eF-site ID 1bda-AB PDB Code 1bda Chain A, B click to enlarge Title CATALYTIC DOMAIN OF HUMAN SINGLE CHAIN TISSUE PLASMINOGEN ACTIVATOR IN COMPLEX WITH DANSYL-EGR-CMK (DANSYL-GLU-GLY-ARG CHLOROMETHYL KETONE) Classification HYDROLASE/HYDROLASE INHIBITOR Compound SINGLE CHAIN TISSUE TYPE PLASMINOGEN ACTIVATOR Source null (TPA_HUMAN) Sequence A:  TCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPG ERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYR VVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSS RCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSP FYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTR SGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGC GQKDVPGVYTKVTNYLDWIRDNMRP B:  TCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPG ERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYR VVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSS RCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSP FYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTR SGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGC GQKDVPGVYTKVTNYLDWIRDNMRP Description Functional site 1) chain A residue 57 type sequence H description BINDING SITE FOR RESIDUE 2Z0 A 245 source : AC1 2) chain A residue 99 type sequence Y description BINDING SITE FOR RESIDUE 2Z0 A 245 source : AC1 3) chain A residue 174 type sequence R description BINDING SITE FOR RESIDUE 2Z0 A 245 source : AC1 4) chain A residue 189 type sequence D description BINDING SITE FOR RESIDUE 2Z0 A 245 source : AC1 5) chain A residue 190 type sequence A description BINDING SITE FOR RESIDUE 2Z0 A 245 source : AC1 6) chain A residue 193 type sequence G description BINDING SITE FOR RESIDUE 2Z0 A 245 source : AC1 7) chain A residue 195 type sequence S description BINDING SITE FOR RESIDUE 2Z0 A 245 source : AC1 8) chain A residue 214 type sequence S description BINDING SITE FOR RESIDUE 2Z0 A 245 source : AC1 9) chain A residue 215 type sequence W description BINDING SITE FOR RESIDUE 2Z0 A 245 source : AC1 10) chain A residue 216 type sequence G description BINDING SITE FOR RESIDUE 2Z0 A 245 source : AC1 11) chain A residue 219 type sequence G description BINDING SITE FOR RESIDUE 2Z0 A 245 source : AC1 12) chain B residue 133 type sequence W description BINDING SITE FOR RESIDUE 2Z0 A 245 source : AC1 13) chain B residue 163 type sequence Y description BINDING SITE FOR RESIDUE 2Z0 A 245 source : AC1 14) chain B residue 167 type sequence R description BINDING SITE FOR RESIDUE 2Z0 A 245 source : AC1 15) chain B residue 223 type sequence D description BINDING SITE FOR RESIDUE 2Z0 A 245 source : AC1 16) chain A residue 133 type sequence W description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 17) chain A residue 163 type sequence Y description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 18) chain A residue 167 type sequence R description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 19) chain A residue 185 type sequence D description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 20) chain A residue 223 type sequence D description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 21) chain B residue 57 type sequence H description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 22) chain B residue 99 type sequence Y description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 23) chain B residue 174 type sequence R description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 24) chain B residue 189 type sequence D description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 25) chain B residue 190 type sequence A description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 26) chain B residue 192 type sequence Q description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 27) chain B residue 193 type sequence G description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 28) chain B residue 195 type sequence S description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 29) chain B residue 214 type sequence S description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 30) chain B residue 215 type sequence W description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 31) chain B residue 216 type sequence G description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 32) chain B residue 217 type sequence L description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 33) chain B residue 219 type sequence G description BINDING SITE FOR RESIDUE 2Z0 B 245 source : AC2 34) chain A residue 196 type catalytic sequence G description 798 source MCSA : MCSA1 35) chain A residue 58 type catalytic sequence C description 798 source MCSA : MCSA1 36) chain A residue 103 type catalytic sequence I description 798 source MCSA : MCSA1 37) chain A residue 194 type catalytic sequence D description 798 source MCSA : MCSA1 38) chain B residue 196 type catalytic sequence G description 798 source MCSA : MCSA2 39) chain B residue 58 type catalytic sequence C description 798 source MCSA : MCSA2 40) chain B residue 103 type catalytic sequence I description 798 source MCSA : MCSA2 41) chain B residue 194 type catalytic sequence D description 798 source MCSA : MCSA2 42) chain A residue 58 type ACT_SITE sequence C description Charge relay system => ECO:0000305|PubMed:8613982 source Swiss-Prot : SWS_FT_FI1 43) chain A residue 103 type ACT_SITE sequence I description Charge relay system => ECO:0000305|PubMed:8613982 source Swiss-Prot : SWS_FT_FI1 44) chain A residue 196 type ACT_SITE sequence G description Charge relay system => ECO:0000305|PubMed:8613982 source Swiss-Prot : SWS_FT_FI1 45) chain B residue 58 type ACT_SITE sequence C description Charge relay system => ECO:0000305|PubMed:8613982 source Swiss-Prot : SWS_FT_FI1 46) chain B residue 103 type ACT_SITE sequence I description Charge relay system => ECO:0000305|PubMed:8613982 source Swiss-Prot : SWS_FT_FI1 47) chain B residue 196 type ACT_SITE sequence G description Charge relay system => ECO:0000305|PubMed:8613982 source Swiss-Prot : SWS_FT_FI1 48) chain A residue 157 type SITE sequence E description Important for single-chain activity source Swiss-Prot : SWS_FT_FI2 49) chain A residue 195 type SITE sequence S description Important for single-chain activity source Swiss-Prot : SWS_FT_FI2 50) chain B residue 157 type SITE sequence E description Important for single-chain activity source Swiss-Prot : SWS_FT_FI2 51) chain B residue 195 type SITE sequence S description Important for single-chain activity source Swiss-Prot : SWS_FT_FI2 52) chain A residue 174 type CARBOHYD sequence R description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2513186 source Swiss-Prot : SWS_FT_FI3 53) chain B residue 174 type CARBOHYD sequence R description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2513186 source Swiss-Prot : SWS_FT_FI3 54) chain A residue 53-58 type prosite sequence LSAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC source prosite : PS00134 55) chain A residue 189-200 type prosite sequence DACQGDSGGPLV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAcqGDSGGPLV source prosite : PS00135

Display surface Download Links