eF-site ID 1bda-B PDB Code 1bda Chain B click to enlarge Title CATALYTIC DOMAIN OF HUMAN SINGLE CHAIN TISSUE PLASMINOGEN ACTIVATOR IN COMPLEX WITH DANSYL-EGR-CMK (DANSYL-GLU-GLY-ARG CHLOROMETHYL KETONE) Classification HYDROLASE/HYDROLASE INHIBITOR Compound SINGLE CHAIN TISSUE TYPE PLASMINOGEN ACTIVATOR Source Homo sapiens (Human) (TPA_HUMAN) Sequence B:  TCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPG ERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYR VVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSS RCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSP FYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTR SGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGC GQKDVPGVYTKVTNYLDWIRDNMRP Description Functional site 1) chain B residue 133 type sequence W description BINDING SITE FOR RESIDUE 2Z0 A 245 source : AC1 2) chain B residue 163 type sequence Y description BINDING SITE FOR RESIDUE 2Z0 A 245 source : AC1 3) chain B residue 167 type sequence R description BINDING SITE FOR RESIDUE 2Z0 A 245 source : AC1 4) chain B residue 223 type sequence D description BINDING SITE FOR RESIDUE 2Z0 A 245 source : AC1 5) chain B residue 57 type sequence H description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 6) chain B residue 99 type sequence Y description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 7) chain B residue 174 type sequence R description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 8) chain B residue 189 type sequence D description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 9) chain B residue 190 type sequence A description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 10) chain B residue 192 type sequence Q description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 11) chain B residue 193 type sequence G description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 12) chain B residue 195 type sequence S description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 13) chain B residue 214 type sequence S description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 14) chain B residue 215 type sequence W description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 15) chain B residue 216 type sequence G description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 16) chain B residue 217 type sequence L description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 17) chain B residue 219 type sequence G description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 18) chain B residue 58 type catalytic sequence C description 798 source MCSA : MCSA2 19) chain B residue 103 type catalytic sequence I description 798 source MCSA : MCSA2 20) chain B residue 194 type catalytic sequence D description 798 source MCSA : MCSA2 21) chain B residue 196 type catalytic sequence G description 798 source MCSA : MCSA2 22) chain B residue 157 type SITE sequence E description Important for single-chain activity source Swiss-Prot : SWS_FT_FI2 23) chain B residue 195 type SITE sequence S description Important for single-chain activity source Swiss-Prot : SWS_FT_FI2 24) chain B residue 58 type ACT_SITE sequence C description Charge relay system => ECO:0000305|PubMed:8613982 source Swiss-Prot : SWS_FT_FI1 25) chain B residue 103 type ACT_SITE sequence I description Charge relay system => ECO:0000305|PubMed:8613982 source Swiss-Prot : SWS_FT_FI1 26) chain B residue 196 type ACT_SITE sequence G description Charge relay system => ECO:0000305|PubMed:8613982 source Swiss-Prot : SWS_FT_FI1 27) chain B residue 174 type CARBOHYD sequence R description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2513186 source Swiss-Prot : SWS_FT_FI3

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