eF-site ID 1b8o-A
PDB Code 1b8o
Chain A

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Title PURINE NUCLEOSIDE PHOSPHORYLASE
Classification TRANSFERASE
Compound PURINE NUCLEOSIDE PHOSPHORYLASE
Source ORGANISM_COMMON: cattle; ORGANISM_SCIENTIFIC: Bos taurus;
Sequence A:  NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKL
TQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQ
GRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNP
NFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAM
SDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFET
VAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLIT
NKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASI
Description


Functional site
1) chain A
residue 32
type
sequence G
description BINDING SITE FOR RESIDUE PO4 A 599
source : AC2
2) chain A
residue 33
type
sequence S
description BINDING SITE FOR RESIDUE PO4 A 599
source : AC2
3) chain A
residue 64
type
sequence H
description BINDING SITE FOR RESIDUE PO4 A 599
source : AC2
4) chain A
residue 84
type
sequence R
description BINDING SITE FOR RESIDUE PO4 A 599
source : AC2
5) chain A
residue 86
type
sequence H
description BINDING SITE FOR RESIDUE PO4 A 599
source : AC2
6) chain A
residue 115
type
sequence N
description BINDING SITE FOR RESIDUE PO4 A 599
source : AC2
7) chain A
residue 116
type
sequence A
description BINDING SITE FOR RESIDUE PO4 A 599
source : AC2
8) chain A
residue 220
type
sequence S
description BINDING SITE FOR RESIDUE PO4 A 599
source : AC2
9) chain A
residue 86
type
sequence H
description BINDING SITE FOR RESIDUE IMH A 600
source : AC3
10) chain A
residue 88
type
sequence Y
description BINDING SITE FOR RESIDUE IMH A 600
source : AC3
11) chain A
residue 116
type
sequence A
description BINDING SITE FOR RESIDUE IMH A 600
source : AC3
12) chain A
residue 117
type
sequence A
description BINDING SITE FOR RESIDUE IMH A 600
source : AC3
13) chain A
residue 118
type
sequence G
description BINDING SITE FOR RESIDUE IMH A 600
source : AC3
14) chain A
residue 200
type
sequence F
description BINDING SITE FOR RESIDUE IMH A 600
source : AC3
15) chain A
residue 201
type
sequence E
description BINDING SITE FOR RESIDUE IMH A 600
source : AC3
16) chain A
residue 218
type
sequence G
description BINDING SITE FOR RESIDUE IMH A 600
source : AC3
17) chain A
residue 219
type
sequence M
description BINDING SITE FOR RESIDUE IMH A 600
source : AC3
18) chain A
residue 242
type
sequence T
description BINDING SITE FOR RESIDUE IMH A 600
source : AC3
19) chain A
residue 243
type
sequence N
description BINDING SITE FOR RESIDUE IMH A 600
source : AC3
20) chain A
residue 245
type
sequence V
description BINDING SITE FOR RESIDUE IMH A 600
source : AC3
21) chain A
residue 257
type
sequence H
description BINDING SITE FOR RESIDUE IMH A 600
source : AC3
22) chain A
residue 260
type
sequence V
description BINDING SITE FOR RESIDUE IMH A 600
source : AC3
23) chain A
residue 79-120
type prosite
sequence VMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAG
GL
description PNP_MTAP_2 Purine and other phosphorylases family 2 signature. VmmqGrfHmYegypFwkvTfpVrVfrllGvet.LVvtNAaGGL
source prosite : PS01240
24) chain A
residue 33
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9O, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP
source Swiss-Prot : SWS_FT_FI1
25) chain A
residue 64
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP
source Swiss-Prot : SWS_FT_FI2
26) chain A
residue 84
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9O, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9Q, ECO:0007744|PDB:1A9R, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP
source Swiss-Prot : SWS_FT_FI3
27) chain A
residue 116
type BINDING
sequence A
description BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9O, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9Q, ECO:0007744|PDB:1A9R, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP
source Swiss-Prot : SWS_FT_FI3
28) chain A
residue 220
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9O, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9Q, ECO:0007744|PDB:1A9R, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP
source Swiss-Prot : SWS_FT_FI3
29) chain A
residue 88
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T
source Swiss-Prot : SWS_FT_FI4
30) chain A
residue 219
type BINDING
sequence M
description BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T
source Swiss-Prot : SWS_FT_FI4
31) chain A
residue 257
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T
source Swiss-Prot : SWS_FT_FI4
32) chain A
residue 201
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:9585525, ECO:0000305|PubMed:9020983, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9Q, ECO:0007744|PDB:1A9R, ECO:0007744|PDB:1VFN
source Swiss-Prot : SWS_FT_FI5
33) chain A
residue 243
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:9585525, ECO:0000305|PubMed:9020983, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9Q, ECO:0007744|PDB:1A9R, ECO:0007744|PDB:1VFN
source Swiss-Prot : SWS_FT_FI5
34) chain A
residue 243
type SITE
sequence N
description Important for substrate specificity => ECO:0000250|UniProtKB:P00491
source Swiss-Prot : SWS_FT_FI6
35) chain A
residue 251
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P00491
source Swiss-Prot : SWS_FT_FI8

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