FT_FI3 24) chain B residue 104 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_01517 source Swiss-Prot : SWS_FT_FI3 25) chain B residue 130 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_01517 source Swiss-Prot : SWS_FT_FI3 26) chain B residue 111 type BINDING sequence Q description BINDING => ECO:0000255|HAMAP-Rule:MF_01517, ECO:0000269|PubMed:16009341 source Swiss-Prot : SWS_FT_FI4

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